Budison-F
Generic Name
Budesonide & Formoterol Fumarate Dihydrate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| budison f 80 mcg inhaler | ৳ 400.00 | N/A |
Description
Overview of the medicine
Budison-F 80 mcg Inhaler is a combination medicine containing Budesonide, a corticosteroid, and Formoterol, a long-acting beta2-agonist. It is used to relieve symptoms of asthma and chronic obstructive pulmonary disease (COPD) by reducing inflammation and relaxing the muscles of the airways.
Uses & Indications
Dosage
Adults
Asthma: 1-2 inhalations twice daily. COPD: 2 inhalations twice daily. Always consult a physician.
Elderly
No specific dose adjustment is generally required, but caution is advised in patients with co-morbidities. Always consult a physician.
Renal_impairment
No specific dose adjustment is required for renal impairment, but caution is advised. Always consult a physician.
How to Take
For inhalation use only. Follow the instructions provided with the inhaler device carefully. Rinse mouth with water after each use to reduce the risk of oral thrush.
Mechanism of Action
Budesonide is a potent glucocorticoid with anti-inflammatory activity. It reduces inflammation in the airways, decreasing mucus production and airway hyperresponsiveness. Formoterol is a highly potent and selective long-acting beta2-adrenergic agonist that relaxes the smooth muscles of the bronchi, leading to bronchodilation and improved airflow.
Pharmacokinetics
Onset
Formoterol: 1-3 minutes; Budesonide: hours to days for full anti-inflammatory effect.
Excretion
Primarily renal (urine) for both, some fecal.
Half life
Budesonide: 2-3 hours; Formoterol: 8-10 hours.
Absorption
Budesonide has moderate systemic bioavailability (around 10-20% after inhalation); Formoterol is rapidly absorbed (systemic bioavailability ~10%).
Metabolism
Both extensively metabolized in the liver via CYP3A4.
Side Effects
Contraindications
- Hypersensitivity to budesonide, formoterol, or any excipients
- Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required
Drug Interactions
Diuretics (e.g., Furosemide)
May potentiate hypokalemia associated with beta2-agonists.
Tricyclic antidepressants, MAO inhibitors
Can potentiate the cardiovascular effects of Formoterol.
Beta-adrenergic blockers (e.g., Propranolol)
Can reduce the effect of Formoterol and may cause severe bronchospasm in asthma patients.
CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir)
Can increase systemic exposure to Budesonide, leading to potential corticosteroid side effects.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose may lead to exaggerated common side effects such as tremor, palpitations, headache (due to Formoterol) and systemic corticosteroid effects like adrenal suppression (due to Budesonide). Treatment is symptomatic and supportive, including monitoring of vital signs and electrolytes.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Both budesonide and formoterol are excreted in breast milk; use with caution during lactation and only if clearly needed.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA, EMA, FDA for similar combinations)
Patent Status
Generic available, original patent expired for combination
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have demonstrated the efficacy and safety of budesonide/formoterol combination in the treatment of asthma and COPD across various patient populations and severities. Studies support its use for both maintenance and as-needed therapy in some asthma regimens.
Lab Monitoring
- Monitor for signs of adrenal insufficiency, especially during withdrawal or stress
- Monitor serum potassium levels in patients at risk of hypokalemia
Doctor Notes
- Emphasize proper inhaler technique and mouth rinsing to minimize local side effects.
- Educate patients that this is a controller medication and not a reliever for acute symptoms.
- Monitor for signs of systemic corticosteroid effects with long-term use, especially in vulnerable populations.
Patient Guidelines
- Always use your inhaler as directed by your doctor.
- Rinse your mouth with water after each dose to prevent oral thrush.
- This medicine is for maintenance treatment and not for acute asthma attacks or acute bronchospasm.
- Do not stop using this medicine suddenly without consulting your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time. Do not double the dose.
Driving Precautions
Generally safe to drive, but if you experience dizziness or tremor, avoid driving or operating machinery until symptoms subside.
Lifestyle Advice
- Avoid known asthma or COPD triggers (e.g., smoke, allergens).
- Maintain a healthy lifestyle, including regular exercise and a balanced diet.
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Global Brand Names
International brand names for this medicine
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