Medicine Information

Accuzith

Name: Accuzith
Brand: Accuzith
Rating: 4.5 (117 reviews)

Suspension200 mg/5 mlMacrolide AntibioticsATC: J01FA10

Generic Name

Azithromycin 200 mg/5 ml Suspension

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
accuzith 200 mg suspension	৳ 170.00	N/A

Description

Overview of the medicine

Accuzith 200 mg suspension is an antibiotic containing Azithromycin, used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria.

Uses & Indications

Respiratory tract infections (e.g., bronchitis, pneumonia, sinusitis)

Skin and soft tissue infections

Acute otitis media (ear infection)

Sexually transmitted diseases (e.g., chlamydia, gonorrhea)

Pharyngitis/Tonsillitis

Dosage

Adults

Not typically used for adults in this specific suspension strength. For adult infections, higher strength tablets or capsules are generally prescribed. Dosage varies by indication (e.g., 500 mg once daily for 3 days or 250 mg once daily for 5 days).

Elderly

No specific dosage adjustment for elderly patients with normal renal and hepatic function. Dosage should be similar to adults where applicable, with caution for underlying conditions.

Renal_impairment

No dosage adjustment necessary for mild to moderate renal impairment (creatinine clearance >40 ml/min). Use with caution in severe renal impairment (creatinine clearance <10 ml/min).

How to Take

For oral use. Shake the bottle well before each use. Can be taken with or without food. Use the provided measuring spoon or cup for accurate dosing.

Mechanism of Action

Azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing translocation of peptide chains.

Pharmacokinetics

Onset

Clinical effects typically observed within 2-3 days.

Excretion

Mainly excreted unchanged in bile; a small portion is excreted renally.

Half life

Terminal elimination half-life is 2-4 days.

Absorption

Rapidly absorbed from the gastrointestinal tract; bioavailability is approximately 37%.

Metabolism

Primarily metabolized in the liver by N-demethylation.

Side Effects

Contraindications

Known hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or any component of the formulation.
History of cholestatic jaundice/hepatic dysfunction associated with prior azithromycin use.

Drug Interactions

Digoxin

May increase serum digoxin levels. Monitor digoxin levels.

Warfarin

May enhance the anticoagulant effect of warfarin. Monitor prothrombin time/INR.

Nelfinavir

Can increase azithromycin serum concentrations. Monitor for azithromycin side effects.

Cyclosporine

May increase cyclosporine levels. Monitor cyclosporine levels and adjust dosage if necessary.

Antacids (aluminum and magnesium-containing)

Can reduce peak plasma levels of azithromycin. Administer azithromycin at least 2 hours before or 4 hours after antacids.

Storage

Store the dry powder below 30°C, protected from light and moisture. After reconstitution, store the suspension at room temperature (not exceeding 30°C) and use within the recommended period. Do not freeze.

Overdose

Symptoms of overdose may include severe nausea, vomiting, diarrhea, and reversible hearing loss. Management involves symptomatic and supportive measures. Gastric lavage and general supportive measures are indicated as required.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Azithromycin is excreted in human milk; use with caution in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

15 ml bottle (when reconstituted)20 ml bottle (when reconstituted)35 ml bottle (when reconstituted)50 ml bottle (when reconstituted)

Shelf Life

Unreconstituted powder: 2-3 years. Reconstituted suspension: Typically 5-10 days (refer to product insert).

Availability

Available in pharmacies and hospitals

Approval Status

Approved by regulatory authorities (e.g., FDA, DGDA)

Patent Status

Generic available, patent expired

WHO Essential Medicine

Yes

Clinical Trials

Azithromycin has undergone extensive clinical trials demonstrating its efficacy and safety in various bacterial infections across different patient populations, including pediatric. Ongoing research continues to explore new applications and resistance patterns.

Lab Monitoring

Liver function tests (especially in patients with pre-existing hepatic impairment or during prolonged treatment)
Renal function tests (in patients with severe renal impairment)
INR/Prothrombin time (if co-administered with warfarin)
Digoxin levels (if co-administered with digoxin)

Doctor Notes

Emphasize the importance of completing the full course to patients.
Consider potential drug interactions, especially with anticoagulants and digoxin.
Advise parents/caregivers on proper measurement and administration for pediatric patients.
Counsel on recognizing and reporting signs of C. difficile infection or severe allergic reactions.

Patient Guidelines

Complete the full course of medication, even if symptoms improve.
Do not share your medication with others.
Shake the suspension well before each use.
Store at room temperature as instructed.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

May cause dizziness or visual disturbances in some individuals. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that azithromycin does not affect them adversely.

Lifestyle Advice

Maintain good hydration throughout the course of treatment.
Avoid consuming alcohol while on antibiotics, as it may worsen side effects or reduce effectiveness.