Medicine Information

Bacaid

Name: Bacaid
Brand: Bacaid
Rating: 4.5 (117 reviews)

Tablet5 mgCentrally acting muscle relaxantsATC: M03BX01

Generic Name

Baclofen

Manufacturer

Local Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
bacaid 5 mg tablet	৳ 5.50	৳ 55.00

Description

Overview of the medicine

Bacaid 5 mg Tablet contains Baclofen, a muscle relaxant used to treat spasticity (muscle stiffness and tightness) resulting from various neurological conditions like multiple sclerosis, spinal cord injuries, or cerebral palsy. It helps to relieve muscle spasms, pain, and improve muscle movement.

Uses & Indications

Spasticity associated with multiple sclerosis

Spasticity associated with spinal cord injuries and diseases

Spasticity associated with cerebral palsy

Other spasticity of cerebral origin

Dosage

Adults

Initial dose is 5 mg three times daily, gradually increased by 5 mg increments every 3 days to a maximum of 20 mg three times daily (total 60 mg/day). Max recommended dose is 100 mg/day.

Elderly

Lower starting dose (e.g., 5 mg twice daily) and slower titration are recommended due to increased sensitivity and potential for adverse effects.

Renal_impairment

Dose reduction is necessary. Initial dose should be 5 mg once daily, and subsequent doses should be adjusted cautiously based on response and renal function.

How to Take

Bacaid 5 mg Tablet should be taken orally with food or milk to minimize gastrointestinal upset. It is recommended to take it at regular intervals throughout the day.

Mechanism of Action

Baclofen acts as a GABA-B receptor agonist in the spinal cord. It inhibits both mono- and polysynaptic reflexes, leading to decreased excitability of motor neurons and reduced muscle spasticity.

Pharmacokinetics

Onset

Onset of action typically within 1-2 hours.

Excretion

Primarily excreted unchanged by the kidneys (70-80% of the dose) within 72 hours.

Half life

Plasma elimination half-life ranges from 3-4 hours.

Absorption

Rapid and complete absorption from the gastrointestinal tract. Peak plasma concentrations are reached within 2-3 hours.

Metabolism

Minimal hepatic metabolism, with less than 15% of the dose undergoing metabolism.

Side Effects

Contraindications

Hypersensitivity to baclofen or any component of the formulation.
Epilepsy that is not adequately controlled.

Drug Interactions

Antihypertensives

Concurrent use may result in an additive hypotensive effect, requiring blood pressure monitoring.

Levodopa/Carbidopa

Possible exacerbation of symptoms in patients with Parkinson's disease.

Tricyclic antidepressants

May potentiate the hypotensive and muscle relaxant effects of baclofen.

CNS depressants (alcohol, opioids, benzodiazepines)

Concomitant use may increase CNS depression, leading to enhanced drowsiness, sedation, and respiratory depression.

Storage

Store below 30°C in a dry place. Protect from moisture, heat, and direct light. Keep out of reach of children.

Overdose

Symptoms of overdose include severe drowsiness, confusion, visual hallucinations, respiratory depression, seizures, and coma. Management is supportive, including gastric lavage or induced emesis, and maintaining adequate respiration and cardiovascular function. Activated charcoal may be considered.

Pregnancy & Lactation

Pregnancy Category C. Baclofen should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk in small amounts; caution is advised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 Tablets (Blister Pack)30 Tablets (Blister Pack)100 Tablets (Blister Pack)

Shelf Life

Generally 2-3 years from the date of manufacturing, but always refer to the expiry date on the packaging.

Availability

Pharmacies, hospitals

Approval Status

DGDA/FDA Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Baclofen has undergone extensive clinical trials demonstrating its efficacy and safety in managing spasticity across various neurological disorders. Studies have evaluated different dosing regimens, routes of administration (oral and intrathecal), and long-term outcomes.

Lab Monitoring

Periodic monitoring of liver function tests is recommended, especially in patients with pre-existing liver disease.
Renal function tests should be monitored, particularly in patients with renal impairment.

Doctor Notes

Start with a low dose and titrate gradually to minimize side effects and find the optimal therapeutic dose.
Counsel patients on the importance of gradual withdrawal to prevent severe withdrawal symptoms.
Monitor for CNS depression and respiratory compromise, especially when co-administered with other depressants.
Assess renal function regularly, particularly in elderly patients or those with kidney impairment, and adjust the dose accordingly.

Patient Guidelines

Do not stop taking Bacaid 5 mg Tablet abruptly, as it can lead to severe withdrawal symptoms. Always follow your doctor's instructions for dose reduction.
Avoid consuming alcohol or other CNS depressants while taking this medicine, as it can increase drowsiness and sedation.
Be cautious when performing tasks that require mental alertness, such as driving or operating machinery, until you know how this medicine affects you.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Bacaid 5 mg Tablet may cause drowsiness, dizziness, or blurred vision. Patients should be advised not to drive or operate machinery or engage in other activities requiring mental alertness until they know how this medicine affects them.

Lifestyle Advice

Engage in regular physical therapy or other rehabilitative exercises as recommended by your doctor to complement the effects of baclofen.
Maintain a balanced diet and adequate hydration to support overall health and minimize potential side effects.