Medicine Information

Aces Plus

Name: Aces Plus
Brand: Aces Plus
Rating: 4.5 (117 reviews)

TabletParacetamol 500 mg + Caffeine 65 mgAnalgesic, AntipyreticATC: N02BE51

Generic Name

Paracetamol (Acetaminophen) + Caffeine

Manufacturer

ACME Laboratories Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
aces plus tablet	৳ 4.00	N/A

Description

Overview of the medicine

Aces Plus Tablet is a combination medicine used for the relief of mild to moderate pain and fever. Paracetamol provides pain relief and reduces fever, while caffeine acts as an adjuvant, enhancing the analgesic effect of paracetamol and combating drowsiness.

Uses & Indications

Relief of mild to moderate pain (e.g., headache, migraine, muscle aches, backache, dental pain, menstrual pain, rheumatic pain)

Reduction of fever

Relief of symptoms of colds and flu

Dosage

Adults

1-2 tablets every 4-6 hours as needed. Do not exceed 8 tablets (4000 mg Paracetamol) in 24 hours.

Elderly

No specific dose adjustment is usually necessary, but caution is advised in elderly patients with impaired renal or hepatic function.

Renal_impairment

Use with caution in severe renal impairment. Dose interval may need to be extended.

How to Take

Aces Plus Tablet should be taken orally with water, with or without food.

Mechanism of Action

Paracetamol is thought to act primarily in the central nervous system, inhibiting prostaglandin synthesis. Caffeine is a central nervous system stimulant, which enhances the analgesic effect of paracetamol by increasing its absorption and acting on adenosine receptors.

Pharmacokinetics

Onset

Analgesic effect usually starts within 30-60 minutes.

Excretion

Mainly excreted in urine as metabolites. A small amount of unchanged paracetamol and caffeine is also excreted.

Half life

Paracetamol: Approximately 1-4 hours. Caffeine: Approximately 3-7 hours.

Absorption

Both paracetamol and caffeine are rapidly and well absorbed from the gastrointestinal tract following oral administration.

Metabolism

Paracetamol: Primarily metabolized in the liver via glucuronidation and sulfation, with a small amount by cytochrome P450 to a toxic intermediate (NAPQI). Caffeine: Extensively metabolized in the liver by cytochrome P450 enzymes (CYP1A2).

Side Effects

Contraindications

Hypersensitivity to paracetamol, caffeine, or any component of the formulation
Severe hepatic impairment
Severe renal impairment (for high doses of paracetamol)
Severe cardiovascular disease (due to caffeine)
Anxiety disorders or conditions aggravated by caffeine

Drug Interactions

Alcohol

Increases the risk of hepatotoxicity with paracetamol.

Warfarin

May increase the anticoagulant effect of warfarin with prolonged, high-dose paracetamol use, increasing bleeding risk.

Oral Contraceptives

May decrease caffeine clearance.

CNS Stimulants (e.g., ephedrine, pseudoephedrine)

May enhance stimulant effects due to caffeine.

Certain Antibiotics (e.g., Ciprofloxacin, Erythromycin)

May inhibit caffeine metabolism, leading to increased caffeine levels and side effects.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of paracetamol overdose include nausea, vomiting, abdominal pain, and liver damage (which may be delayed for 24-48 hours). Caffeine overdose can cause nervousness, insomnia, tremors, tachycardia, and arrhythmias. Treatment involves gastric decontamination and administration of N-acetylcysteine for paracetamol toxicity.

Pregnancy & Lactation

Paracetamol is generally considered safe during pregnancy when used at recommended doses. Caffeine should be used in moderation. Consult a doctor before use during pregnancy or lactation. Both components are excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 x 10 tablets (100 tablets per box)

Shelf Life

3 years from manufacturing date.

Availability

Available in pharmacies and drug stores

Approval Status

Generally approved and widely available

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Both paracetamol and caffeine have been extensively studied individually and in combination for their efficacy and safety in various clinical trials.

Lab Monitoring

Liver function tests (in cases of suspected overdose or prolonged high-dose therapy)
Renal function tests (in patients with pre-existing renal impairment)

Doctor Notes

Emphasize the risk of hepatotoxicity with paracetamol overdose.
Advise patients to check other medications for paracetamol content.
Caution in patients with underlying cardiac conditions due to caffeine.

Patient Guidelines

Do not exceed the recommended dose.
Avoid concomitant use with other paracetamol-containing products to prevent overdose.
Limit caffeine intake from other sources (e.g., coffee, tea) while taking this medicine.
Consult a doctor if pain persists for more than 5 days or fever for more than 3 days.

Missed Dose Advice

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.

Driving Precautions

Generally, Aces Plus Tablet does not impair the ability to drive or operate machinery. However, if you experience dizziness or nervousness, avoid such activities.