Medicine Information

Brohexin

Name: Brohexin
Brand: Brohexin
Rating: 4.5 (117 reviews)

Syrup4 mg/5 mlMucolytics and Cough PreparationsATC: R05CB02

Generic Name

Bromhexine Hydrochloride

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
brohexin 4 mg syrup	৳ 30.00	N/A

Description

Overview of the medicine

Brohexin 4 mg syrup contains Bromhexine Hydrochloride, a mucolytic agent used to thin and loosen mucus in the airways, making it easier to cough up. It is commonly prescribed for respiratory conditions associated with excessive or thick mucus.

Uses & Indications

Acute and chronic bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.

Bronchitis

Emphysema

Tracheobronchitis

Bronchiectasis

Pneumoconiosis

Cystic fibrosis

Dosage

Adults

8-16 mg (10-20 ml) three times daily.

Elderly

No specific dose adjustment required, but caution is advised in patients with severe hepatic or renal impairment.

Renal_impairment

Reduced dosage or extended intervals may be necessary in severe renal impairment.

How to Take

Oral administration. May be taken with or without food. Use the measuring spoon/cup provided for accurate dosing.

Mechanism of Action

Bromhexine acts by increasing the synthesis of serous bronchial secretion, which helps in reducing the viscosity of mucus. It also activates the ciliary epithelium, aiding in the transport and clearance of mucus from the respiratory tract.

Pharmacokinetics

Onset

Mucolytic effects usually begin within 30 minutes of administration.

Excretion

Excreted primarily via the kidneys (about 85-90%) as metabolites, with a small amount excreted unchanged in urine.

Half life

Approximately 6.5 hours (terminal elimination half-life, with significant first-pass metabolism).

Absorption

Readily and completely absorbed from the gastrointestinal tract.

Metabolism

Extensively metabolized in the liver, primarily by hydroxylation and subsequent glucuronidation. Metabolites include ambroxol.

Side Effects

Contraindications

Hypersensitivity to bromhexine or any component of the formulation.
Patients with peptic ulcer disease (use with caution).

Drug Interactions

Amoxicillin

Bromhexine may increase the penetration of antibiotics (e.g., amoxicillin, erythromycin, oxytetracycline) into bronchial secretions.

Oral anticoagulants

No clinically significant interaction reported, but monitor with caution.

Storage

Store below 30°C in a dry place, away from light. Keep out of reach of children.

Overdose

Symptoms of overdose are generally mild and may include gastrointestinal disturbances. Treatment is symptomatic and supportive. Gastric lavage and activated charcoal may be considered in severe cases.

Pregnancy & Lactation

Pregnancy Category C. Use during pregnancy, especially in the first trimester, should be avoided unless the potential benefits outweigh the risks. Excreted into breast milk; use with caution during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 ml bottle60 ml bottle

Shelf Life

Typically 2-3 years when stored as recommended.

Availability

Pharmacies nationwide

Approval Status

Approved by regulatory authorities

Patent Status

Off-patent

Clinical Trials

Bromhexine has been extensively studied in clinical trials for its efficacy in mucolytic therapy and for its potential anti-inflammatory properties.

Lab Monitoring

No routine lab monitoring is generally required.
Monitor liver and kidney function in patients with pre-existing impairment.

Doctor Notes

Advise patients to stay hydrated to maximize mucolytic effect.
Caution in patients with a history of gastric ulcer.
Inform patients about potential for rare but serious skin reactions and to seek immediate medical attention if they occur.

Patient Guidelines

Do not exceed the recommended dose.
Complete the full course of treatment as prescribed by your doctor.
Drink plenty of fluids to help loosen mucus.
Consult a doctor if symptoms worsen or persist.

Missed Dose Advice

If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

Bromhexine is generally not expected to affect the ability to drive or operate machinery. However, if you experience dizziness or headache, avoid such activities.