Medicine Information

Brofex-TS

Name: Brofex-TS
Brand: Brofex-TS
Rating: 4.5 (117 reviews)

Extended-Release SuspensionFexofenadine Hydrochloride 30 mg + Pseudoephedrine Hydrochloride 60 mgAntihistamine & DecongestantATC: R01BA52

Generic Name

brofex-ts-30-mg-extend-release-suspension

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
brofex ts 30 mg extend release suspension	৳ 100.00	N/A

Description

Overview of the medicine

Brofex-TS Extended-Release Suspension is a combination medicine containing Fexofenadine and Pseudoephedrine. It is used for the symptomatic relief of seasonal allergic rhinitis including sneezing, runny nose, itchy nose/palate/throat, itchy/watery eyes, and nasal congestion.

Uses & Indications

Symptomatic relief of seasonal allergic rhinitis.

Relief of sneezing, rhinorrhea, nasal itching.

Relief of itchy, watery eyes.

Relief of nasal congestion due to colds or allergies.

Dosage

Adults

The usual recommended dose is 5 mL (Fexofenadine HCl 30 mg + Pseudoephedrine HCl 60 mg) orally, twice daily, or as directed by a physician.

Elderly

Use with caution. Dosage adjustments may be necessary based on renal function and underlying conditions. Consult a physician.

Renal_impairment

Initial dose should be reduced. Consult a physician for specific dosage recommendations.

How to Take

This suspension is for oral administration. Shake the bottle well before each use. It can be taken with or without food. Do not exceed the recommended dose.

Mechanism of Action

Fexofenadine is a selective peripheral H1-receptor antagonist that inhibits histamine release. Pseudoephedrine is a sympathomimetic amine with direct and indirect effects on adrenergic receptors, producing vasoconstriction and reducing nasal congestion.

Pharmacokinetics

Onset

Within 1 hour for Fexofenadine, 30 minutes for Pseudoephedrine.

Excretion

Fexofenadine is primarily excreted unchanged in bile and urine. Pseudoephedrine is excreted primarily unchanged in urine.

Half life

Fexofenadine: approximately 14 hours. Pseudoephedrine: 4-7 hours.

Absorption

Fexofenadine is rapidly absorbed, Tmax 1-3 hours. Pseudoephedrine is well absorbed, Tmax 1-2 hours for immediate release, extended for ER forms.

Metabolism

Fexofenadine undergoes minimal metabolism. Pseudoephedrine undergoes partial metabolism in the liver.

Side Effects

Contraindications

Hypersensitivity to Fexofenadine, Pseudoephedrine, or any components of the formulation.
Patients with severe hypertension or severe coronary artery disease.
Patients receiving monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing such treatment.
Known history of urinary retention.

Drug Interactions

MAOIs

Concomitant use with MAOIs can lead to a hypertensive crisis.

Beta-blockers

Pseudoephedrine may reduce the antihypertensive effect of beta-blockers.

Erythromycin or Ketoconazole

Can increase plasma levels of Fexofenadine.

Antacids (containing aluminum or magnesium)

Can reduce the absorption of Fexofenadine.

Storage

Store below 30°C in a dry place, away from light. Keep out of reach of children.

Overdose

Symptoms of overdose may include drowsiness, dizziness, dry mouth, nausea, vomiting, epigastric distress, CNS stimulation (insomnia, tremors, seizures). Management is supportive and symptomatic, including gastric lavage or activated charcoal if appropriate.

Pregnancy & Lactation

Pregnancy Category C. Use in pregnancy only if the potential benefit justifies the potential risk to the fetus. Not recommended during breastfeeding as both active ingredients are excreted in breast milk. Consult a physician.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

60 mL bottle

Shelf Life

24 months from manufacturing date.

Availability

Available in pharmacies and hospitals nationwide

Approval Status

Approved by DGDA

Patent Status

Generic available

Clinical Trials

Clinical trials have demonstrated the efficacy and safety of Fexofenadine and Pseudoephedrine in combination for the treatment of seasonal allergic rhinitis. Specific trials for this extended-release suspension formulation would be available from the manufacturer.

Lab Monitoring

No routine lab monitoring is generally required for healthy individuals. Patients with pre-existing conditions (e.g., hypertension, renal impairment) may require monitoring of blood pressure and renal function.

Doctor Notes

Caution in patients with hypertension, cardiovascular disease, diabetes mellitus, glaucoma, prostatic hypertrophy, or hyperthyroidism due to pseudoephedrine component.
Advise patients not to exceed recommended dosage due to potential for CNS stimulation and cardiovascular effects.

Patient Guidelines

Do not exceed the prescribed dose.
Inform your doctor about all other medications you are taking.
Avoid alcohol while taking this medicine.
Report any severe or persistent side effects to your doctor.

Missed Dose Advice

If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose to catch up.