Medicine Information

Caboxen

Name: Caboxen
Brand: Caboxen
Rating: 4.5 (117 reviews)

Capsule20 mgProton Pump Inhibitor (PPI)ATC: A02BC01

Generic Name

Omeprazole

Manufacturer

Reputable Pharma Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
caboxen 20 mg capsule	৳ 355.00	N/A

Description

Overview of the medicine

Caboxen 20 mg Capsule contains Omeprazole, a proton pump inhibitor used to reduce stomach acid production. It is prescribed for conditions like heartburn, acid reflux, stomach ulcers, and other acidity-related issues.

Uses & Indications

Gastroesophageal Reflux Disease (GERD)

Duodenal and Gastric Ulcers

Erosive Esophagitis

Zollinger-Ellison Syndrome

Maintenance of healing of erosive esophagitis

Dosage

Adults

For GERD: 20 mg once daily for 4-8 weeks. For Duodenal Ulcer: 20 mg once daily for 2-4 weeks. For Gastric Ulcer: 20 mg once daily for 4-8 weeks. Zollinger-Ellison Syndrome: Initial dose 60 mg once daily, adjusted as needed.

Elderly

No dosage adjustment is generally needed for the elderly with normal renal and hepatic function.

Renal_impairment

No dosage adjustment is generally needed for patients with renal impairment.

How to Take

Take Caboxen 20 mg Capsule orally, preferably in the morning before a meal. Swallow the capsule whole with water; do not chew or crush it. If swallowing is difficult, the capsule may be opened and the pellets mixed with a small amount of fruit juice or applesauce.

Mechanism of Action

Omeprazole inhibits the H+/K+-ATPase (proton pump) in gastric parietal cells, thereby blocking the final step of acid production. This leads to a dose-dependent inhibition of both basal and stimulated acid secretion.

Pharmacokinetics

Onset

Within 1 hour

Excretion

Mainly excreted in urine as metabolites (approx. 77%) and in feces (approx. 18%).

Half life

0.5 to 1 hour (plasma), but effects on acid suppression are much longer due to irreversible binding to the proton pump.

Absorption

Rapidly absorbed from the gastrointestinal tract, primarily in the small intestine. Bioavailability is about 30-40% after a single dose, increasing to about 60% with repeated dosing.

Metabolism

Extensively metabolized in the liver by the cytochrome P450 system (primarily CYP2C19 and CYP3A4).

Side Effects

Contraindications

Hypersensitivity to Omeprazole or any component of the formulation.
Concomitant use with Nelfinavir.

Drug Interactions

Warfarin

Increased INR and prothrombin time. Monitor frequently.

Tacrolimus

Increased tacrolimus levels. Monitor drug levels.

Clopidogrel

Omeprazole may reduce the antiplatelet effect of Clopidogrel. Avoid concomitant use.

Methotrexate

Increased methotrexate levels. Consider temporary withdrawal of omeprazole.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include drowsiness, confusion, blurred vision, tachycardia, nausea, sweating, headache, dry mouth. Treatment is symptomatic and supportive. There is no specific antidote.

Pregnancy & Lactation

Pregnancy Category C. Use only if clearly needed. Excreted in breast milk, caution is advised in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules30 capsules

Shelf Life

24 months

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Omeprazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety in various acid-related disorders. Post-marketing surveillance continues to monitor its long-term effects.

Lab Monitoring

Periodic monitoring of liver function tests may be considered in patients with severe hepatic impairment.
Serum magnesium levels should be monitored in patients on long-term therapy, especially with diuretics.

Doctor Notes

Consider lowest effective dose for shortest duration for GERD.
Review need for long-term PPI therapy regularly.
Be aware of potential drug interactions, especially with Clopidogrel.

Patient Guidelines

Take the medicine as directed by your doctor.
Do not stop taking the medicine suddenly without consulting your doctor.
Inform your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Caboxen may cause dizziness or visual disturbances in some patients. If you experience these symptoms, avoid driving or operating machinery.

Lifestyle Advice

Avoid foods and drinks that trigger heartburn (e.g., spicy foods, caffeine, alcohol).
Eat smaller, more frequent meals.
Elevate the head of your bed to reduce nighttime reflux.