Povisep
Generic Name
Povidone-iodine
Manufacturer
Acme Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| povisep 5 w powder | ৳ 30.10 | N/A |
Description
Overview of the medicine
Povisep 5% w/w powder is a topical antiseptic containing povidone-iodine, used for preventing and treating skin infections in minor cuts, wounds, burns, and abrasions. It helps to keep the wound clean and promotes healing.
Uses & Indications
Dosage
Adults
Clean the affected area thoroughly. Apply a thin layer of Povisep 5% w/w powder once or twice daily, or as directed by a physician. Cover with a sterile dressing if necessary.
Elderly
No specific dosage adjustment required. Use with caution in elderly patients with pre-existing thyroid conditions.
Renal_impairment
Use with caution in patients with severe renal impairment, especially with extensive application, due to potential for systemic iodine absorption.
How to Take
For external use only. Clean and dry the affected area before applying the powder. Sprinkle a thin layer directly onto the wound or skin infection. Do not ingest. Avoid contact with eyes, ears, and mucous membranes. Wash hands before and after use.
Mechanism of Action
Povidone-iodine works by slowly releasing iodine, which penetrates microbial cell walls and causes oxidative damage to their proteins, nucleotides, and fatty acids. This results in rapid killing of bacteria, viruses, fungi, and protozoa.
Pharmacokinetics
Onset
Rapid onset of action, typically within 30 seconds to a few minutes.
Excretion
Mainly excreted via the kidneys. Some excretion also occurs through feces and sweat.
Half life
Not directly applicable for topical use in terms of systemic half-life for therapeutic effect. Systemically absorbed iodine is eliminated renally with a variable half-life.
Absorption
Minimal systemic absorption when applied topically to intact skin. Absorption may increase through broken skin, mucous membranes, or extensive burns. Absorbed iodine is rapidly distributed in the body.
Metabolism
Absorbed iodine is primarily metabolized in the liver and thyroid gland.
Side Effects
Contraindications
- Known hypersensitivity to iodine or povidone
- Thyroid disorders (e.g., hyperthyroidism, goiter)
- Prior to and after radioiodine therapy
- Newborns and premature infants (due to risk of systemic iodine absorption and thyroid suppression)
- Extensive, deep, or chronic wounds without medical supervision
- Concurrent use with mercury-containing products
Drug Interactions
Lithium
Concurrent use may lead to additive hypothyroid effects, especially in patients with pre-existing thyroid conditions.
Octenidine
Avoid concurrent use as it may lead to transient skin discoloration.
Hydrogen Peroxide
May inactivate povidone-iodine, reducing its antiseptic effect.
Silver Sulfadiazine
May reduce the efficacy of both agents when used concurrently on wounds.
Storage
Store in a cool, dry place below 30°C. Protect from direct sunlight and moisture. Keep the container tightly closed.
Overdose
Accidental ingestion or excessive absorption from large or broken skin areas may lead to systemic iodine toxicity symptoms such as nausea, vomiting, diarrhea, abdominal pain, metabolic acidosis, renal impairment, and thyroid dysfunction (hyper- or hypothyroidism). Management is symptomatic and supportive, including gastric lavage if ingested and monitoring thyroid and renal function.
Pregnancy & Lactation
Use with caution during pregnancy and lactation. Avoid prolonged or extensive application, especially on broken skin, due to potential for systemic iodine absorption and adverse effects on fetal/infant thyroid function. Consult a physician before use.
Side Effects
Contraindications
- Known hypersensitivity to iodine or povidone
- Thyroid disorders (e.g., hyperthyroidism, goiter)
- Prior to and after radioiodine therapy
- Newborns and premature infants (due to risk of systemic iodine absorption and thyroid suppression)
- Extensive, deep, or chronic wounds without medical supervision
- Concurrent use with mercury-containing products
Drug Interactions
Lithium
Concurrent use may lead to additive hypothyroid effects, especially in patients with pre-existing thyroid conditions.
Octenidine
Avoid concurrent use as it may lead to transient skin discoloration.
Hydrogen Peroxide
May inactivate povidone-iodine, reducing its antiseptic effect.
Silver Sulfadiazine
May reduce the efficacy of both agents when used concurrently on wounds.
Storage
Store in a cool, dry place below 30°C. Protect from direct sunlight and moisture. Keep the container tightly closed.
Overdose
Accidental ingestion or excessive absorption from large or broken skin areas may lead to systemic iodine toxicity symptoms such as nausea, vomiting, diarrhea, abdominal pain, metabolic acidosis, renal impairment, and thyroid dysfunction (hyper- or hypothyroidism). Management is symptomatic and supportive, including gastric lavage if ingested and monitoring thyroid and renal function.
Pregnancy & Lactation
Use with caution during pregnancy and lactation. Avoid prolonged or extensive application, especially on broken skin, due to potential for systemic iodine absorption and adverse effects on fetal/infant thyroid function. Consult a physician before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, when stored properly.
Availability
Pharmacies, Hospitals, Clinics
Approval Status
Approved (OTC for topical use)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Povidone-iodine has been extensively studied and widely used for decades in various clinical settings, demonstrating its efficacy and safety as a broad-spectrum antiseptic.
Lab Monitoring
- Thyroid function tests (TFTs) may be considered for patients undergoing extensive or prolonged application of povidone-iodine, especially in those with pre-existing thyroid conditions or renal impairment.
Doctor Notes
- Emphasize proper wound cleaning prior to application.
- Advise patients on signs of infection to look out for.
- Caution against use in patients with known thyroid disease or iodine allergy.
- Remind patients that this product is for external use only.
Patient Guidelines
- For external use only. Do not swallow.
- Avoid contact with eyes. If contact occurs, rinse thoroughly with water.
- Do not use on deep puncture wounds, animal bites, or serious burns without consulting a doctor.
- Discontinue use if irritation or rash develops and consult a physician.
- Keep out of reach of children.
Missed Dose Advice
Since Povisep powder is used on an as-needed basis for topical applications, a 'missed dose' concept doesn't apply. Simply apply when required for wound care or skin disinfection.
Driving Precautions
Povisep 5% w/w powder is for topical use and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good wound hygiene.
- Ensure hands are clean before and after touching wounds.
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