Medicine Information

Apoxy

Name: Apoxy
Brand: Apoxy
Rating: 4.5 (117 reviews)

Suspension125 mg/5 mlAntibiotic (Penicillin-class)ATC: J01CA04

Generic Name

Amoxicillin

Manufacturer

PharmaGen Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
apoxy 125 mg suspension	৳ 70.00	N/A

Description

Overview of the medicine

Apoxy 125 mg Suspension is an antibiotic from the penicillin group, used to treat various bacterial infections. It works by stopping the growth of bacteria. It is commonly prescribed for infections of the ear, nose, throat, respiratory tract, skin, and urinary tract.

Uses & Indications

Acute otitis media

Acute bacterial sinusitis

Streptococcal pharyngitis/tonsillitis

Lower respiratory tract infections (e.g., bronchitis, pneumonia)

Skin and skin structure infections

Urinary tract infections

Dosage

Adults

Not typically used in adults at this strength; higher strengths or different forms are used. If used, dosage would be individualized.

Elderly

Dosage adjustment may be necessary in elderly patients with impaired renal function.

Renal_impairment

Dosage reduction or extended dosing interval required based on creatinine clearance.

How to Take

Shake the bottle well before each use. Administer orally, with or without food. Complete the full course of medication as prescribed, even if symptoms improve.

Mechanism of Action

Amoxicillin, a beta-lactam antibiotic, inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). This disrupts the peptidoglycan layer, leading to osmotic lysis and bacterial cell death.

Pharmacokinetics

Onset

Within 30 minutes to 1 hour (for symptomatic relief, full antimicrobial effect takes longer)

Excretion

Mainly excreted unchanged in the urine by glomerular filtration and tubular secretion. About 60-80% of a dose is excreted within 6 hours.

Half life

Approximately 1-1.5 hours in adults with normal renal function.

Absorption

Rapidly and well absorbed from the gastrointestinal tract, about 75-90%. Peak plasma concentrations occur within 1-2 hours.

Metabolism

Limited metabolism, approximately 10-25% is metabolized to inactive penicilloic acid.

Side Effects

Contraindications

Hypersensitivity to amoxicillin, any other penicillin, or any component of the formulation.
History of a severe hypersensitivity reaction to another beta-lactam antibiotic (e.g., cephalosporins, carbapenems).

Drug Interactions

Warfarin

May increase the anticoagulant effect of warfarin. Monitor INR.

Methotrexate

May increase methotrexate toxicity due to reduced renal excretion of methotrexate.

Oral contraceptives

May reduce the efficacy of oral contraceptives. Advise use of alternative contraception.

Storage

Store dry powder at room temperature (below 30°C) in a dry place, away from light. Once reconstituted, store in the refrigerator (2-8°C) and discard after specified period.

Overdose

Symptoms of overdose may include gastrointestinal symptoms (nausea, vomiting, diarrhea) and disturbances in fluid and electrolyte balance. In rare cases, crystalluria may be observed leading to renal failure. Treatment is largely symptomatic and supportive. Hemodialysis may be used to remove amoxicillin from circulation.

Pregnancy & Lactation

Amoxicillin is generally considered safe during pregnancy (Category B) and lactation. Consult a doctor before use.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 ml bottle60 ml bottle

Shelf Life

36 months (unreconstituted powder). 7-14 days (reconstituted suspension) when stored in refrigerator.

Availability

Pharmacies, Hospitals

Approval Status

Approved (Amoxicillin)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied and widely used since its approval. Numerous clinical trials have confirmed its efficacy and safety for bacterial infections.

Lab Monitoring

Liver function tests (in patients with hepatic impairment or during prolonged therapy)
Renal function tests (in patients with renal impairment or during prolonged therapy)
Complete blood count (during prolonged therapy)

Doctor Notes

Counsel patients on the importance of completing the full antibiotic course.
Advise parents on proper measurement and administration of the suspension.
Be aware of potential hypersensitivity reactions, especially in patients with a history of penicillin allergy.

Patient Guidelines

Always complete the full course of medication, even if you feel better, to prevent antibiotic resistance.
Shake the suspension well before each use.
Measure the dose accurately using the provided measuring spoon or dropper.
Store the reconstituted suspension in the refrigerator.
Do not share your medication with others.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.