Medicine Information

B-Vita 4.5

Name: B-Vita 4.5
Brand: B-Vita 4.5
Rating: 4.5 (117 reviews)

Tablet4.5 mgVitamin B-complex / VitaminsATC: A11HA02

Generic Name

Pyridoxine Hydrochloride (Vitamin B6)

Manufacturer

Generic Pharma Inc.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
b vit 4 5 mg tablet	৳ 86.00	N/A

Description

Overview of the medicine

B-Vit 4.5 mg Tablet contains Pyridoxine Hydrochloride (Vitamin B6), an essential water-soluble vitamin vital for numerous bodily functions including metabolism, nerve function, and red blood cell formation. It is used to prevent or treat Vitamin B6 deficiency.

Uses & Indications

Prevention and treatment of Vitamin B6 deficiency.

Supplementation in conditions leading to B6 deficiency (e.g., alcoholism, malabsorption syndromes).

Management of peripheral neuropathy induced by certain drugs (e.g., Isoniazid).

Relief of nausea and vomiting in pregnancy (often in combination with doxylamine).

Dosage

Adults

For dietary supplementation, typically 2-5 mg per day. For treatment of deficiency, doses may vary, consult a healthcare professional. This 4.5 mg tablet is suitable for daily supplementation.

Elderly

Similar to adult dosage. No specific adjustment is generally required unless there is significant renal impairment requiring monitoring at higher doses.

Renal_impairment

No specific dosage adjustment is usually needed for 4.5 mg. For higher therapeutic doses, caution is advised, and monitoring may be necessary.

How to Take

Take orally, with or without food, as directed by your doctor or as indicated on the package.

Mechanism of Action

Pyridoxine (Vitamin B6) acts as a coenzyme in various metabolic pathways, primarily in amino acid, carbohydrate, and fat metabolism. It is crucial for neurotransmitter synthesis (e.g., serotonin, dopamine), hemoglobin synthesis, and glycogenolysis.

Pharmacokinetics

Onset

Therapeutic effects may be gradual, depending on the severity of deficiency.

Excretion

Excreted renally, primarily as 4-pyridoxic acid (the main inactive metabolite) and other inactive metabolites. A small amount is excreted unchanged.

Half life

Approximately 15-20 days for pyridoxal 5'-phosphate (the active form).

Absorption

Rapidly absorbed from the gastrointestinal tract, primarily in the jejunum. Peak plasma concentrations reached within 1-2 hours.

Metabolism

Primarily in the liver, converted to the active coenzyme forms, pyridoxal phosphate (PLP) and pyridoxamine phosphate (PMP).

Side Effects

Contraindications

Hypersensitivity to Pyridoxine or any component of the formulation.

Drug Interactions

Levodopa

Pyridoxine may decrease the effectiveness of Levodopa (without carbidopa) in Parkinson's disease treatment.

Phenytoin, Phenobarbital

Pyridoxine may lower serum concentrations of these anticonvulsants.

Isoniazid, Penicillamine, Hydralazine, Cycloserine

These drugs are B6 antagonists and can increase pyridoxine requirements, potentially leading to deficiency.

Storage

Store below 30°C in a cool, dry place, protected from light and moisture. Do not freeze.

Overdose

Acute overdose is rare and generally not toxic at high doses. However, chronic intake of very high doses (e.g., >100-200 mg/day for prolonged periods) can lead to sensory neuropathy, ataxia, and skin lesions.

Pregnancy & Lactation

Pyridoxine is generally considered safe and is often recommended during pregnancy, especially for managing nausea and vomiting. It is also safe during lactation, as breast milk provides adequate B6 to the infant.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 x 10 tablets (100 tablets in a box)30 tablets in a bottle

Shelf Life

2-3 years from the date of manufacture, refer to the package for exact expiry date.

Availability

Pharmacies, drugstores, supermarkets

Approval Status

Approved (Generally Recognized as Safe and Effective)

Patent Status

Generic

WHO Essential Medicine

Yes

Clinical Trials

Pyridoxine has been extensively studied for its role in preventing and treating B6 deficiency, managing certain neuropathies, and its use in pregnancy-related nausea. Numerous clinical trials support its efficacy and safety at appropriate doses.

Lab Monitoring

Routine lab monitoring is not typically required for individuals taking 4.5 mg Pyridoxine. In cases of suspected deficiency or very high therapeutic doses, plasma pyridoxal 5'-phosphate (PLP) levels may be monitored.

Doctor Notes

Pyridoxine is an essential vitamin, crucial for metabolic functions and nervous system health.
Recommend for confirmed B6 deficiency or as a daily supplement for at-risk individuals.
Advise patients about potential interaction with Levodopa (if prescribed for Parkinson's without carbidopa).
Caution against excessive self-medication with high doses due to neuropathy risk.

Patient Guidelines

Take the tablet whole with water.
Do not exceed the recommended dose without consulting a doctor.
Store in a cool, dry place away from direct sunlight.
Keep out of reach of children.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Pyridoxine 4.5 mg is not known to affect the ability to drive or operate machinery.

Lifestyle Advice

Maintain a balanced diet rich in B vitamins (e.g., meat, fish, poultry, potatoes, non-citrus fruits).
Avoid excessive alcohol consumption, as it can deplete B vitamin levels.