Medicine Information

Cal-D-Zen

Name: Cal-D-Zen
Brand: Cal-D-Zen
Rating: 4.5 (117 reviews)

TabletElemental Calcium 500 mg & Vitamin D3 400 IUSpecific mineral & vitamin preparationsATC: A12AX

Generic Name

Calcium Carbonate (equivalent to Elemental Calcium 500 mg) + Vitamin D3

Manufacturer

Beximco Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cal d zen 500 mg tablet	৳ 5.75	N/A

Description

Overview of the medicine

Cal-D-Zen 500 mg Tablet is a combination of Calcium Carbonate and Vitamin D3 used for the prevention and treatment of calcium and vitamin D deficiencies, and to support bone health.

Uses & Indications

Treatment and prevention of calcium and Vitamin D deficiency

Osteoporosis (adjunctive therapy)

Osteomalacia

Rickets

Increased calcium requirements (e.g., during pregnancy, lactation, rapid growth)

Dosage

Adults

Usually 1-2 tablets daily, or as directed by physician.

Elderly

Similar to adult dosage, but caution with renal impairment.

Renal_impairment

Use with caution and dose adjustment may be necessary based on serum calcium levels; contraindicated in severe renal failure.

How to Take

Tablets can be taken with or without food, preferably with meals to enhance absorption and minimize gastrointestinal upset. Do not chew or crush.

Mechanism of Action

Calcium is essential for bone formation, muscle contraction, and nerve function. Vitamin D3 helps in the absorption of calcium from the gut and its deposition into bones.

Pharmacokinetics

Onset

Gradual, effects on bone density are observed over weeks to months.

Excretion

Calcium is excreted primarily via feces and urine. Vitamin D3 metabolites are excreted mainly in bile and feces, with some renal excretion.

Half life

Elemental Calcium has no specific half-life; Vitamin D3's active metabolite (calcitriol) has a half-life of 3-6 hours.

Absorption

Calcium absorption varies (20-40%) and is enhanced by Vitamin D. Vitamin D3 is well-absorbed from the gut.

Metabolism

Calcium is not metabolized; Vitamin D3 is metabolized in the liver to 25-hydroxyvitamin D and then in the kidneys to 1,25-dihydroxyvitamin D (calcitriol).

Side Effects

Contraindications

Hypercalcaemia (high calcium levels in blood)
Hypercalciuria (high calcium levels in urine)
Severe renal impairment
Kidney stones (nephrolithiasis)
Hypersensitivity to any component

Drug Interactions

Levothyroxine

Reduced absorption; separate administration by at least 4 hours.

Bisphosphonates

Reduced absorption; separate administration by at least 30 minutes.

Thiazide diuretics

May increase risk of hypercalcaemia.

Tetracyclines & Quinolones

Calcium can reduce their absorption; take at least 2 hours before or 4-6 hours after calcium.

Storage

Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms include nausea, vomiting, constipation, thirst, polyuria, muscle weakness, and confusion. In severe cases, hypercalcaemic crisis may occur. Treatment involves discontinuation of the supplement, hydration, and medical management of hypercalcaemia.

Pregnancy & Lactation

Generally considered safe and often recommended during pregnancy and lactation to meet increased calcium and vitamin D requirements, but should be taken under medical supervision.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per strip30 tablets per box60 tablets per box

Shelf Life

24 months

Availability

Pharmacies, drugstores

Approval Status

Approved by DGDA

Patent Status

Generic available

Clinical Trials

Extensive clinical data supports the efficacy of calcium and vitamin D supplementation for bone health and deficiency treatment.

Lab Monitoring

Serum calcium levels (especially in patients with renal impairment or on long-term therapy)
Serum phosphate levels
Renal function tests

Doctor Notes

Advise patients on dietary sources of calcium and vitamin D.
Monitor serum calcium and renal function, especially in elderly or renally impaired patients.
Counsel patients on potential drug interactions.

Patient Guidelines

Do not exceed the recommended dose.
Inform your doctor about all other medications you are taking.
Maintain adequate fluid intake.
Report any unusual symptoms to your doctor.

Missed Dose Advice

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.