Medicine Information

Bacmax

Name: Bacmax
Brand: Bacmax
Rating: 4.5 (117 reviews)

Tablet5 mgMuscle relaxantsATC: M03BX01

Generic Name

Baclofen

Manufacturer

Hypothetical Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
bacmax 5 mg tablet	৳ 4.50	৳ 63.00

Description

Overview of the medicine

Bacmax 5 mg Tablet contains Baclofen, a muscle relaxant used to treat muscle spasms, stiffness, and pain caused by certain neurological conditions like multiple sclerosis or spinal cord injuries.

Uses & Indications

Treatment of spasticity resulting from multiple sclerosis

Treatment of spasticity resulting from spinal cord injuries and other spinal cord diseases

Management of severe chronic spasticity

Dosage

Adults

Initially 5 mg three times daily for 3 days, then 10 mg three times daily for 3 days, increasing gradually to a maximum of 20 mg three times daily. Max dose 80 mg/day.

Elderly

Start with a lower dose (e.g., 5 mg once daily) and titrate slowly due to increased sensitivity and potential for adverse effects.

Renal_impairment

Dose reduction required; administer 5 mg once daily, increasing cautiously based on response and renal function.

How to Take

Take orally with food or milk to minimize gastrointestinal discomfort. Do not stop suddenly, as it can cause withdrawal symptoms.

Mechanism of Action

Baclofen acts as a GABA-B receptor agonist in the spinal cord, inhibiting both monosynaptic and polysynaptic reflexes. This leads to a reduction in hyperactive reflexes and muscle spasms, thereby relaxing skeletal muscles.

Pharmacokinetics

Onset

Within 1-2 hours

Excretion

Mainly excreted unchanged in the urine (70-80%), with a small amount excreted via feces.

Half life

Approximately 3-4 hours

Absorption

Rapidly and extensively absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 2-3 hours.

Metabolism

Minimally metabolized in the liver (about 15%)

Side Effects

Contraindications

Hypersensitivity to baclofen or any component of the formulation
Epilepsy (use with caution)

Drug Interactions

Antihypertensives

Additive hypotensive effects.

Tricyclic antidepressants

May enhance muscle hypotonia.

CNS depressants (alcohol, opioids, benzodiazepines)

Increased CNS depression, drowsiness, respiratory depression.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms include drowsiness, lightheadedness, dizziness, profound muscle hypotonia, respiratory depression, seizures, and coma. Management involves supportive care, gastric lavage if recent ingestion, and respiratory support.

Pregnancy & Lactation

Pregnancy category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk in small amounts; use with caution during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

30 tablets100 tablets

Shelf Life

24 months

Availability

Pharmacies, hospitals, clinics

Approval Status

Approved by FDA and DGDA

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have demonstrated baclofen's efficacy in reducing spasticity and improving motor function in various neurological conditions. Recent trials focus on optimal dosing and formulations.

Lab Monitoring

Renal function tests (especially in patients with renal impairment)
Liver function tests (periodically, though rare)
Blood pressure monitoring

Doctor Notes

Counsel patients on potential for drowsiness and muscle weakness.
Emphasize the importance of gradual dose reduction when discontinuing.
Monitor renal function, especially in elderly and impaired patients.

Patient Guidelines

Take as directed by your doctor. Do not stop taking this medicine suddenly.
Avoid alcohol and other CNS depressants.
Be cautious when driving or operating machinery until you know how this medicine affects you.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.