Medicine Information

Adora

Name: Adora
Brand: Adora
Rating: 4.5 (117 reviews)

Tablet1000 mgAnalgesics, AntipyreticsATC: N02BE01

Generic Name

Paracetamol 1000 mg

Manufacturer

Adora Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
adora 1000 mg tablet	৳ 32.00	৳ 128.00

Description

Overview of the medicine

Adora 1000 mg Tablet is a widely used medication containing Paracetamol, an analgesic and antipyretic. It is primarily used to relieve mild to moderate pain and reduce fever.

Uses & Indications

Mild to moderate pain relief (e.g., headache, muscle ache, toothache, menstrual pain, backache)

Fever reduction (e.g., common cold, flu)

Osteoarthritis pain

Dosage

Adults

1000 mg (one tablet) every 6-8 hours as needed. Maximum 4000 mg (4 tablets) in 24 hours.

Elderly

Usually same as adults, but caution for those with renal or hepatic impairment.

Renal_impairment

Dosage adjustment may be required; consult a physician. Extended dosing interval recommended for severe impairment.

How to Take

Swallow the tablet whole with water. Can be taken with or without food. Do not exceed the recommended dose.

Mechanism of Action

Paracetamol's exact mechanism is not fully understood, but it is believed to inhibit prostaglandin synthesis primarily in the central nervous system, leading to its analgesic and antipyretic effects.

Pharmacokinetics

Onset

Pain relief: 30-60 minutes; Fever reduction: 30-60 minutes.

Excretion

Mainly excreted in urine as glucuronide and sulfate conjugates; less than 5% excreted unchanged.

Half life

1-4 hours, typically 2-3 hours in adults with normal hepatic function.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract, peak plasma concentrations reached within 30-60 minutes.

Metabolism

Primarily metabolized in the liver via glucuronidation and sulfation. A small amount is metabolized by cytochrome P450 to a reactive intermediate (NAPQI), which is detoxified by glutathione.

Side Effects

Contraindications

Hypersensitivity to Paracetamol or any component of the tablet
Severe hepatic impairment or active liver disease

Drug Interactions

Alcohol

Chronic heavy alcohol use may increase the risk of liver damage when taking Paracetamol.

Warfarin

May increase the anticoagulant effect of Warfarin, increasing bleeding risk, especially with prolonged use of high doses.

Other Paracetamol-containing products

Risk of overdose if taken concurrently.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms include nausea, vomiting, abdominal pain, sweating, and liver damage. Seek immediate medical attention. Treatment involves gastric lavage, activated charcoal, and N-acetylcysteine (NAC) administration.

Pregnancy & Lactation

Generally considered safe for use during pregnancy and lactation at recommended doses, but always consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets20 tablets100 tablets

Shelf Life

Typically 3-5 years from the date of manufacture.

Availability

Pharmacies, supermarkets

Approval Status

Approved by regulatory authorities worldwide

Patent Status

Generic; patents expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials over decades have established the safety and efficacy of Paracetamol.

Lab Monitoring

Liver function tests (in cases of overdose or prolonged high-dose use)
Renal function tests (in patients with pre-existing renal impairment)

Doctor Notes

Advise patients not to exceed 4g/day for adults.
Be cautious in patients with pre-existing liver disease or heavy alcohol users.
Educate patients on identifying Paracetamol in combination products to avoid overdose.

Patient Guidelines

Do not exceed the maximum recommended daily dose.
Avoid taking other Paracetamol-containing products concurrently.
Consult a doctor if pain or fever persists for more than a few days.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double dose.