Medicine Information

aristoderm

Name: aristoderm
Brand: aristoderm
Rating: 4.5 (117 reviews)

Cream0.05% w/wTopical CorticosteroidsATC: D07AC01

Generic Name

Betamethasone Valerate 0.05% Cream

Manufacturer

Aristopharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
aristoderm 005 1 cream	৳ 75.00	N/A

Description

Overview of the medicine

Aristoderm-005-1-cream is a topical corticosteroid used to reduce inflammation, itching, and redness associated with various skin conditions like eczema, psoriasis, and dermatitis.

Uses & Indications

Eczema (atopic, discoid, stasis)

Psoriasis (excluding widespread plaque psoriasis)

Lichen planus

Prurigo nodularis

Seborrhoeic dermatitis

Dosage

Adults

Apply a thin film to the affected skin area once or twice daily, as directed by a physician. Do not use for more than 2-4 weeks without medical review.

Elderly

Same as adults, but caution should be exercised due to potentially thinner skin and increased systemic absorption risk.

Renal_impairment

No specific dosage adjustment is generally required for topical use, but caution advised if extensive application or compromised skin barrier.

How to Take

For external use only. Apply a small amount to the affected skin area and rub in gently. Wash hands before and after application. Avoid contact with eyes, mouth, and other mucous membranes. Do not apply to broken or infected skin without medical advice.

Mechanism of Action

Betamethasone valerate, a potent corticosteroid, acts by inducing phospholipase A2 inhibitory proteins, called lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.

Pharmacokinetics

Onset

Local anti-inflammatory effects usually observed within hours to days of application.

Excretion

Excreted renally as metabolites.

Half life

Not well-defined for topical application due to variable systemic absorption; systemically absorbed corticosteroids are metabolized and excreted.

Absorption

Systemic absorption of topical corticosteroids can occur, especially with prolonged use, large surface areas, or occlusive dressings. Absorption varies by site, vehicle, and skin integrity.

Metabolism

Primarily metabolized in the liver, also in the skin.

Side Effects

Contraindications

Hypersensitivity to betamethasone valerate or any component of the cream
Untreated cutaneous infections (bacterial, fungal, viral, parasitic)
Rosacea
Acne vulgaris
Perioral dermatitis
Pruritus without inflammation

Drug Interactions

CYP3A4 inhibitors

Co-administration with potent CYP3A4 inhibitors (e.g., ritonavir, itraconazole) may increase systemic exposure of corticosteroids.

Storage

Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.

Overdose

Topical overdose is unlikely to produce systemic effects, but chronic overuse or misuse can lead to systemic corticosteroid effects (e.g., Cushing's syndrome, adrenal suppression). Treatment is symptomatic and supportive.

Pregnancy & Lactation

Use during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Consult a doctor. In lactating mothers, use with caution, avoiding application to the breasts or areas where the infant might ingest the medicine.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10g tube15g tube

Shelf Life

24 months from manufacturing date.

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Generic

WHO Essential Medicine

Yes

Clinical Trials

Betamethasone valerate is a well-established corticosteroid, and extensive clinical trials support its efficacy and safety for various dermatological conditions.

Lab Monitoring

Not routinely required for short-term topical use. For prolonged or extensive use, monitoring for hypothalamic-pituitary-adrenal (HPA) axis suppression may be considered.

Doctor Notes

Educate patients on proper application technique and duration to minimize local and systemic side effects.
Advise gradual withdrawal for chronic use to avoid rebound flares.
Monitor for signs of infection or skin atrophy.

Patient Guidelines

Apply sparingly and only to the affected area.
Do not cover the treated area with bandages or other occlusive dressings unless specifically instructed by your doctor.
Avoid using on the face, groin, or armpits unless directed by your doctor.
Do not use for more than the prescribed duration.

Missed Dose Advice

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.