Benkill-CV
Generic Name
Amoxicillin and Clavulanic Acid
Manufacturer
Local Pharmaceutical Company
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| benkill cv 500 mg tablet | ৳ 60.00 | ৳ 420.00 |
Description
Overview of the medicine
Benkill-CV 500 mg Tablet is a combination antibiotic containing Amoxicillin, a penicillin-type antibiotic, and Clavulanic Acid, a beta-lactamase inhibitor. It is used to treat a wide range of bacterial infections that are resistant to Amoxicillin alone.
Uses & Indications
Dosage
Adults
One Benkill-CV 500 mg/125 mg tablet every 8 hours or as directed by physician. Duration of treatment varies depending on the infection.
Elderly
No specific dose adjustment is usually required unless there is severe renal impairment.
Renal_impairment
Dose adjustment required based on creatinine clearance. For severe impairment (CrCl < 30 mL/min), dose reduction or extended dosing interval is necessary.
How to Take
Take orally with a meal to reduce potential gastrointestinal intolerance. Swallow whole with water; do not crush or chew.
Mechanism of Action
Amoxicillin works by inhibiting bacterial cell wall synthesis, leading to bacterial lysis. Clavulanic Acid protects Amoxicillin from degradation by beta-lactamase enzymes produced by resistant bacteria, thereby extending Amoxicillin's spectrum of activity.
Pharmacokinetics
Onset
Clinical improvement usually observed within 24-48 hours.
Excretion
Primarily excreted unchanged in the urine, mainly by tubular secretion and glomerular filtration.
Half life
Amoxicillin: approximately 1.3 hours; Clavulanic Acid: approximately 1 hour.
Absorption
Both Amoxicillin and Clavulanic Acid are well absorbed orally. Peak plasma concentrations are achieved within 1-2 hours.
Metabolism
Amoxicillin is minimally metabolized. Clavulanic Acid is extensively metabolized.
Side Effects
Contraindications
- Known hypersensitivity to penicillin or any component of the formulation
- History of cholestatic jaundice or hepatic dysfunction associated with amoxicillin/clavulanic acid therapy
Drug Interactions
Warfarin
May prolong prothrombin time; monitor INR closely.
Probenecid
Increases and prolongs plasma levels of amoxicillin.
Methotrexate
Increases methotrexate toxicity.
Oral Contraceptives
May reduce efficacy of oral contraceptives (advise additional contraception).
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include gastrointestinal upset, fluid and electrolyte imbalance, and rarely, convulsions. Treatment is symptomatic and supportive. Hemodialysis can remove both amoxicillin and clavulanic acid from circulation.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy if clearly needed. Excreted in breast milk; observe infants for diarrhea, candidiasis, or skin rash.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by health authorities
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Extensively studied and clinically proven for its efficacy and safety in various bacterial infections.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) in patients with pre-existing hepatic impairment or prolonged treatment
- Renal function tests (creatinine, BUN) in patients with renal impairment
- Complete blood count (CBC) during prolonged therapy
Doctor Notes
- Counsel patients on importance of completing full course to prevent resistance.
- Be aware of potential for hypersensitivity reactions, especially in penicillin-allergic patients.
- Monitor liver function in patients with pre-existing hepatic impairment.
Patient Guidelines
- Complete the full course of treatment as prescribed, even if you feel better.
- Do not share this medication with others.
- If symptoms worsen or do not improve, consult your doctor.
- Report any severe diarrhea or allergic reactions immediately.
Missed Dose Advice
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness; exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain good hydration by drinking plenty of fluids.
- Consume probiotics to help prevent antibiotic-associated diarrhea.
- Avoid alcohol during treatment as it may worsen gastrointestinal side effects.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine
Related
Medicines
Explore similar medicines to find the best option for your healthcare needs.
Avilam
Various (e.g., Sanofi as Avil)
Axovit
Reputable Pharma Ltd.
Exler
Incepta Pharmaceuticals
Azilpres
Specific manufacturer varies by region (e.g., Square Pharmaceuticals Ltd. in BD for a generic Azilsartan product)
Axxo
Square Pharmaceuticals Ltd.
Avloquin-H
General Pharmaceuticals Ltd.
Exopan
Square Pharmaceuticals Ltd.
Exalin
Square Pharmaceuticals Ltd.
Exomi MUPS
Square Pharmaceuticals Ltd.
Lotenate Plus
General Pharmaceuticals Ltd.