Adronic
Generic Name
Zoledronic Acid
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| adronic 4 mg injection | ৳ 6,500.00 | N/A |
Description
Overview of the medicine
Zoledronic acid is a bisphosphonate used to treat and prevent osteoporosis, Paget's disease, and to manage hypercalcemia of malignancy and bone metastases.
Uses & Indications
Dosage
Adults
For hypercalcemia of malignancy: 4 mg as a single intravenous infusion over no less than 15 minutes. For bone metastases/multiple myeloma: 4 mg intravenously every 3-4 weeks over no less than 15 minutes.
Elderly
No specific dose adjustment required based on age, but renal function should be monitored closely.
Renal_impairment
Dosage adjustment required based on creatinine clearance. Consult prescribing information for specific guidelines.
How to Take
Administered by intravenous infusion over at least 15 minutes. Ensure proper hydration before administration. Must be prepared and administered by a healthcare professional.
Mechanism of Action
Inhibits osteoclast-mediated bone resorption by binding to hydroxyapatite in bone, leading to a decrease in bone turnover and skeletal-related events.
Pharmacokinetics
Onset
Within days for hypercalcemia; longer for bone conditions (weeks to months for full effect).
Excretion
Primarily renally excreted (approximately 50% of the administered dose within 24 hours).
Half life
Biphasic elimination with a terminal half-life of 146 hours (reflecting binding to bone and slow release).
Absorption
Low oral bioavailability; administered intravenously. Rapid distribution to bone after intravenous administration.
Metabolism
Not metabolized in humans. Exists in plasma as the intact drug.
Side Effects
Contraindications
- Hypersensitivity to zoledronic acid or other bisphosphonates
- Severe renal impairment (creatinine clearance <30 mL/min for some indications)
- Pregnancy and lactation (unless benefits clearly outweigh risks)
Drug Interactions
Aminoglycosides
May increase risk of hypocalcemia due to their synergistic effect on lowering serum calcium.
Thalidomide and Dexamethasone
Increased risk of renal dysfunction has been reported in multiple myeloma patients when zoledronic acid is used with these drugs.
Nephrotoxic drugs (e.g., NSAIDs, certain antibiotics)
Increased risk of renal toxicity when used concurrently.
Storage
Store intact vials below 30°C. Do not freeze. Protect from light. Reconstituted or diluted solution should be used immediately, or stored at 2-8°C for no more than 24 hours.
Overdose
Overdose may lead to clinically significant hypocalcemia, hypophosphatemia, and hypomagnesemia. Management involves close monitoring for electrolyte disturbances. Intravenous calcium gluconate may be administered to correct hypocalcemia.
Pregnancy & Lactation
Should not be used during pregnancy due to potential fetal harm (e.g., skeletal abnormalities). Avoid breastfeeding as it is unknown if zoledronic acid is excreted in human milk and its potential effects on the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years, as indicated on the product packaging. Reconstituted or diluted solution should be used within 24 hours if stored at 2-8°C.
Availability
Hospitals, Clinics, Pharmacies
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generics available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of zoledronic acid in various indications, including hypercalcemia of malignancy, bone metastases, and Paget's disease. Ongoing research continues to explore new applications.
Lab Monitoring
- Serum creatinine before each dose and periodically during treatment
- Calcium, phosphate, and magnesium levels, especially in patients at risk of electrolyte disturbances
- Complete blood count (CBC) occasionally
Doctor Notes
- Assess renal function (creatinine clearance) before each dose and adjust dosage as per guidelines for renal impairment.
- Educate patients on symptoms of osteonecrosis of the jaw (e.g., pain, swelling, non-healing sores) and emphasize the importance of good oral hygiene and dental care.
- Ensure adequate hydration (oral or intravenous) prior to zoledronic acid infusion to reduce the risk of renal toxicity.
Patient Guidelines
- Stay well-hydrated before and after infusion to minimize the risk of renal events.
- Report any new or unusual pain, especially in the jaw, hip, groin, or thigh, to your doctor immediately.
- Maintain good oral hygiene and have regular dental check-ups, especially before starting treatment.
- Inform your doctor about any pre-existing kidney problems or other medical conditions.
Missed Dose Advice
As this is an administered medicine by a healthcare professional, medical staff will manage the schedule. If a patient believes they have missed a scheduled dose, they should contact their doctor or clinic immediately.
Driving Precautions
Dizziness, fatigue, or flu-like symptoms may occur. Patients should be cautious when driving or operating machinery until they know how the medicine affects them.
Lifestyle Advice
- Ensure adequate calcium and vitamin D intake through diet or supplements as advised by your healthcare provider.
- Engage in weight-bearing exercises as appropriate for your condition and as advised by your doctor.
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Global Brand Names
International brand names for this medicine
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