Medicine Information

Budesonide

Name: Budesonide
Brand: Budesonide
Rating: 4.5 (117 reviews)

Suspension for Nebulization1 mgCorticosteroids; Anti-inflammatory; AntiasthmaticATC: R03BA02

Generic Name

Budesonide 1 mg Suspension for Nebulization

Manufacturer

Generic Pharma Ltd.

Country

Global

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
budetide 1 mg suspension	৳ 70.00	N/A

Description

Overview of the medicine

Budesonide is a synthetic corticosteroid used to reduce inflammation in the airways, typically administered via nebulization for respiratory conditions like asthma and croup.

Uses & Indications

Treatment of asthma in adults and children (as a maintenance therapy)

Treatment of croup (laryngotracheobronchitis) in infants and children

Management of exacerbations of COPD (off-label use, in some cases)

Dosage

Adults

Asthma: 1-2 mg twice daily via nebulizer for severe symptoms, then adjust to the lowest effective dose (e.g., 0.5-1 mg twice daily) for maintenance. Croup: Not typically indicated for adults.

Elderly

No specific dose adjustment required, but use with caution due to potential for comorbidities and polypharmacy.

Renal_impairment

No specific dose adjustment is considered necessary for patients with renal impairment.

How to Take

Administer via a jet nebulizer with a face mask or mouthpiece. Do not use ultrasonic nebulizers. The suspension should not be swallowed. Follow manufacturer's instructions for nebulizer use.

Mechanism of Action

Budesonide works by binding to glucocorticoid receptors in the cytoplasm, forming a complex that translocates to the nucleus and modulates gene expression. This leads to the inhibition of inflammatory mediators (prostaglandins, leukotrienes) and cytokines, reducing inflammation, swelling, and mucus production in the airways.

Pharmacokinetics

Onset

Onset of clinical effect within hours, with maximal therapeutic benefit achieved after several days to weeks of regular use.

Excretion

Excreted primarily in the urine and feces as metabolites.

Half life

Plasma half-life is approximately 2 to 4 hours.

Absorption

Rapidly absorbed from the lungs, with approximately 34% bioavailability due to extensive first-pass hepatic metabolism. Oral bioavailability is low (around 10%).

Metabolism

Extensively metabolized in the liver by CYP3A4 enzymes to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to budesonide or any component of the formulation
Primary treatment of status asthmaticus or other acute episodes of asthma where intensive measures are required

Drug Interactions

Strong CYP3A4 Inhibitors (e.g., Ketoconazole, Itraconazole, Ritonavir, Atazanavir, Clarithromycin)

These drugs can significantly increase systemic exposure to budesonide, potentially leading to corticosteroid side effects. Co-administration should be avoided or used with caution, requiring dose reduction of budesonide and monitoring for systemic effects.

Storage

Store upright at room temperature (below 30°C). Protect from light. Do not freeze. Once the foil pouch is opened, respules should be used within 3 months and protected from light. Once a respule is opened, use immediately.

Overdose

Acute overdose is unlikely to cause clinically significant problems. Chronic overdose may lead to signs and symptoms of hypercorticism, such as Cushing's syndrome, and adrenal suppression. Management includes gradual dose reduction and supportive care.

Pregnancy & Lactation

Pregnancy Category B. Budesonide is generally considered safe for use during pregnancy, and it is the preferred inhaled corticosteroid due to extensive human data. It is excreted in breast milk in small amounts; use with caution during lactation, benefits should outweigh risks.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

5 respules per pack10 respules per pack20 respules per pack

Shelf Life

Typically 2-3 years, check specific product packaging for exact expiry date.

Availability

Available in pharmacies and hospitals

Approval Status

Globally Approved (e.g., FDA, EMA, DGDA)

Patent Status

Patent Expired (Generics Available)

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety of budesonide in the treatment of asthma, croup, and other inflammatory respiratory conditions in both adults and children.

Lab Monitoring

Monitor growth rate in children and adolescents receiving long-term treatment.
Consider bone mineral density monitoring in patients at risk for osteoporosis.
Periodically assess adrenal function, especially in patients transitioning from systemic corticosteroids or on high doses.

Doctor Notes

Emphasize proper nebulization technique to ensure optimal drug delivery.
Advise patients that budesonide is a controller medication and should not be used for acute bronchospasm relief.
Monitor children for potential growth suppression with long-term use.
Educate patients on the importance of oral hygiene to prevent candidiasis.

Patient Guidelines

Rinse mouth with water and spit out after each nebulization to minimize the risk of oral candidiasis.
Use a spacer device if recommended by your doctor to improve drug delivery.
Do not use this medicine for sudden breathing problems; it is for maintenance therapy.
Ensure proper cleaning and maintenance of the nebulizer device.