Medicine Information

Plator-Plus

Name: Plator-Plus
Brand: Plator-Plus
Rating: 4.5 (117 reviews)

TabletClopidogrel 75 mg + Aspirin 75 mgAntiplateletATC: B01AC30

Generic Name

Clopidogrel + Aspirin

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
plator plus 75 mg tablet	৳ 14.40	৳ 144.00

Description

Overview of the medicine

Plator-Plus is a combination medicine containing Clopidogrel and Aspirin, used to prevent blood clots in conditions like acute coronary syndrome, heart attack, and stroke.

Uses & Indications

Prevention of atherothrombotic events in adult patients with acute coronary syndrome (unstable angina, NSTEMI, or STEMI).

Prevention of atherothrombotic and thromboembolic events in patients with prior myocardial infarction, ischemic stroke, or established peripheral arterial disease.

Dosage

Adults

Usually one tablet (Clopidogrel 75 mg + Aspirin 75 mg) once daily.

Elderly

No specific dose adjustment is required for elderly patients.

Renal_impairment

Use with caution in patients with severe renal impairment; dose adjustment may be necessary based on clinical judgment.

How to Take

Oral administration, with or without food. Swallow the tablet whole with water.

Mechanism of Action

Clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor, preventing platelet activation and aggregation. Aspirin irreversibly inhibits cyclooxygenase (COX-1) in platelets, which reduces thromboxane A2 (TXA2) production, further inhibiting platelet aggregation.

Pharmacokinetics

Onset

Within 2-3 hours for antiplatelet effect.

Excretion

Mainly renal excretion for metabolites; some fecal excretion for clopidogrel.

Half life

Clopidogrel: ~6 hours (active metabolite); Aspirin: 15-20 minutes (plasma), antiplatelet effect lasts for the lifetime of platelets (7-10 days).

Absorption

Clopidogrel is rapidly absorbed and extensively metabolized. Aspirin is rapidly and completely absorbed.

Metabolism

Both are extensively metabolized in the liver.

Side Effects

Contraindications

Active pathological bleeding (e.g., peptic ulcer, intracranial hemorrhage).
Severe hepatic impairment.
Known hypersensitivity to clopidogrel, aspirin, or any component of the product.

Drug Interactions

SSRIs

Increased risk of bleeding.

NSAIDs

Increased risk of gastrointestinal bleeding.

Proton Pump Inhibitors (PPIs)

May reduce the antiplatelet effect of clopidogrel (e.g., omeprazole, esomeprazole).

Anticoagulants (e.g., Warfarin)

Increased risk of bleeding.

Storage

Store below 25°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Overdose may lead to increased bleeding risk, epigastric pain, nausea, vomiting, dizziness, tinnitus, and hearing impairment. Management is symptomatic and supportive, with close monitoring for bleeding complications.

Pregnancy & Lactation

Not recommended during pregnancy, especially in the third trimester, due to potential fetal harm (e.g., premature closure of ductus arteriosus). Avoid during lactation as both drugs are excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per box30 tablets per box

Shelf Life

2-3 years from the date of manufacture.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by DGDA

Patent Status

Off-patent (generic available)

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials support the efficacy and safety of both clopidogrel and aspirin in preventing cardiovascular events, especially in combination therapy.

Lab Monitoring

Complete blood count (CBC) including hemoglobin and platelet count.
Liver and renal function tests, especially in patients with pre-existing impairment or during long-term therapy.

Doctor Notes

Emphasize the importance of patient compliance and adherence to the prescribed dosage.
Advise patients to inform all healthcare providers, including dentists, about their use of Plator-Plus before any procedures, due to the increased bleeding risk.

Patient Guidelines

Take this medicine regularly as prescribed by your doctor.
Report any signs of unusual bleeding or bruising immediately to your doctor.
Do not stop taking this medicine without consulting your doctor, even if you feel well.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.

Driving Precautions

Plator-Plus is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or any other side effects that could impair your judgment, avoid such activities.