Medicine Information

Rema-Zith

Name: Rema-Zith
Brand: Rema-Zith
Rating: 4.5 (117 reviews)

Tablet500 mgMacrolide AntibioticATC: J01FA10

Generic Name

Azithromycin 500 mg tablet

Manufacturer

Generic Pharmaceutical Company

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
rema zith 500 mg tablet	৳ 35.00	N/A

Description

Overview of the medicine

Azithromycin is a macrolide antibiotic used to treat a variety of bacterial infections, including those of the respiratory tract, skin, and sexually transmitted diseases. It works by stopping the growth of bacteria.

Uses & Indications

Respiratory tract infections (e.g., bronchitis, pneumonia)

Skin and soft tissue infections

Sexually transmitted infections (e.g., chlamydia, gonorrhea)

Otitis media (ear infections)

Pharyngitis/Tonsillitis (streptococcal pharyngitis as an alternative to beta-lactam antibiotics)

Dosage

Adults

Typical dosage for most infections: 500 mg once daily for 3 days, or 500 mg on day 1 followed by 250 mg once daily for 4 days. For certain STIs, a single 1g dose.

Elderly

No specific dosage adjustment is required in elderly patients with normal renal and hepatic function.

Renal_impairment

No dosage adjustment needed for mild to moderate renal impairment. Caution advised in severe renal impairment.

How to Take

Rema-Zith 500 mg tablet should be taken orally, with or without food. Taking it with food may help reduce gastrointestinal upset.

Mechanism of Action

Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby preventing peptide translocation.

Pharmacokinetics

Onset

Onset of action varies depending on the infection type and severity, typically within hours to days.

Excretion

Mainly excreted unchanged in the feces via biliary excretion; a minor amount is excreted renally.

Half life

Terminal half-life is long, ranging from 2 to 4 days.

Absorption

Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%.

Metabolism

Primarily metabolized in the liver by N-demethylation.

Side Effects

Contraindications

Hypersensitivity to azithromycin, erythromycin, or any macrolide or ketolide antibiotic.
History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.

Drug Interactions

Digoxin

Increased serum digoxin levels.

Antacids

May reduce azithromycin absorption; take azithromycin at least 1 hour before or 2 hours after antacids.

Warfarin

Increased anticoagulant effect, monitor INR.

Nelfinavir

Increased azithromycin serum concentrations.

Cyclosporine

Potential for increased cyclosporine levels; monitor cyclosporine concentrations.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage and general supportive measures are indicated. Monitor ECG for QT prolongation.

Pregnancy & Lactation

Pregnancy Category B. Use only if clearly needed. Azithromycin is excreted in breast milk; caution should be exercised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

3 tablets per pack5 tablets per pack

Shelf Life

Typically 24-36 months from the date of manufacture.

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by regulatory bodies (e.g., FDA, DGDA)

Patent Status

Generic available (original patent expired)

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have established the efficacy and safety of azithromycin for its approved indications.

Lab Monitoring

Liver function tests (in patients with pre-existing hepatic impairment or during prolonged treatment)
Renal function tests (if renal impairment is suspected)
INR (if co-administered with warfarin)

Doctor Notes

Assess for potential drug interactions, especially with warfarin and other QT-prolonging agents.
Emphasize the importance of completing the full course of treatment to prevent antibiotic resistance.
Advise patients to seek medical attention if they experience severe gastrointestinal symptoms or signs of C. difficile colitis.

Patient Guidelines

Complete the entire course of medication, even if symptoms improve.
Do not share this medication with others.
Report any severe or persistent side effects to your doctor.
Avoid antacids for 1-2 hours around your azithromycin dose.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Azithromycin may cause dizziness or visual disturbances in some individuals. Patients should be cautious when driving or operating machinery until they know how the medication affects them.