Medicine Information

Adflox

Name: Adflox
Brand: Adflox
Rating: 4.5 (117 reviews)

Capsule500 mgAntibiotic (Fluoroquinolone)ATC: J01MA02

Generic Name

Ciprofloxacin

Manufacturer

Generic Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
adflox 500 mg capsule	৳ 10.50	৳ 42.00

Description

Overview of the medicine

Adflox 500 mg Capsule is an antibiotic belonging to the fluoroquinolone class. It is used to treat a variety of bacterial infections.

Uses & Indications

Urinary Tract Infections (UTIs)

Respiratory Tract Infections (e.g., exacerbations of chronic bronchitis, pneumonia)

Skin and Soft Tissue Infections

Bone and Joint Infections

Gastrointestinal Infections (e.g., traveler's diarrhea)

Anthrax (post-exposure prophylaxis)

Dosage

Adults

Typically 250-750 mg twice daily, depending on the infection type and severity. For 500mg capsule, usually 500 mg twice daily.

Elderly

No specific dose adjustment needed based on age alone, but renal function should be considered.

Renal_impairment

Dose adjustment required. For CrCl 30-60 mL/min, 250-500 mg every 12 hours. For CrCl <30 mL/min, 250-500 mg every 18-24 hours.

How to Take

Take with a glass of water, with or without food. Do not take with dairy products or calcium-fortified juices alone. Swallow the capsule whole, do not chew or crush.

Mechanism of Action

Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.

Pharmacokinetics

Onset

Within 1-2 hours

Excretion

Primarily excreted unchanged in the urine (approximately 50-70%), and a smaller portion in the feces.

Half life

Approximately 3-5 hours

Absorption

Rapidly and well absorbed from the gastrointestinal tract; bioavailability is approximately 70-80%.

Metabolism

Partially metabolized in the liver to four active metabolites.

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or other quinolones.
Concomitant administration with tizanidine.

Drug Interactions

Warfarin

Potentiation of anticoagulant effect, increased bleeding risk.

Tizanidine

Increased risk of hypotension and sedation.

Theophylline

Increased plasma concentrations of theophylline, leading to toxicity.

Dairy products/Calcium-fortified juices

Reduced absorption of ciprofloxacin. Do not take ciprofloxacin with these alone.

Antacids containing aluminum or magnesium

Reduced absorption of ciprofloxacin. Administer ciprofloxacin 2 hours before or 6 hours after antacids.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, diarrhea, headache, dizziness, confusion, and sometimes seizures. Management is primarily supportive and symptomatic, including gastric lavage or emesis. Adequate hydration should be maintained.

Pregnancy & Lactation

Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Ciprofloxacin is excreted in breast milk; therefore, it is generally not recommended during breastfeeding due to potential risk of arthropathy in the infant.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 Capsules (1x10 strip)30 Capsules (3x10 strips)

Shelf Life

24 months

Availability

Pharmacies, Hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established ciprofloxacin's efficacy and safety for various bacterial infections since its introduction. Ongoing research continues for new indications and resistance patterns.

Lab Monitoring

Renal function (especially in elderly or patients with pre-existing renal impairment)
Liver function tests (LFTs) if prolonged treatment or history of hepatic dysfunction
Complete Blood Count (CBC) during prolonged therapy

Doctor Notes

Advise patients on the importance of completing the full course.
Caution patients about potential tendon issues and neurological side effects. Instruct to discontinue and seek medical advice if such symptoms occur.
Remind patients about drug interactions with antacids, dairy, and certain medications like tizanidine or theophylline.

Patient Guidelines

Complete the full course of treatment, even if you feel better, to prevent recurrence and resistance.
Drink plenty of fluids while taking this medication.
Avoid excessive exposure to sunlight or artificial UV light, as ciprofloxacin can increase photosensitivity.
Report any unusual pain in tendons or joints immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

May cause dizziness or lightheadedness, which can impair your ability to drive or operate machinery. Exercise caution until you know how it affects you.