Medicine Information

Alvita

Name: Alvita
Brand: Alvita
Rating: 4.5 (117 reviews)

Tablet100 mgVitaminsATC: A11DA01

Generic Name

Thiamine Hydrochloride

Manufacturer

Hypothetical Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
alvita 100 mg tablet	৳ 7.00	৳ 70.00

Description

Overview of the medicine

Alvita 100 mg Tablet contains Thiamine Hydrochloride (Vitamin B1), essential for carbohydrate metabolism and nerve function. It is used to prevent and treat thiamine deficiency.

Uses & Indications

Prevention and treatment of thiamine deficiency (beriberi)

Wernicke-Korsakoff syndrome

Polyneuritis associated with pregnancy or alcoholism

Dosage

Adults

For mild deficiency: 10-25 mg daily. For severe deficiency: 50-100 mg daily in divided doses. For Wernicke-Korsakoff: 100 mg orally or parenterally initially, then 50-100 mg daily until symptoms subside.

Elderly

Dosage similar to adults, no specific adjustment needed unless severe renal or hepatic impairment.

Renal_impairment

No specific dosage adjustment required, as thiamine is water-soluble and excreted.

How to Take

Oral. Can be taken with or without food. Follow your doctor's or pharmacist's instructions.

Mechanism of Action

Thiamine is converted into its active form, thiamine pyrophosphate (TPP), which is a coenzyme for several enzymes involved in carbohydrate metabolism, including pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase. It is also involved in the pentose phosphate pathway.

Pharmacokinetics

Onset

Clinical improvement in deficiency symptoms can be observed within hours to days.

Excretion

Excreted primarily in the urine, both as unmetabolized thiamine and its metabolites.

Half life

Approximately 98 minutes, with a biological half-life of 18 days for total body thiamine.

Absorption

Well absorbed orally, mainly in the duodenum and ileum, by an active transport mechanism at low concentrations and by passive diffusion at high concentrations.

Metabolism

Metabolized in the liver to thiamine pyrophosphate (TPP) and other inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to thiamine or any component of the formulation.
Not recommended for treatment of megaloblastic anemia unless combined with other appropriate vitamins (e.g., B12).

Drug Interactions

Alcohol

Chronic alcohol consumption increases thiamine requirements and can impair absorption.

Fluorouracil

Can inhibit the phosphorylation of thiamine, leading to thiamine deficiency.

Diuretics (e.g., Furosemide)

May increase urinary excretion of thiamine.

Storage

Store below 30°C in a dry place, away from light. Keep out of reach of children.

Overdose

Thiamine is generally non-toxic even at high doses due to its water-soluble nature and rapid excretion. Symptoms of extreme overdose are rare but may include headache, insomnia, irritability, and rapid pulse. Treatment is generally supportive.

Pregnancy & Lactation

Generally considered safe for use in recommended doses during pregnancy and lactation. Thiamine is an essential nutrient. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 x 10 tablets (100 tablets)3 x 10 tablets (30 tablets)

Shelf Life

36 months from manufacturing date.

Availability

Pharmacies, drugstores

Approval Status

Approved

Patent Status

Generic

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied and widely used for decades. New clinical trials focus on specific deficiency populations or novel formulations.

Lab Monitoring

Measurement of erythrocyte transketolase activity
Urinary thiamine excretion levels

Doctor Notes

Counsel patients on dietary sources of thiamine.
Be aware of conditions like chronic alcoholism that increase thiamine requirements.

Patient Guidelines

Take as directed by your healthcare provider.
Do not exceed the recommended dose.
Store in a cool, dry place away from direct sunlight.

Missed Dose Advice

If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.