Medicine Information

Bacspa

Name: Bacspa
Brand: Bacspa
Rating: 4.5 (117 reviews)

Tablet10 mgSkeletal Muscle RelaxantsATC: M03BX01

Generic Name

Baclofen

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
bacspa 10 mg tablet	৳ 8.00	৳ 80.00

Description

Overview of the medicine

Bacspa 10 mg Tablet contains Baclofen, a muscle relaxant used to treat muscle spasticity arising from various conditions like multiple sclerosis, spinal cord injury, or cerebral palsy. It works by acting on nerve pathways in the spinal cord to reduce muscle spasms and restore muscle function.

Uses & Indications

Management of spasticity resulting from multiple sclerosis

Spasticity of spinal cord origin (e.g., spinal cord injury, neoplastic, degenerative and traumatic conditions)

Cerebral spasticity (e.g., cerebral palsy, stroke, traumatic brain injury)

Dosage

Adults

Initially 5 mg three times daily for 3 days, then increased by 5 mg increments every 3 days. Typical maintenance dose: 30-75 mg/day in divided doses. Max: 80 mg/day.

Elderly

Lower initial doses (e.g., 5 mg once or twice daily) and slower titration recommended due to increased sensitivity and potential for impaired renal function.

Renal_impairment

Dosage should be significantly reduced; consider 5 mg daily or every other day, monitoring renal function closely. Titrate carefully based on response and tolerability.

How to Take

Bacspa 10 mg Tablet should be taken orally, preferably with food or milk to minimize gastrointestinal upset. Do not chew or crush the tablet. It is important not to discontinue the medication abruptly.

Mechanism of Action

Baclofen acts as an agonist at GABAB receptors, particularly at the spinal cord level. It inhibits both monosynaptic and polysynaptic reflexes, reducing the release of excitatory neurotransmitters and hyperpolarizing neurons, leading to decreased skeletal muscle spasticity.

Pharmacokinetics

Onset

Onset of action is typically within 1-2 hours.

Excretion

Primarily excreted by the kidneys (approximately 70-80% as unchanged drug) within 72 hours.

Half life

The elimination half-life ranges from 2.5 to 4 hours.

Absorption

Rapidly and extensively absorbed from the gastrointestinal tract. Peak plasma concentrations are achieved within 2-3 hours.

Metabolism

Only about 5-15% of the dose is metabolized in the liver; the remainder is excreted unchanged.

Side Effects

Contraindications

Hypersensitivity to baclofen or any component of the formulation
Acute porphyria

Drug Interactions

Antihypertensives

Additive hypotensive effects may occur, requiring dosage adjustment.

Levodopa/Carbidopa

Exacerbation of parkinsonian symptoms has been reported in some patients.

Tricyclic Antidepressants, MAOIs

Enhanced CNS depression and possible potentiation of hypotensive effects.

CNS Depressants (e.g., alcohol, opioids, benzodiazepines)

Increased central nervous system (CNS) depression, including sedation and respiratory depression.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include drowsiness, dizziness, severe muscle hypotonia, respiratory depression, seizures, and coma. Management is supportive, involving maintaining an open airway, cardiovascular support, and hydration. There is no specific antidote for baclofen overdose.

Pregnancy & Lactation

Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Baclofen is excreted in breast milk; caution should be exercised when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets (1x10's)30 tablets (3x10's)50 tablets (5x10's)

Shelf Life

24 months from the date of manufacture

Availability

Pharmacies, Hospitals

Approval Status

Approved by regulatory authorities (e.g., DGDA)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Numerous clinical trials have confirmed the efficacy and safety of baclofen in treating spasticity of various origins, showing significant reduction in spasm frequency and severity, and improvement in functional status.

Lab Monitoring

Renal function tests (blood urea nitrogen and creatinine) in patients with impaired renal function or elderly.
Liver function tests (ALT, AST) periodically for patients on long-term therapy.

Doctor Notes

Initiate baclofen therapy with a low dose and titrate slowly to optimal effect while minimizing adverse events.
Emphasize to patients and caregivers the critical importance of gradual dose reduction upon discontinuation to prevent severe withdrawal symptoms.
Monitor for signs of CNS depression, especially when co-administered with other CNS depressants. Adjust dose in renal impairment.

Patient Guidelines

Take Bacspa exactly as prescribed by your doctor; do not change the dose or stop abruptly without consulting your doctor.
This medicine may cause drowsiness or dizziness; avoid activities requiring mental alertness such as driving or operating machinery.
Inform your doctor about all other medications, herbal products, and supplements you are taking to avoid potential drug interactions.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Bacspa can cause drowsiness, dizziness, and decreased mental alertness. Patients should be warned not to drive, operate hazardous machinery, or engage in activities requiring full mental alertness until they know how the drug affects them.

Lifestyle Advice

Avoid alcohol and other central nervous system depressants during treatment.
Regular physical therapy and stretching exercises can complement the effects of Bacspa.
Maintain adequate hydration and a balanced diet.