Medicine Information

Cefim-3-DS

Name: Cefim-3-DS
Brand: Cefim-3-DS
Rating: 4.5 (117 reviews)

Capsule400 mgAntibiotics, CephalosporinsATC: J01DD08

Generic Name

Cefixime

Manufacturer

Beximco Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cefim 3 ds 400 mg capsule	৳ 60.00	৳ 180.00

Description

Overview of the medicine

Cefixime is an oral third-generation cephalosporin antibiotic used to treat various bacterial infections.

Uses & Indications

Uncomplicated Urinary Tract Infections (UTIs)

Otitis Media (middle ear infection)

Pharyngitis and Tonsillitis (throat and tonsil infections)

Acute Bronchitis and Acute Exacerbations of Chronic Bronchitis

Uncomplicated Gonorrhea (cervical/urethral)

Dosage

Adults

400 mg once daily or 200 mg every 12 hours. Duration typically 7-14 days depending on the infection. For uncomplicated gonorrhea, a single 400 mg dose.

Elderly

No specific dose adjustment is generally required unless there is severe renal impairment. Monitor renal function.

Renal_impairment

For creatinine clearance 21-60 mL/min, the dose should be reduced to 200 mg daily. For creatinine clearance < 20 mL/min, the dose should be reduced to 100 mg daily.

How to Take

Cefim-3-DS 400 mg capsule can be taken orally with or without food. Taking it with food may help reduce gastrointestinal upset.

Mechanism of Action

Cefixime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located inside the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death.

Pharmacokinetics

Onset

1-4 hours

Excretion

Primarily renal excretion (approximately 50% of an absorbed dose is excreted unchanged in the urine over 24 hours). Some biliary excretion also occurs.

Half life

3-4 hours

Absorption

Approximately 40-50% orally absorbed. Peak plasma concentrations are reached 2-6 hours after administration. Food may delay absorption but does not significantly affect the total amount absorbed.

Metabolism

Minimal hepatic metabolism. No active metabolites identified.

Side Effects

Contraindications

Known hypersensitivity to cefixime or any other cephalosporin antibiotics.
History of severe hypersensitivity reactions (e.g., anaphylaxis) to penicillin or other beta-lactam antibiotics.

Drug Interactions

Probenecid

Increases cefixime plasma concentrations and extends its half-life by inhibiting renal excretion.

Carbamazepine

Cefixime may increase carbamazepine levels when co-administered. Monitor carbamazepine levels.

Warfarin and other anticoagulants

May increase prothrombin time (INR) and the risk of bleeding. Close monitoring of coagulation parameters is recommended.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, gastric lavage may be indicated. Cefixime is not removed in significant quantities by hemodialysis or peritoneal dialysis. Treatment should be symptomatic and supportive.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have not shown harm to the fetus, but there are no adequate and well-controlled studies in pregnant women. Use only if clearly needed. Small amounts of cefixime are excreted in breast milk; use with caution during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

Box containing 1 x 6 capsules in blister packBox containing 1 x 10 capsules in blister pack

Shelf Life

24 months from the date of manufacture

Availability

Pharmacies, hospitals

Approval Status

Approved by regulatory bodies (e.g., FDA, DGDA)

Patent Status

Off-patent (generic available)

WHO Essential Medicine

Yes

Clinical Trials

Cefixime has been extensively studied in various clinical trials demonstrating its efficacy and safety across a range of bacterial infections. Ongoing research continues to monitor resistance patterns and optimize treatment protocols.

Lab Monitoring

Renal function in patients with pre-existing renal impairment (creatinine clearance).
Prothrombin time/INR in patients concurrently receiving anticoagulants.

Doctor Notes

Emphasize the importance of completing the full course of Cefixime to prevent antibiotic resistance and ensure eradication of infection.
Advise patients to report severe or persistent diarrhea promptly due to the risk of Clostridium difficile-associated diarrhea.

Patient Guidelines

Complete the full course of medication even if symptoms improve to prevent recurrence and development of antibiotic resistance.
Do not share this medication with others.
Report any severe or persistent diarrhea to your doctor, as it could be a sign of a more serious condition (e.g., Clostridium difficile-associated diarrhea).

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Cefixime generally does not impair the ability to drive or operate machinery. However, if you experience side effects like dizziness, avoid driving or performing tasks requiring alertness.