Medicine Information

Mebendox

Name: Mebendox
Brand: Mebendox
Rating: 4.5 (117 reviews)

Suspension100 mg/5 mLAnthelminticATC: P02CA01

Generic Name

Mebendazole

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
mebendox 100 mg suspension	৳ 14.00	N/A

Description

Overview of the medicine

Mebendox is an anthelmintic agent used to treat various parasitic worm infections such as pinworm, roundworm, whipworm, and hookworm.

Uses & Indications

Enterobiasis (Pinworm)

Ascariasis (Roundworm)

Trichuriasis (Whipworm)

Hookworm infections (Ancylostomiasis, Necatoriasis)

Capillariasis, Trichinellosis, Echinococcosis (off-label or specific regimens)

Dosage

Adults

Pinworm: 100 mg as a single dose, repeated in 2-4 weeks. Other infections (roundworm, whipworm, hookworm): 100 mg twice daily for 3 consecutive days.

Elderly

No specific dose adjustment is generally required for elderly patients.

Renal_impairment

No specific dose adjustment is needed for patients with renal impairment, as absorption is minimal and excretion is primarily fecal.

How to Take

Take orally with or without food. The suspension can be swallowed directly. For pinworm, it is advisable to treat all household members simultaneously.

Mechanism of Action

Mebendazole selectively and irreversibly blocks glucose uptake and other nutrients in susceptible intestinal nematodes. This leads to the depletion of glycogen stores, reduced ATP formation, and ultimately the death of the parasite.

Pharmacokinetics

Onset

Therapeutic effects usually seen within a few days of starting treatment.

Excretion

Primarily excreted via feces (unabsorbed drug) and urine (metabolites).

Half life

Approximately 2.5 to 5.5 hours in plasma.

Absorption

Poorly absorbed systemically from the gastrointestinal tract (about 5-10%). Absorption is increased when taken with a fatty meal.

Metabolism

Rapidly and extensively metabolized in the liver, primarily by CYP450 enzymes, to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to mebendazole or any components of the formulation.
Pregnancy (especially first trimester, unless clearly needed and benefits outweigh risks).
Children under 2 years of age for mass treatment (though commonly used for therapeutic reasons under medical supervision).

Drug Interactions

Cimetidine

May inhibit the metabolism of mebendazole, leading to increased plasma concentrations.

Metronidazole

Concurrent use has been associated with an increased risk of Stevens-Johnson syndrome/toxic epidermal necrolysis (rare cases).

Phenytoin, Carbamazepine

May decrease mebendazole plasma levels due to enzyme induction.

Storage

Store below 30°C. Protect from light and moisture. Keep out of reach of children. Do not freeze.

Overdose

In case of overdose, symptoms may include abdominal cramps, nausea, vomiting, and diarrhea. Treatment is symptomatic and supportive, including gastric lavage if ingested recently.

Pregnancy & Lactation

Pregnancy Category C. Consult a doctor before use. Small amounts are excreted into breast milk, generally considered compatible with breastfeeding at usual doses, but physician consultation is advised.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 mL bottle (100 mg/5 mL)30 mL bottle (100 mg/5 mL)

Shelf Life

2-3 years from manufacturing date, check specific packaging for details.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic

WHO Essential Medicine

Yes

Clinical Trials

Mebendazole has undergone extensive clinical trials demonstrating its efficacy and safety for treating various intestinal helminthic infections across different age groups.

Lab Monitoring

Liver function tests (for prolonged high-dose therapy)
Complete blood counts (for prolonged high-dose therapy)

Doctor Notes

Emphasize the importance of completing the full course of treatment.
Advise patients on proper hygiene practices to prevent re-infection.
Consider treating all household members for pinworm infections to prevent recurrence.

Patient Guidelines

Complete the full course of medication even if symptoms improve.
Practice good personal hygiene, especially handwashing, to prevent re-infection.
For pinworm infections, treat all household members and practice strict hygiene measures.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.