Medicine Information

Buflex

Name: Buflex
Brand: Buflex
Rating: 4.5 (117 reviews)

Tablet750 mgNon-steroidal Anti-inflammatory Drugs (NSAIDs)ATC: M01AE02

Generic Name

buflex-750-mg-tablet

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
buflex 750 mg tablet	৳ 22.00	৳ 220.00

Description

Overview of the medicine

Buflex 750 mg tablet contains Naproxen, a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, inflammation, and stiffness caused by various conditions like arthritis, muscle aches, and menstrual cramps.

Uses & Indications

Rheumatoid arthritis

Osteoarthritis

Ankylosing spondylitis

Juvenile idiopathic arthritis

Tendinitis

Bursitis

Acute gout

Dysmenorrhea

Acute pain (e.g., musculoskeletal trauma)

Dosage

Adults

For chronic conditions: 500-1000 mg daily in one or two doses. For acute conditions (e.g., acute gout): 750 mg initially, then 250 mg every 8 hours until attack subsides. Max 1250 mg on the first day.

Elderly

Use with caution; consider lower doses due to increased risk of side effects, especially GI bleeding and renal impairment.

Renal_impairment

Use with caution; dose reduction may be necessary, and close monitoring of renal function is advised. Avoid in severe renal impairment.

How to Take

Take with food or milk to reduce gastrointestinal upset. Swallow the tablet whole with a full glass of water. Do not crush or chew.

Mechanism of Action

Naproxen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins, mediators of pain and inflammation.

Pharmacokinetics

Onset

1-2 hours for pain relief, longer for chronic inflammatory conditions.

Excretion

Mainly excreted in the urine (about 95%) as metabolites and conjugates, with a small amount in feces.

Half life

Approximately 12-17 hours.

Absorption

Rapidly and completely absorbed from the gastrointestinal tract.

Metabolism

Primarily metabolized in the liver by demethylation and glucuronidation.

Side Effects

Contraindications

Known hypersensitivity to naproxen or other NSAIDs (e.g., aspirin-induced asthma)
Active gastrointestinal bleeding or peptic ulcer
Severe heart failure
Severe renal impairment
Severe hepatic impairment
Third trimester of pregnancy
Coronary artery bypass graft (CABG) surgery (peri-operative pain)

Drug Interactions

Lithium

Increased lithium plasma levels and toxicity.

Methotrexate

Increased methotrexate toxicity.

ACE inhibitors/ARBs

Reduced antihypertensive effect; increased risk of renal impairment.

Other NSAIDs/Aspirin

Increased risk of GI side effects and bleeding.

Diuretics (e.g., Furosemide)

Reduced diuretic and antihypertensive effects; increased risk of renal impairment.

Anticoagulants (e.g., Warfarin)

Increased risk of bleeding.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms may include drowsiness, heartburn, nausea, vomiting, epigastric pain. More severe cases may involve gastrointestinal bleeding, hypertension, acute renal failure, respiratory depression, and coma. Treatment is symptomatic and supportive; gastric lavage, activated charcoal, and monitoring of vital signs may be required.

Pregnancy & Lactation

Pregnancy: Avoid in the third trimester due to potential premature closure of ductus arteriosus and fetal renal dysfunction. Use in first two trimesters only if clearly needed and benefits outweigh risks. Lactation: Naproxen passes into breast milk in small amounts; use with caution or consider an alternative, especially with long-term use.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box

Shelf Life

Typically 2-3 years from the date of manufacture.

Availability

Pharmacies, Hospitals

Approval Status

Approved by major regulatory bodies (e.g., FDA, DGDA)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied in numerous clinical trials demonstrating efficacy in pain and inflammation management. Ongoing post-marketing surveillance.

Lab Monitoring

Complete Blood Count (CBC) periodically, especially with long-term use, to monitor for anemia.
Renal function (BUN, creatinine) periodically, especially in elderly or patients with pre-existing renal impairment.
Liver function tests (ALT, AST) periodically, especially with long-term use.
Blood pressure monitoring.

Doctor Notes

Counsel patients on potential GI and CV risks, especially for long-term therapy.
Consider prescribing a proton pump inhibitor (PPI) with naproxen for high-risk patients (e.g., history of GI bleed, elderly).
Monitor renal function and blood pressure regularly.

Patient Guidelines

Take with food or milk to minimize stomach upset.
Do not exceed the prescribed dose or duration of treatment.
Report any signs of unusual bleeding, dark stools, or severe abdominal pain immediately.
Avoid alcohol while taking this medicine.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.