Medicine Information

Benalgin

Name: Benalgin
Brand: Benalgin
Rating: 4.5 (117 reviews)

Suspension120 mg/5 mlAnalgesic, AntipyreticATC: N02BE01

Generic Name

Paracetamol 120 mg/5ml Suspension

Manufacturer

Eskayef Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
benalgin 120 mg suspension	৳ 35.00	N/A

Description

Overview of the medicine

Benalgin 120 mg suspension is a widely used medication containing Paracetamol, an analgesic and antipyretic agent. It is primarily used to relieve mild to moderate pain and reduce fever, especially in infants and children.

Uses & Indications

Mild to moderate pain relief (e.g., headache, toothache, muscle pain, menstrual pain)

Fever reduction (e.g., associated with colds, flu, vaccinations)

Pain and fever associated with common childhood illnesses

Dosage

Adults

Not typically used for adults in this strength. For adult use, higher strength tablets are preferred (e.g., 500 mg).

Elderly

Not typically used for elderly in this strength. Dosage for elderly with higher strength paracetamol may require adjustment in severe renal impairment.

Renal_impairment

Dose interval may need to be extended in severe renal impairment (CrCl < 10 mL/min) to every 8 hours.

How to Take

Oral administration. Shake the bottle well before use. Use a measuring spoon or oral syringe for accurate dosing. Can be taken with or without food.

Mechanism of Action

Paracetamol is thought to act primarily in the central nervous system, inhibiting prostaglandin synthesis (COX-1 and COX-2) in the brain. It also acts peripherally to block pain impulse generation and has antipyretic effects by acting on the hypothalamic heat-regulating center.

Pharmacokinetics

Onset

Pain relief: 30 minutes to 1 hour; Fever reduction: 30 minutes.

Excretion

Mainly excreted in the urine as glucuronide and sulfate conjugates, with less than 5% excreted as unchanged drug.

Half life

1 to 4 hours (average 2.5 hours); prolonged in overdose or liver disease.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 30 minutes to 2 hours after oral administration.

Metabolism

Primarily metabolized in the liver via glucuronidation and sulfation, with a small portion metabolized by cytochrome P450 into a toxic intermediate (NAPQI) which is rapidly detoxified by glutathione.

Side Effects

Contraindications

Known hypersensitivity to Paracetamol or any other component of the formulation
Severe hepatic impairment or active liver disease

Drug Interactions

Alcohol

Increases the risk of liver damage with chronic heavy alcohol consumption.

Cholestyramine

Reduces the absorption of paracetamol if administered within one hour.

Warfarin and other coumarins

May enhance the anticoagulant effect with prolonged regular daily use, increasing the risk of bleeding.

Metoclopramide and Domperidone

Increase the absorption rate of paracetamol.

Storage

Store below 30°C in a dry place, away from light and moisture. Do not freeze. Keep tightly closed.

Overdose

Symptoms of overdose include nausea, vomiting, abdominal pain, sweating, and loss of appetite. Severe overdose can lead to hepatic necrosis, renal tubular necrosis, cardiac abnormalities, and pancreatitis. Treatment involves gastric lavage, activated charcoal, and administration of N-acetylcysteine (NAC) as an antidote.

Pregnancy & Lactation

Paracetamol is generally considered safe for use during pregnancy and lactation at recommended doses, but always consult a doctor before use.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 ml bottle100 ml bottle

Shelf Life

24-36 months when unopened. Refer to the specific product packaging for exact details after opening.

Availability

Pharmacies, drugstores, hospitals

Approval Status

Approved by DGDA (Bangladesh)

Patent Status

Expired (for Paracetamol)

WHO Essential Medicine

Yes

Clinical Trials

Paracetamol has been extensively studied since its introduction. Numerous clinical trials support its efficacy and safety as an analgesic and antipyretic. Specific trials for 'Benalgin' would be brand-specific and likely focus on bioequivalence.

Lab Monitoring

Liver function tests (in cases of prolonged high-dose therapy or suspected overdose)
Renal function tests (in patients with pre-existing renal impairment or overdose)

Doctor Notes

Emphasize correct dosing, especially in children, to avoid accidental overdose.
Advise parents to use the provided measuring device.
Be aware of concomitant use of other paracetamol-containing products.

Patient Guidelines

Do not exceed the recommended dose.
Do not use with other paracetamol-containing products.
Consult a doctor if symptoms persist for more than 3 days or worsen.
Keep out of reach of children.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.