Medicine Information

Broklin-CR

Name: Broklin-CR
Brand: Broklin-CR
Rating: 4.5 (117 reviews)

Extended-Release Tablet825 mgFluoroquinolone AntibioticATC: J01MA02

Generic Name

Ciprofloxacin Extended-Release

Manufacturer

Eskayef Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
broklin cr 825 mg tablet	৳ 25.00	৳ 250.00

Description

Overview of the medicine

Broklin-CR 825 mg Tablet is an extended-release fluoroquinolone antibiotic used to treat a variety of bacterial infections, including urinary tract infections, respiratory tract infections, and skin infections. The controlled-release formulation allows for once-daily dosing.

Uses & Indications

Complicated and Uncomplicated Urinary Tract Infections (UTIs)

Chronic Bacterial Prostatitis

Skin and Skin Structure Infections

Bone and Joint Infections

Infectious Diarrhea

Dosage

Adults

For uncomplicated urinary tract infections: 825 mg once daily for 3 days. For complicated urinary tract infections: 825 mg once daily for 7-14 days. For chronic bacterial prostatitis: 825 mg once daily for 28 days.

Elderly

No specific dosage adjustment required for elderly patients unless renal function is significantly impaired.

Renal_impairment

For creatinine clearance (CrCl) < 30 mL/min, the dosage should be reduced. Consult product leaflet for specific guidelines.

How to Take

Take orally, with or without food. Swallow the tablet whole; do not crush, break, or chew it.

Mechanism of Action

Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.

Pharmacokinetics

Onset

Onset of antibacterial action occurs within hours; clinical improvement seen within days.

Excretion

Primarily excreted unchanged by the kidneys (approximately 50-70% via urine) and via feces (approximately 15-30%).

Half life

Elimination half-life is approximately 4-5 hours, but the controlled-release formulation maintains therapeutic concentrations over 24 hours.

Absorption

Well absorbed orally. Peak plasma concentrations are achieved in approximately 6-8 hours for the extended-release formulation. Absolute bioavailability is about 70%.

Metabolism

Partially metabolized in the liver to several less active metabolites (approximately 10-30% of dose).

Side Effects

Contraindications

Hypersensitivity to ciprofloxacin or any other fluoroquinolone
Concomitant administration with tizanidine

Drug Interactions

Warfarin

May enhance the anticoagulant effect of warfarin, requiring INR monitoring.

Tizanidine

Concomitant use is contraindicated due to increased risk of hypotension and sedation.

Theophylline

Increased plasma concentrations of theophylline, leading to potential toxicity.

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

Concurrent use may increase the risk of CNS stimulation and convulsive seizures.

Antacids containing magnesium or aluminum, sucralfate, didanosine (chewable/buffered tablets or pediatric powder), or products containing iron or zinc

Reduced absorption of ciprofloxacin. Administer ciprofloxacin at least 2 hours before or 6 hours after these agents.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

In case of acute overdose, gastric emptying (e.g., induced vomiting or gastric lavage) is recommended. Supportive treatment should be initiated, and the patient should be kept well hydrated. Hemodialysis or peritoneal dialysis does not remove ciprofloxacin significantly.

Pregnancy & Lactation

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Ciprofloxacin is excreted into breast milk and may cause serious adverse reactions in nursing infants; therefore, a decision should be made whether to discontinue nursing or to discontinue the drug.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

7 tablets per pack10 tablets per pack

Shelf Life

24-36 months

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Patent expired (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Ciprofloxacin has undergone extensive clinical trials demonstrating its efficacy and safety across various bacterial infections. Specific trials for extended-release formulations supported once-daily dosing regimens.

Lab Monitoring

Renal function tests (e.g., creatinine, BUN) periodically, especially in patients with impaired renal function
Liver function tests (ALT, AST) if treatment is prolonged or liver impairment is suspected
Prothrombin time/INR for patients on warfarin or other anticoagulants

Doctor Notes

Counsel patients on black box warnings for tendinopathy, peripheral neuropathy, and CNS effects.
Assess renal function before and during therapy, especially in elderly patients.
Avoid co-administration with tizanidine and carefully manage interactions with other drugs like warfarin and theophylline.
Advise patients about photosensitivity and the importance of completing the full course.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor and complete the full course of treatment, even if you feel better.
Do not crush, break, or chew the extended-release tablet; swallow it whole.
Stay well hydrated by drinking plenty of fluids.
Avoid excessive exposure to direct sunlight and use protective clothing/sunscreen due to photosensitivity risk.
Report any pain, swelling, or inflammation of a tendon, or numbness/tingling to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

This medicine may cause dizziness, lightheadedness, or vision changes. Avoid driving or operating machinery until you know how it affects you.

Lifestyle Advice

Maintain good hygiene to prevent recurrence of infections.
Drink adequate water daily unless advised otherwise by your doctor.
Wear sunscreen and protective clothing when outdoors to minimize photosensitivity risk.