Aroflo
Generic Name
Salmeterol
Manufacturer
Example Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| aroflo 50 mcg inhalation capsule | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Aroflo 50 mcg Inhalation Capsule contains salmeterol, a long-acting beta2-adrenergic agonist (LABA), used for the maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD). It helps to relax the muscles around the airways, making them open and easier to breathe.
Uses & Indications
Dosage
Adults
One 50 mcg capsule inhaled twice daily (morning and evening), approximately 12 hours apart.
Elderly
No dosage adjustment required.
Renal_impairment
No dosage adjustment required.
How to Take
For oral inhalation only. Do not swallow the capsule. Administer using a suitable dry powder inhaler device. Follow the instructions provided with the inhaler device carefully. It should be used regularly, even when symptom-free, for full benefit.
Mechanism of Action
Salmeterol is a selective, long-acting beta2-adrenergic receptor agonist (LABA). It acts locally in the lungs to relax bronchial smooth muscle by stimulating beta2 receptors, leading to bronchodilation. Its long duration of action is due to its lipophilicity, allowing it to bind to an 'exo-site' on the receptor and continuously stimulate it.
Pharmacokinetics
Onset
Within 10-20 minutes
Excretion
Mainly via feces (60%) and urine (25%) over 72 hours.
Half life
Approximately 5.5 hours
Absorption
Systemic absorption is minimal following inhalation; however, some portion is absorbed from the lungs and gut.
Metabolism
Primarily hepatic, via hydroxylation by cytochrome P450 3A4 (CYP3A4).
Side Effects
Contraindications
- Primary treatment of status asthmaticus or acute episodes of asthma or COPD requiring intensive measures
- Hypersensitivity to salmeterol or any component of the formulation
Drug Interactions
Diuretics
ECG changes and/or hypokalemia may result from concomitant administration. Use with caution.
Beta-blockers
May block the pulmonary effect of salmeterol and produce severe bronchospasm in asthmatic patients. Should not be used concomitantly.
Tricyclic antidepressants & MAOIs
May potentiate the effect of salmeterol on the cardiovascular system. Use with extreme caution.
CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir)
May increase salmeterol systemic exposure, leading to increased risk of cardiovascular adverse effects. Use with caution or avoid.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include tremor, palpitations, tachycardia, headache, and hypokalemia. Treatment is symptomatic and supportive, including discontinuation of the drug and appropriate monitoring.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown whether salmeterol is excreted in human milk. Exercise caution when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies (e.g., FDA, EMA, DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established the efficacy and safety of salmeterol in the long-term management of asthma and COPD.
Lab Monitoring
- Monitor pulmonary function (FEV1, peak flow)
- Monitor serum potassium levels (especially in patients with hypokalemia or on concomitant diuretics)
Doctor Notes
- Emphasize the importance of concomitant inhaled corticosteroid for asthma patients.
- Counsel patients on correct inhaler technique.
- Monitor for signs of cardiovascular adverse effects, especially in patients with pre-existing cardiac conditions.
Patient Guidelines
- Do not use Aroflo for acute symptoms. It is a long-acting medicine for maintenance therapy.
- Always use an inhaled corticosteroid in conjunction with Aroflo for asthma.
- Rinse your mouth with water after each use to reduce the risk of oral thrush.
- Ensure you understand how to use your inhaler device correctly.
Missed Dose Advice
If a dose is missed, take the next dose at the regular time. Do not take a double dose to make up for a missed one.
Driving Precautions
Aroflo is unlikely to affect the ability to drive or operate machinery. However, if you experience side effects like dizziness or tremor, avoid driving.
Lifestyle Advice
- Avoid smoking, as it can worsen respiratory conditions.
- Maintain good hydration.
- Regularly monitor your peak flow readings if advised by your doctor.
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Global Brand Names
International brand names for this medicine
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