Abecab

Take the tablet orally once daily with or without food. Swallow the tablet whole with water. Do not crush or chew.

Amlodipine inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. The contractile process of cardiac muscle and vascular smooth muscle is dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine reduces peripheral vascular resistance and blood pressure by acting directly on vascular smooth muscle to cause vasodilation.

• Known hypersensitivity to Amlodipine or other dihydropyridines.
• Severe hypotension.
• Cardiogenic shock.
• Obstruction of the outflow tract of the left ventricle (e.g., high grade aortic stenosis).
• Unstable angina (except Prinzmetal’s angina).

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Symptoms of overdose include excessive peripheral vasodilation with marked hypotension and possibly reflex tachycardia. Management involves active cardiovascular support, including frequent monitoring of blood pressure and heart rate, and elevation of extremities. If hypotension persists despite adequate fluid administration, vasopressors may be considered. Calcium gluconate may reverse the effects of calcium channel blockade.

Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether Amlodipine is excreted in human milk. Exercise caution when administering to a nursing mother.