Medicine Information

Olanap

Name: Olanap
Brand: Olanap
Rating: 4.5 (117 reviews)

Tablet5 mgAntipsychoticATC: N05AH03

Generic Name

Olanzapine

Manufacturer

Incepta Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
olanap 5 mg tablet	৳ 2.50	৳ 25.00

Description

Overview of the medicine

Olanap 5 mg Tablet contains Olanzapine, an atypical antipsychotic medicine used to treat conditions such as schizophrenia and bipolar disorder. It helps to restore the balance of certain natural substances in the brain, improving mood, thoughts, and behavior.

Uses & Indications

Treatment of schizophrenia

Treatment of moderate to severe manic episodes in bipolar I disorder

Prevention of recurrence in bipolar disorder patients who responded to olanzapine treatment during a manic episode

Short-term treatment of acute agitation associated with schizophrenia and bipolar mania (IM formulation)

Dosage

Adults

Schizophrenia: Initial dose is 10 mg once daily. Dosage range 5-20 mg/day. Bipolar Mania: Initial dose is 10-15 mg once daily as monotherapy, or 10 mg once daily as adjunctive therapy. Dosage range 5-20 mg/day.

Elderly

A lower initial dose (e.g., 5 mg/day) may be considered, especially for those with factors that might result in slower metabolism (e.g., non-smoking female patients ≥65 years of age). Close monitoring is recommended.

Renal_impairment

No routine dosage adjustment is required in patients with renal impairment, but caution is advised, particularly in severe cases. Close monitoring of clinical response is recommended.

How to Take

Olanap 5 mg Tablet should be taken orally, once daily, with or without food. It is generally recommended to take it at the same time each day, preferably in the evening, as it can cause drowsiness.

Mechanism of Action

Olanzapine acts as an antagonist at multiple receptor sites, including dopamine D2 and D1, D3, D4 receptors, and serotonin 5-HT2A, 5-HT2C, 5-HT3, 5-HT6 receptors. It also has antagonistic activity at muscarinic M1-M5, histamine H1, and alpha-1 adrenergic receptors. Its antipsychotic effect is primarily attributed to its combined antagonism of dopamine D2 and serotonin 5-HT2A receptors.

Pharmacokinetics

Onset

Antipsychotic effects may begin within a few days, but full therapeutic effect may take several weeks. Sedative effects can occur shortly after administration.

Excretion

Approximately 57% of the dose is excreted in the urine and about 30% in feces, mainly as metabolites.

Half life

The elimination half-life ranges from 21 to 54 hours (mean 33 hours).

Absorption

Well absorbed orally; peak plasma concentrations reached in approximately 5-8 hours. Bioavailability is not affected by food.

Metabolism

Extensively metabolized in the liver, primarily via direct glucuronidation and cytochrome P450-mediated oxidation (CYP1A2 and CYP2D6).

Side Effects

Contraindications

Known hypersensitivity to olanzapine or any component of the formulation
Patients at high risk of developing narrow-angle glaucoma
Patients with a history of paralytic ileus

Drug Interactions

Antihypertensives

May increase the risk of orthostatic hypotension with olanzapine.

Anticholinergic drugs

May enhance anticholinergic effects like dry mouth, constipation, and blurred vision.

CNS Depressants (e.g., alcohol, benzodiazepines)

May enhance the sedative and hypotensive effects of olanzapine.

CYP1A2 Inhibitors (e.g., fluvoxamine, ciprofloxacin)

May increase olanzapine plasma levels, requiring dose reduction.

CYP1A2 Inducers (e.g., carbamazepine, rifampin, omeprazole)

May decrease olanzapine plasma levels, potentially reducing efficacy.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose typically include drowsiness, tachycardia, extrapyramidal symptoms, blurred vision, respiratory depression, and hypotension. There is no specific antidote. Treatment is supportive and symptomatic, including maintaining an adequate airway, oxygenation, and ventilation, and monitoring cardiovascular function.

Pregnancy & Lactation

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Olanzapine is excreted in human milk; therefore, women should not breastfeed while taking this medication.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister30 tablets per box

Shelf Life

3 years

Availability

Available in pharmacies and hospitals

Approval Status

Approved

Patent Status

Patent expired (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Olanzapine has undergone extensive clinical trials demonstrating its efficacy and safety in the treatment of schizophrenia and bipolar disorder. Studies have shown significant improvements in positive and negative symptoms of schizophrenia and reduction in manic and depressive symptoms in bipolar disorder, compared to placebo and other antipsychotics. Post-marketing surveillance continues to monitor long-term safety.

Lab Monitoring

Fasting plasma glucose (baseline, 4 months after initiation, then annually)
Lipid panel (baseline, 4 months after initiation, then annually)
Weight and BMI (baseline, monthly for first few months, then quarterly)
Liver function tests (periodically, especially in patients with hepatic impairment)
Complete Blood Count (CBC) with differential (periodically)

Doctor Notes

Prioritize thorough psychiatric evaluation and patient history before initiating olanzapine.
Regularly monitor for metabolic side effects (weight, glucose, lipids) and educate patients on lifestyle modifications.
Be vigilant for extrapyramidal symptoms, NMS, and tardive dyskinesia. Adjust dose or consider alternative if these occur.
Counsel patients and caregivers on the importance of adherence and potential for withdrawal symptoms if stopped abruptly.
Consider lower starting doses in elderly or debilitated patients, or those with hepatic/renal impairment.

Patient Guidelines

Take this medication exactly as prescribed by your doctor. Do not stop taking it without consulting your doctor, even if you feel better, as symptoms may return.
Be aware of potential side effects like drowsiness, weight gain, and dizziness. Avoid driving or operating machinery until you know how this medicine affects you.
Regularly monitor your weight, blood sugar, and lipid levels as advised by your doctor.
Report any unusual symptoms such as uncontrolled muscle movements, fever, severe stiffness, or confusion to your doctor immediately.

Missed Dose Advice

If you miss a dose of Olanap 5 mg Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

Driving Precautions

Olanap 5 mg Tablet may cause drowsiness, dizziness, and blurred vision, which can impair your ability to drive or operate machinery safely. Patients should be warned not to drive or operate hazardous machinery until they are reasonably certain that olanzapine therapy does not adversely affect their ability to perform such activities.

Lifestyle Advice

Maintain a healthy diet and regular exercise routine to manage potential weight gain associated with olanzapine.
Avoid alcohol consumption as it can increase drowsiness and other side effects.
If you smoke, discuss smoking cessation with your doctor as smoking can affect olanzapine levels and efficacy.