Medicine Information

Cantina

Name: Cantina
Brand: Cantina
Rating: 4.5 (117 reviews)

Topical Cream1% w/wAntifungalATC: D01AC01

Generic Name

Clotrimazole 1% Topical Cream

Manufacturer

Hypothetical Pharma

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cantina 1 cream	৳ 35.11	N/A

Description

Overview of the medicine

Cantina-1-cream is an antifungal medication containing Clotrimazole 1%. It is used to treat a variety of fungal skin infections, including athlete's foot, jock itch, ringworm, and other superficial fungal infections caused by dermatophytes and yeasts.

Uses & Indications

Tinea pedis (athlete's foot)

Tinea cruris (jock itch)

Tinea corporis (ringworm)

Cutaneous candidiasis

Pityriasis versicolor

Dosage

Adults

Apply a thin layer of cream to the affected skin area and surrounding skin, gently rubbing it in, 2 to 3 times daily. Continue treatment for 2-4 weeks, even if symptoms improve.

Elderly

No specific dosage adjustment is required for elderly patients.

Renal_impairment

No dosage adjustment is necessary for patients with renal impairment, as systemic absorption is minimal.

How to Take

For external use only. Wash the affected area and dry thoroughly before applying the cream. Wash hands before and after applying the cream to prevent spreading the infection.

Mechanism of Action

Clotrimazole works by inhibiting the biosynthesis of ergosterol, an essential component of the fungal cell membrane. This disruption leads to increased permeability of the fungal cell membrane, resulting in leakage of cellular contents and ultimately cell death.

Pharmacokinetics

Onset

Symptomatic relief typically begins within a few days of starting treatment, with full resolution taking 2-4 weeks.

Excretion

Metabolites are excreted in urine and feces.

Half life

Not well-defined for topical application due to minimal systemic absorption; estimated to be short if any systemic absorption occurs.

Absorption

Minimal systemic absorption occurs after topical application of clotrimazole cream. Less than 0.5% of the applied dose is absorbed, leading to very low plasma concentrations.

Metabolism

Absorbed clotrimazole is rapidly metabolized in the liver to inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to clotrimazole or any other components of the cream.

Drug Interactions

Tacrolimus (systemic)

Although systemic absorption is minimal, theoretically, high dose topical clotrimazole might affect the metabolism of drugs metabolized by CYP3A4, like systemic tacrolimus, but clinical significance is generally negligible for topical use.

Storage

Store below 30°C in a dry place, away from direct sunlight and moisture. Do not freeze. Keep out of reach of children.

Overdose

Topical overdose is unlikely to cause systemic effects due to minimal absorption. If excessive amounts are applied, wipe off the excess and wash the area. In case of accidental ingestion, seek medical attention immediately.

Pregnancy & Lactation

Pregnancy Category B. Clotrimazole is generally considered safe for topical use during pregnancy and lactation. However, consult your doctor before use.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 g cream20 g cream

Shelf Life

36 months (3 years)

Availability

Pharmacies, drugstores

Approval Status

Approved by regulatory authorities

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Clotrimazole has been extensively studied in numerous clinical trials demonstrating its efficacy and safety for the treatment of various superficial fungal infections. Studies consistently show high cure rates and good tolerability.

Lab Monitoring

Not typically required for topical clotrimazole treatment.

Doctor Notes

Confirm fungal diagnosis before prescribing.
Emphasize completing the full course of treatment to prevent relapse.
Advise patients on proper hygiene practices.

Patient Guidelines

Use the cream for the full prescribed duration, even if symptoms improve.
Do not cover the treated area with bandages or tight clothing unless directed by your doctor.
Avoid contact with eyes, mouth, and other mucous membranes.
Do not share this medicine with others.

Missed Dose Advice

If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.