Medicine Information

Brolyt

Name: Brolyt
Brand: Brolyt
Rating: 4.5 (117 reviews)

Syrup4 mg/5 mlMucolyticsATC: R05CB02

Generic Name

Bromhexine Hydrochloride

Manufacturer

Acme Laboratories Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
brolyt 4 mg syrup	৳ 40.13	N/A

Description

Overview of the medicine

Bromhexine is a mucolytic agent used to thin and loosen mucus in the airways, making it easier to cough up. It is primarily used for the treatment of respiratory conditions associated with excessive or thick mucus secretion.

Uses & Indications

Productive cough

Acute and chronic bronchitis

Bronchial asthma with difficulty in expectoration

Emphysema

Pneumoconiosis

Bronchiectasis

Inflammatory diseases of the upper respiratory tract

Dosage

Adults

8 mg (10 ml) three times daily. May be increased to 16 mg (20 ml) three times daily in severe cases.

Elderly

No specific dosage adjustment usually required, use adult dose.

Renal_impairment

Caution, dose reduction may be needed in severe renal impairment. Consult a physician.

How to Take

Oral administration. Take with or without food. Use the provided measuring cup for accurate dosing.

Mechanism of Action

Bromhexine depolymerizes mucopolysaccharide fibers directly, reducing mucus viscosity and stimulating serous gland activity, leading to increased and easier expectoration. It also has secretomotor effects, enhancing mucociliary clearance.

Pharmacokinetics

Onset

Effects typically begin within 30 minutes to 1 hour.

Excretion

Primarily excreted via urine, mainly as metabolites.

Half life

Terminal half-life of the active metabolite is approximately 6.5 hours.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract. Undergoes extensive first-pass metabolism.

Metabolism

Extensively metabolized in the liver to various hydroxylated metabolites, including ambroxol, which is also pharmacologically active.

Side Effects

Contraindications

Hypersensitivity to bromhexine or any component of the formulation.
Patients with active peptic ulcer disease (relative contraindication due to potential for gastric irritation).

Drug Interactions

Cough suppressants

Concurrent use should be avoided as it may lead to accumulation of mucus due to impaired cough reflex, increasing the risk of respiratory obstruction.

Antibiotics (e.g., amoxicillin, erythromycin, oxytetracycline)

Bromhexine may increase the penetration of antibiotics into bronchial secretions, potentially enhancing their therapeutic effect.

Storage

Store below 30°C in a dry place. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include nausea, vomiting, diarrhea, epigastric pain, and other gastrointestinal disturbances. Management is symptomatic and supportive. Gastric lavage and activated charcoal may be considered if ingestion is recent.

Pregnancy & Lactation

Use with caution during pregnancy, especially during the first trimester. Consult a physician. Bromhexine passes into breast milk, so caution is advised during lactation. The benefits should outweigh the potential risks.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 ml syrup60 ml syrup

Shelf Life

36 months from manufacturing date.

Availability

Pharmacies, hospitals

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Bromhexine has been extensively studied in clinical trials for its mucolytic efficacy and safety in various respiratory conditions. Information is available in medical literature and regulatory databases.

Lab Monitoring

No routine lab monitoring is generally required for bromhexine.
Monitor for liver function tests in patients with pre-existing hepatic impairment if long-term use is anticipated.

Doctor Notes

Ensure patients understand the difference between productive and non-productive coughs for appropriate use.
Advise patients about maintaining adequate hydration for optimal mucolytic effect.
Counsel on the importance of adhering to prescribed dosage and not exceeding it.
Be vigilant for rare but serious skin reactions (SCARs).

Patient Guidelines

Drink plenty of fluids (water, juice) to help thin mucus and improve expectoration.
Do not use for persistent or chronic cough without consulting a doctor.
Report any severe skin reactions (e.g., rash with fever, blistering) immediately to your doctor.
Avoid concurrent use with cough suppressants.
Complete the full course as prescribed by your doctor, even if symptoms improve.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Brolyt is generally not expected to affect the ability to drive or operate machinery. However, if side effects like dizziness or headache occur, patients should avoid driving or operating heavy machinery.

Lifestyle Advice

Maintain good hydration throughout the day.
Avoid smoking and exposure to secondhand smoke, as it can worsen respiratory conditions.
Ensure adequate rest to aid recovery.
Humidifiers can help moisten air and ease breathing.