Medicine Information

Moxibest

Name: Moxibest
Brand: Moxibest
Rating: 4.5 (117 reviews)

Tablet400 mgAntibioticATC: J01MA14

Generic Name

Moxifloxacin

Manufacturer

Acme Laboratories Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
moxibest 400 mg tablet	৳ 45.00	৳ 450.00

Description

Overview of the medicine

Moxibest 400 mg Tablet contains Moxifloxacin, a broad-spectrum fluoroquinolone antibiotic used to treat a variety of bacterial infections.

Uses & Indications

Acute bacterial sinusitis

Acute exacerbation of chronic bronchitis

Community-acquired pneumonia

Uncomplicated skin and skin structure infections

Complicated skin and skin structure infections

Complicated intra-abdominal infections

Dosage

Adults

400 mg once daily for 5-14 days, depending on the infection.

Elderly

No dosage adjustment is generally required for elderly patients.

Renal_impairment

No dosage adjustment is required for patients with mild to severe renal impairment (creatinine clearance ≤30 mL/min) or end-stage renal disease on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD).

How to Take

Moxibest 400 mg tablet should be swallowed whole with a glass of water, with or without food. Do not chew or crush the tablet.

Mechanism of Action

Moxifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.

Pharmacokinetics

Onset

Within hours of administration, therapeutic concentrations reached at infection sites.

Excretion

Approximately 45% of the dose is excreted in urine (20% as unchanged drug, 25% as metabolites) and 50% in feces (20% as unchanged drug, 30% as metabolites).

Half life

Approximately 11-15 hours.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract; absolute bioavailability is approximately 90%. Peak plasma concentrations are achieved within 0.5-4 hours.

Metabolism

Undergoes hepatic metabolism mainly via glucuronide and sulfate conjugation, without significant involvement of cytochrome P450 system.

Side Effects

Contraindications

Hypersensitivity to moxifloxacin or other quinolones.
History of tendinitis or tendon rupture associated with quinolone use.
Patients with known prolongation of the QT interval, uncorrected hypokalemia, or significant bradycardia.
Co-administration with other drugs that prolong the QT interval.
Severe hepatic impairment.

Drug Interactions

Warfarin

Enhanced anticoagulant effect. INR monitoring is recommended.

Corticosteroids

Increased risk of tendinitis and tendon rupture.

Antacids containing aluminum, magnesium, iron, sucralfate, zinc

May reduce the absorption of moxifloxacin. Administer moxifloxacin several hours before or after these agents.

Drugs that prolong the QT interval (e.g., Class IA and III antiarrhythmics, tricyclic antidepressants, macrolides, antipsychotics)

Increased risk of ventricular arrhythmias, including Torsades de Pointes. Co-administration is contraindicated.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

In the event of an acute overdose, patients should be carefully observed and given supportive treatment. Gastric lavage and activated charcoal may be considered shortly after ingestion. ECG monitoring is recommended due to the potential for QT interval prolongation. Hemodialysis or peritoneal dialysis is not expected to be beneficial.

Pregnancy & Lactation

Pregnancy Category C. Moxifloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted into breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 tablets (blister pack)10 tablets (blister pack)

Shelf Life

Typically 24-36 months from the date of manufacture, specific to manufacturer.

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by FDA/DGDA

Patent Status

Off-patent (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Moxifloxacin has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections. Post-marketing surveillance continues to monitor its long-term effects and safety profile.

Lab Monitoring

Monitor renal function, especially in patients with pre-existing kidney disease, although dose adjustment is not typically required.
Monitor liver function tests periodically in patients with hepatic impairment or those developing signs/symptoms of liver injury.
Monitor ECG for QT interval prolongation in patients at risk.

Doctor Notes

Counsel patients on the black box warnings, especially regarding tendon issues and neurological adverse events.
Carefully assess patient history for QT prolongation risk factors before prescribing.
Avoid co-administration with other QT-prolonging drugs.
Consider alternative antibiotics for uncomplicated infections when possible.

Patient Guidelines

Complete the full course of medication even if symptoms improve.
Do not share your medication with others.
Inform your doctor if you experience any unusual pain or swelling in tendons.
Avoid excessive exposure to direct sunlight or artificial UV light.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Moxibest may cause dizziness, lightheadedness, or visual disturbances. Patients should be cautioned against operating hazardous machinery or driving until they are reasonably certain that moxifloxacin does not affect them adversely.

Lifestyle Advice

Stay well-hydrated by drinking plenty of fluids.
Avoid driving or operating machinery if you experience dizziness or visual disturbances.
Report any new or worsening muscle weakness, numbness, tingling, or pain to your doctor immediately.