Alkixen
Generic Name
alkixen-250-mg-capsule
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
alkixen 250 mg capsule | ৳ 350.00 | N/A |
Description
Overview of the medicine
Alkixen 250 mg Capsule is a broad-spectrum fluoroquinolone antibiotic used to treat various bacterial infections.
Uses & Indications
Dosage
Adults
250 mg orally twice daily, or 500 mg once daily, depending on the infection severity and type. Duration of treatment varies.
Elderly
No specific dose adjustment typically required unless renal function is impaired.
Renal_impairment
Dosage adjustment is necessary for patients with creatinine clearance < 50 mL/min.
How to Take
Take the capsule orally with a glass of water, with or without food. Do not chew or crush the capsule.
Mechanism of Action
Alkixen inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes involved in DNA replication, transcription, repair, and recombination, leading to bactericidal action.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Primarily excreted unchanged in the urine.
Half life
3-7 hours
Absorption
Rapidly and well absorbed from the gastrointestinal tract.
Metabolism
Minimally metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Alkixen or other fluoroquinolones.
- History of tendon disorders related to fluoroquinolone administration.
- Children and adolescents below 18 years of age (due to potential for cartilage damage).
Drug Interactions
Warfarin
May enhance anticoagulant effects, increasing bleeding risk.
Corticosteroids
Increased risk of tendon rupture.
Iron supplements, zinc supplements
Reduces absorption of Alkixen.
Antacids containing magnesium or aluminum
Reduces absorption of Alkixen.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
In case of overdose, symptoms may include nausea, vomiting, abdominal pain, dizziness, confusion, and seizures. Treatment is symptomatic and supportive, including gastric lavage and observation.
Pregnancy & Lactation
Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding due to excretion into breast milk and potential for arthropathy in the infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture.
Availability
Pharmacies nationwide
Approval Status
DGDA Approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Clinical trials have demonstrated Alkixen's efficacy and safety in treating various bacterial infections, showing comparable results to established fluoroquinolones.
Lab Monitoring
- Renal function tests (e.g., creatinine clearance) in patients with kidney impairment.
- Liver function tests if prolonged treatment or liver disease suspected.
- Blood glucose levels in diabetic patients, as fluoroquinolones can affect glucose metabolism.
Doctor Notes
- Counsel patients on the black box warnings associated with fluoroquinolones, especially regarding tendon issues and peripheral neuropathy.
- Advise against concomitant use with multivalent cations.
- Monitor for signs of hypersensitivity reactions.
Patient Guidelines
- Complete the entire course of medication, even if symptoms improve, to prevent antibiotic resistance.
- Stay well-hydrated while taking this medicine.
- Avoid direct sunlight and use sunscreen as Alkixen can increase sensitivity to the sun.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Alkixen may cause dizziness, lightheadedness, or visual disturbances. Patients should assess their reaction to the drug before driving or operating machinery.
Lifestyle Advice
- Avoid alcohol consumption as it may exacerbate side effects like dizziness or drowsiness.
- Maintain good hygiene to prevent reinfection.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
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