Medicine Information

Bakticef

Name: Bakticef
Brand: Bakticef
Rating: 4.5 (117 reviews)

Injection500 mgAntibiotics (Third Generation Cephalosporins)ATC: J01DD04

Generic Name

Ceftriaxone 500 mg Injection

Manufacturer

Medicon Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
bakticef 500 mg injection	৳ 155.00	N/A

Description

Overview of the medicine

Bakticef 500 mg Injection is a third-generation cephalosporin antibiotic used to treat various bacterial infections.

Uses & Indications

Lower respiratory tract infections

Skin and soft tissue infections

Urinary tract infections

Intra-abdominal infections

Sepsis/Septicemia

Meningitis

Surgical prophylaxis

Dosage

Adults

Typically 1-2 g once daily, up to 4 g/day in severe cases. Administered IM or IV.

Elderly

No specific dose adjustment is needed unless severe renal or hepatic impairment is present.

Renal_impairment

Dose adjustment may be necessary in severe renal impairment (creatinine clearance <10 mL/min).

How to Take

Administered as an intramuscular (IM) or intravenous (IV) injection by a healthcare professional.

Mechanism of Action

Ceftriaxone works by inhibiting bacterial cell wall synthesis, leading to bacterial cell death.

Pharmacokinetics

Onset

Rapid onset of action, typically within minutes after IV administration.

Excretion

Approximately 33-67% is excreted unchanged via renal route, and the remainder via biliary/fecal route.

Half life

Approximately 5.8 to 8.7 hours.

Absorption

Rapid and complete absorption after intramuscular (IM) or intravenous (IV) administration. Bioavailability is approximately 100%.

Metabolism

Not extensively metabolized; primarily converted to inactive metabolites in the intestine.

Side Effects

Contraindications

Hypersensitivity to cephalosporins or penicillins
Neonates with hyperbilirubinemia, especially premature neonates
Concomitant use with calcium-containing IV solutions in neonates

Drug Interactions

Warfarin

May increase the risk of bleeding. Monitor INR.

Loop diuretics

Increased risk of nephrotoxicity.

Aminoglycosides

Increased risk of nephrotoxicity. Monitor renal function.

Oral contraceptives

May reduce the efficacy of oral contraceptives. Advise alternative contraception.

Storage

Store below 30°C, protect from light. Reconstituted solution should be used immediately or within a limited time as specified by the manufacturer.

Overdose

In case of overdose, provide symptomatic and supportive treatment. Hemodialysis or peritoneal dialysis is not effective for ceftriaxone removal.

Pregnancy & Lactation

Pregnancy Category B. Use with caution during lactation as it is excreted in breast milk.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

500 mg vial + solvent1 g vial + solvent

Shelf Life

Typically 2-3 years, refer to the product packaging for specific expiration date.

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic

WHO Essential Medicine

Yes

Clinical Trials

Ceftriaxone has undergone extensive clinical trials demonstrating its efficacy and safety in treating a wide range of bacterial infections.

Lab Monitoring

Complete Blood Count (CBC)
Renal and hepatic function tests
Prothrombin time (especially with high doses or renal impairment)

Doctor Notes

Always inquire about patient's allergy history, especially to beta-lactam antibiotics.
Monitor renal and hepatic function during prolonged therapy.
Avoid concurrent IV calcium administration in neonates to prevent fatal precipitation.

Patient Guidelines

Complete the full course of treatment as prescribed by your doctor.
Report any unusual side effects to your doctor immediately.
Do not share your medicine with others.

Missed Dose Advice

If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.