Azilpres Plus

Take the tablet orally once daily with or without food. It should be swallowed whole with a glass of water. Try to take it at the same time each day to maintain consistent blood levels.

Azilsartan Medoxomil is a prodrug that is converted to Azilsartan, an angiotensin II receptor blocker (ARB). It selectively blocks the binding of angiotensin II to the AT1 receptor in many tissues, including vascular smooth muscle and the adrenal gland. This inhibits the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to vasodilation and reduced blood pressure. Chlorthalidone is a thiazide-like diuretic that acts on the distal convoluted tubule of the kidney to inhibit sodium and chloride reabsorption, leading to increased excretion of sodium, chloride, and water, thereby reducing plasma volume and blood pressure.

• Hypersensitivity to Azilsartan, Chlorthalidone, or any component of the formulation
• Anuria (absence of urine production)
• Severe renal impairment (creatinine clearance <30 mL/min)
• Pregnancy (second and third trimesters)
• Concomitant use with Aliskiren in patients with diabetes mellitus or renal impairment (GFR <60 mL/min/1.73 m²)
• Severe hepatic impairment

Store in a cool, dry place, away from direct light and moisture. Keep out of reach of children. Store below 30°C.

Symptoms of overdose may include profound hypotension, dizziness, and electrolyte disturbances (e.g., hypokalemia, hyponatremia). Treatment is supportive and symptomatic. If ingestion is recent, gastric lavage may be considered. Closely monitor vital signs and serum electrolytes.

Contraindicated during the second and third trimesters of pregnancy due to risk of fetal harm. Not recommended during breastfeeding as it is unknown if Azilsartan is excreted in human milk, and chlorthalidone is excreted in milk.