Medicine Information

Anpar-1 Cream

Name: Anpar-1 Cream
Brand: Anpar-1 Cream
Rating: 4.5 (117 reviews)

Cream1%Corticosteroids (Topical)ATC: D07AA02

Generic Name

Hydrocortisone Acetate

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
anpar 1 cream	৳ 35.00	N/A

Description

Overview of the medicine

Anpar-1 Cream is a low-potency topical corticosteroid containing Hydrocortisone Acetate 1%. It is used to reduce inflammation, itching, and redness associated with various skin conditions such as eczema and dermatitis.

Uses & Indications

Eczema

Dermatitis (e.g., contact dermatitis, atopic dermatitis)

Mild to moderate psoriasis

Insect bites

Allergic skin reactions

Pruritus (itching)

Dosage

Adults

Apply a thin layer to the affected area 2-3 times daily. Rub in gently and completely. Do not use for more than 7 days without medical advice.

Elderly

No specific dose adjustment required. Use with caution due to thinner skin and increased potential for side effects.

Renal_impairment

No specific dose adjustment required for topical use, as systemic absorption is minimal.

How to Take

For external use only. Wash hands thoroughly before and after application. Apply a small amount to the affected skin and gently rub in until it disappears. Do not apply to eyes, mouth, or open wounds. Avoid applying under occlusive dressings unless advised by a doctor.

Mechanism of Action

Hydrocortisone Acetate works by inhibiting the release of chemicals that cause inflammation, such as prostaglandins and leukotrienes. It also constricts blood vessels and suppresses immune responses locally in the skin.

Pharmacokinetics

Onset

Anti-inflammatory effects typically manifest within hours of initial application.

Excretion

Mainly through kidneys as inactive metabolites; some biliary excretion also occurs.

Half life

Approximately 8-12 hours in skin tissue, but systemic half-life is shorter due to rapid metabolism.

Absorption

Minimal systemic absorption through intact skin; increased absorption with occlusive dressings, inflamed skin, or damaged skin.

Metabolism

Primarily in the liver and locally in the skin to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to hydrocortisone or any component of the formulation
Untreated fungal, bacterial, or viral skin infections (e.g., herpes simplex, varicella)
Perioral dermatitis
Rosacea
Acne vulgaris
Pruritus without inflammation

Drug Interactions

None significant reported for topical hydrocortisone due to minimal systemic absorption.

However, concurrent use of other topical corticosteroids may increase systemic absorption and potential for local or systemic side effects. Avoid concomitant use with other topical preparations on the same area unless prescribed.

Storage

Store below 30°C in a cool, dry place. Protect from light and moisture. Do not freeze.

Overdose

Acute overdose with topical hydrocortisone is unlikely to produce life-threatening symptoms. However, prolonged or excessive use may lead to systemic effects such as Cushing's syndrome, hyperglycemia, and adrenal suppression. Treatment involves gradual withdrawal of the corticosteroid and symptomatic management.

Pregnancy & Lactation

Use with caution during pregnancy and lactation. Consult a doctor before use. While systemic absorption is minimal, the risk-benefit ratio should be carefully assessed, especially for large body surface areas or prolonged use.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 gm tube15 gm tube20 gm tube

Shelf Life

24 months from manufacturing date, or as specified by manufacturer.

Availability

Pharmacies, Drug Stores

Approval Status

Approved by DGDA/FDA (generic)

Patent Status

Generic, patent expired

WHO Essential Medicine

Yes

Clinical Trials

Hydrocortisone has been extensively studied for its efficacy and safety in various dermatological conditions since its introduction. Specific clinical trials for 'Anpar-1 Cream' would primarily focus on bioequivalence, stability, and local tolerability.

Lab Monitoring

Not routinely required for short-term, localized topical use.
For extensive or prolonged use (especially in children), periodic assessment for hypothalamic-pituitary-adrenal (HPA) axis suppression (e.g., ACTH stimulation test, plasma cortisol levels) may be considered.

Doctor Notes

Emphasize patient education on appropriate application technique, duration of use, and signs of local or systemic side effects.
Advise against using on infected skin without concomitant antimicrobial therapy.
Monitor children closely for signs of systemic absorption and HPA axis suppression if used extensively or for prolonged periods.

Patient Guidelines

Use only as directed by your doctor. Do not exceed the recommended duration of treatment.
Avoid prolonged use on the face, groin, or axillae.
Do not cover treated areas with occlusive dressings (e.g., bandages, tight clothing) unless specifically advised by a doctor.
Keep out of reach of children. Store in a cool, dry place.

Missed Dose Advice

If you miss a dose, apply it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream to compensate for a missed dose.

Driving Precautions

Topical Anpar-1 Cream is not expected to affect the ability to drive or operate machinery, as systemic absorption is minimal.

Lifestyle Advice

Maintain good skin hygiene to prevent secondary infections.
Identify and avoid triggers (e.g., allergens, irritants) that worsen your skin condition.
Moisturize your skin regularly, especially after bathing, if recommended by your doctor.