Medicine Information

Broxolin

Name: Broxolin
Brand: Broxolin
Rating: 4.5 (117 reviews)

Syrup15 mg/5 mLMucolytic and ExpectorantATC: R05CB06

Generic Name

Ambroxol Hydrochloride

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
broxolin 15 mg syrup	৳ 40.12	N/A

Description

Overview of the medicine

Broxolin 15 mg Syrup contains Ambroxol Hydrochloride, a mucolytic agent used to treat respiratory diseases associated with excessive or viscous mucus. It helps thin and loosen mucus in the airways, making it easier to cough up.

Uses & Indications

Acute and chronic diseases of the respiratory tract associated with abnormal mucus secretion and impaired mucus transport, such as acute and chronic bronchitis, bronchial asthma, bronchiectasis.

Exacerbations of chronic obstructive pulmonary disease (COPD).

Post-operative respiratory complications associated with mucus retention.

Dosage

Adults

10 mL (30 mg) 2-3 times daily, or as directed by physician.

Elderly

No special dosage adjustment is usually required, but caution is advised in patients with severe renal or hepatic impairment.

Renal_impairment

In severe renal impairment, the dosage frequency should be reduced. Consult a physician.

How to Take

Broxolin syrup is for oral administration. It can be taken with or without food. Use a measuring spoon or cup to ensure accurate dosage, especially for children. Drink plenty of fluids to aid the mucolytic action.

Mechanism of Action

Ambroxol acts as a mucolytic by increasing serous mucus secretion in the respiratory tract, reducing the viscosity of sputum, and enhancing mucociliary clearance. It also stimulates the synthesis and release of surfactant by alveolar type II pneumocytes, which helps maintain airway patency.

Pharmacokinetics

Onset

Mucolytic effect typically begins within 30 minutes to 2 hours.

Excretion

Excreted mainly by the kidneys, with approximately 90% eliminated as metabolites and 10% as unchanged drug.

Half life

Plasma half-life is approximately 7-12 hours.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract following oral administration. Peak plasma concentrations are achieved in about 1-2.5 hours.

Metabolism

Primarily metabolized in the liver to various inactive metabolites, mainly by conjugation.

Side Effects

Contraindications

Hypersensitivity to Ambroxol or any other component of the formulation.
Patients with a history of gastric or duodenal ulcers (due to potential for mucosal damage, although rare with Ambroxol).

Drug Interactions

Antibiotics

Concomitant administration of ambroxol with antibiotics (e.g., amoxicillin, cefuroxime, erythromycin, doxycycline) may lead to an increase in the antibiotic concentration in broncho-pulmonary secretions and in sputum.

Storage

Store in a cool, dry place, below 30°C, protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include mild diarrhea and restlessness. Management is primarily supportive and symptomatic. Gastric lavage and induced emesis are not usually recommended. Due to high protein binding and large volume of distribution, forced diuresis and hemodialysis are not effective.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown adverse effects, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy, especially during the first trimester, should only be considered if the potential benefit outweighs the potential risk. Ambroxol is excreted into breast milk; therefore, it is not recommended for use during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

100 ml bottle60 ml bottle

Shelf Life

Usually 2-3 years from the date of manufacture, specific details on packaging.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by DGDA

Patent Status

Off-patent

Clinical Trials

Ambroxol has been widely studied in numerous clinical trials demonstrating its efficacy and safety as a mucolytic agent in various respiratory conditions. Studies support its role in reducing sputum viscosity and improving mucociliary clearance.

Lab Monitoring

Routine lab monitoring is not typically required for Ambroxol.

Doctor Notes

Advise patients to drink plenty of fluids to maximize mucolytic effect.
Caution in patients with a history of gastric ulcers.
Monitor for signs of hypersensitivity reactions, especially skin rashes.

Patient Guidelines

Take the medicine exactly as prescribed by your doctor.
Drink plenty of water or other fluids while taking this medicine to help loosen mucus.
Do not use for prolonged periods without consulting a doctor.
If symptoms persist or worsen, consult your doctor.

Missed Dose Advice

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

Driving Precautions

Broxolin is generally considered safe for driving and operating machinery. However, if you experience dizziness or any other side effect that might impair your ability, avoid these activities.

Lifestyle Advice

Maintain good hydration by drinking adequate fluids.
Avoid smoking and exposure to respiratory irritants, as these can worsen respiratory conditions.
Consider humidifiers to keep the air moist, which can help with mucus clearance.