Medicine Information

Bestcol

Name: Bestcol
Brand: Bestcol
Rating: 4.5 (117 reviews)

Tablet20 mgHMG-CoA Reductase Inhibitors (Statins)ATC: C10AA07

Generic Name

Rosuvastatin

Manufacturer

Assumed Pharmaceutical Co. Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
bestcol 20 mg tablet	৳ 30.00	৳ 300.00

Description

Overview of the medicine

Bestcol 20 mg tablet contains Rosuvastatin, a medication used to lower high cholesterol and triglycerides in the blood. It helps prevent heart attacks, strokes, and other cardiovascular problems by reducing the amount of 'bad' cholesterol (LDL) and increasing 'good' cholesterol (HDL).

Uses & Indications

Primary hypercholesterolemia (Type IIa, including heterozygous familial hypercholesterolemia) or mixed dyslipidemia (Type IIb)

Homozygous familial hypercholesterolemia

Primary prevention of major cardiovascular events in patients at high risk

Dosage

Adults

Initial dose is usually 5 mg or 10 mg once daily. Max dose 40 mg once daily. For 20 mg: one tablet once daily.

Elderly

No dose adjustment required for patients >70 years unless other risk factors for myopathy exist. Initial dose 5 mg for patients >70 years.

Renal_impairment

Mild to moderate impairment: No dose adjustment needed. Severe impairment (CrCl <30 mL/min): Initial dose 5 mg, max 10 mg daily.

How to Take

Bestcol tablet can be taken orally, once daily, with or without food. It is recommended to take it at the same time each day, preferably in the evening.

Mechanism of Action

Rosuvastatin works by inhibiting HMG-CoA reductase, an enzyme crucial for cholesterol production in the liver. This reduces the synthesis of cholesterol, leading to a decrease in LDL-cholesterol levels and an increase in HDL-cholesterol.

Pharmacokinetics

Onset

Lipid-lowering effects are evident within 1 week, with 90% of maximum response achieved by 2 weeks.

Excretion

Approximately 90% is excreted unchanged in feces, with the remaining 10% excreted in urine.

Half life

Approximately 19 hours.

Absorption

Approximately 20% oral bioavailability. Peak plasma concentrations are reached about 3-5 hours after oral administration.

Metabolism

Limited metabolism, primarily by CYP2C9 to an inactive N-desmethyl metabolite. Main component is unchanged rosuvastatin.

Side Effects

Contraindications

Hypersensitivity to rosuvastatin or any component of the formulation
Active liver disease, including unexplained persistent elevations of serum transaminases
Pregnancy and lactation
Severe renal impairment (CrCl <30 mL/min) at doses of 40 mg
Concomitant use with ciclosporin

Drug Interactions

Warfarin

May enhance anticoagulant effect; monitor INR.

Ciclosporin

Significantly increases rosuvastatin exposure; concomitant use is contraindicated.

Gemfibrozil

Increases rosuvastatin exposure; limit rosuvastatin dose to 10 mg daily.

Niacin (high doses)

Increased risk of myopathy.

Protease inhibitors (e.g., Atazanavir/Ritonavir)

Increased rosuvastatin exposure; dose adjustment may be necessary.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

There is no specific treatment for rosuvastatin overdose. In the event of an overdose, symptomatic treatment and supportive measures should be initiated. Liver function tests and CK levels should be monitored.

Pregnancy & Lactation

Rosuvastatin is contraindicated during pregnancy and lactation. Women of childbearing potential should use effective contraception.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box

Shelf Life

Usually 24-36 months from the date of manufacture.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by regulatory authorities

Patent Status

Off-patent

Clinical Trials

Rosuvastatin has undergone extensive clinical trials demonstrating its efficacy in lowering LDL-C and reducing cardiovascular risk, such as the JUPITER trial.

Lab Monitoring

Liver function tests (LFTs) should be performed before initiation of therapy and periodically thereafter.
Lipid panel should be monitored to assess therapeutic response.
Creatine kinase (CK) levels should be measured if muscle pain or weakness occurs.

Doctor Notes

Counsel patients on lifestyle modifications (diet, exercise) in conjunction with rosuvastatin therapy.
Monitor liver enzymes and lipid profile regularly.
Educate patients about symptoms of myopathy and to report them promptly.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Do not stop taking Bestcol without consulting your doctor.
Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Bestcol is generally not expected to impair the ability to drive or operate machinery. However, some individuals may experience dizziness, so caution is advised until you know how the medicine affects you.