Povisep
Generic Name
Povidone-iodine 5% W/V Solution
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| povisep 5 w solution | ৳ 25.07 | N/A |
Description
Overview of the medicine
Povidone-iodine 5% W/V Solution is a broad-spectrum antiseptic used for disinfecting skin, wounds, and mucous membranes. It helps to prevent and treat infections by killing bacteria, fungi, viruses, and protozoa.
Uses & Indications
Dosage
Adults
Apply undiluted solution to the affected area as needed, typically 1-3 times daily. Allow to dry. May cover with a sterile dressing.
Elderly
No specific dosage adjustments required; use as per adult dosage.
Renal_impairment
Use with caution in patients with renal impairment, especially if applied to large areas or for prolonged periods, due to potential iodine absorption.
How to Take
For external use only. Clean the affected area thoroughly. Apply a small amount of Povisep-5-W-Solution directly to the skin or wound using a sterile swab or gauze. Allow it to dry naturally.
Mechanism of Action
Povidone-iodine works by slowly releasing iodine, which is a potent oxidizing agent. The iodine penetrates microbial cell walls and oxidizes proteins, nucleotides, and fatty acids, leading to cell death. It exhibits a broad spectrum of antimicrobial activity.
Pharmacokinetics
Onset
Rapid (within seconds to minutes)
Excretion
Absorbed iodine is primarily excreted by the kidneys.
Half life
Not well-defined for topical application; systemic iodine half-life is variable (days to weeks) if absorbed.
Absorption
Minimal systemic absorption through intact skin. Higher absorption can occur through damaged skin or mucous membranes.
Metabolism
Absorbed iodine is metabolized in the liver, similar to dietary iodine.
Side Effects
Contraindications
- Known hypersensitivity to iodine or povidone
- Thyroid disorders (e.g., hyperthyroidism, goitre)
- Neonate or premature infants (due to risk of systemic iodine absorption)
- Before and after radio-iodine scintigraphy or treatment for thyroid carcinoma
Drug Interactions
Lithium
May increase the risk of hypothyroidism due to additive effects on the thyroid.
Silver sulfadiazine
May inactivate povidone-iodine.
Mercury-containing antiseptics
Concurrent use may lead to skin damage or the formation of corrosive compounds.
Enzyme preparations for wound cleansing
Povidone-iodine can inactivate enzymes.
Storage
Store below 30°C in a dry place, away from direct sunlight and heat. Do not freeze. Keep out of reach of children.
Overdose
Systemic toxicity (e.g., metabolic acidosis, hypernatremia, renal impairment, thyroid dysfunction) can occur with extensive application to large body surfaces, prolonged use, or ingestion. Treatment is supportive, focusing on symptom management and electrolyte balance.
Pregnancy & Lactation
Use with caution and only if clearly needed. High or prolonged exposure may lead to transient hypothyroidism in the fetus/neonate. Consult a doctor before use.
Side Effects
Contraindications
- Known hypersensitivity to iodine or povidone
- Thyroid disorders (e.g., hyperthyroidism, goitre)
- Neonate or premature infants (due to risk of systemic iodine absorption)
- Before and after radio-iodine scintigraphy or treatment for thyroid carcinoma
Drug Interactions
Lithium
May increase the risk of hypothyroidism due to additive effects on the thyroid.
Silver sulfadiazine
May inactivate povidone-iodine.
Mercury-containing antiseptics
Concurrent use may lead to skin damage or the formation of corrosive compounds.
Enzyme preparations for wound cleansing
Povidone-iodine can inactivate enzymes.
Storage
Store below 30°C in a dry place, away from direct sunlight and heat. Do not freeze. Keep out of reach of children.
Overdose
Systemic toxicity (e.g., metabolic acidosis, hypernatremia, renal impairment, thyroid dysfunction) can occur with extensive application to large body surfaces, prolonged use, or ingestion. Treatment is supportive, focusing on symptom management and electrolyte balance.
Pregnancy & Lactation
Use with caution and only if clearly needed. High or prolonged exposure may lead to transient hypothyroidism in the fetus/neonate. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, check product label for exact expiry.
Availability
Pharmacies, Hospitals
Approval Status
Approved (Generally available as OTC)
Patent Status
Generic
WHO Essential Medicine
YesClinical Trials
Povidone-iodine has been extensively studied and is a well-established antiseptic with numerous clinical trials supporting its efficacy in wound care and surgical antisepsis.
Lab Monitoring
- Thyroid function tests (TFTs) may be considered for prolonged or extensive use, especially in neonates, pregnant women, or patients with pre-existing thyroid conditions.
Doctor Notes
- Ensure patient is not allergic to iodine before recommending.
- Advise against prolonged or extensive use in pregnant/lactating women and neonates.
- Monitor for signs of skin irritation or systemic effects if used on large areas.
Patient Guidelines
- For external use only. Do not swallow.
- Avoid contact with eyes. If contact occurs, rinse thoroughly with water.
- Do not use on large areas of broken skin or deep puncture wounds without medical advice.
- Discontinue use if irritation or rash develops.
Missed Dose Advice
Since this is an antiseptic for external application and not a systemic medication, there is no 'missed dose'. Apply as needed for disinfection or wound care.
Driving Precautions
Not applicable; Povisep-5-W-Solution for topical use does not affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good hygiene to prevent infections.
- For minor cuts and scrapes, clean the wound thoroughly before applying antiseptic.
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