Medicine Information

Cefoxguard

Name: Cefoxguard
Brand: Cefoxguard
Rating: 4.5 (117 reviews)

Injection (Powder for solution)500 mgAntibiotics (2nd Gen Cephalosporins)ATC: J01DA05

Generic Name

Cefoxitin Sodium

Manufacturer

The Acme Laboratories Ltd.

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cefoxguard 500 mg injection	৳ 120.00	N/A

Description

Overview of the medicine

Cefoxguard 500 mg Injection contains Cefoxitin, a second-generation cephalosporin antibiotic. It is used to treat a wide range of bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, bone and joint infections, and gynecological infections. It is effective against both Gram-positive and Gram-negative bacteria, including some anaerobic bacteria.

Uses & Indications

Treatment of respiratory tract infections

Treatment of urinary tract infections

Treatment of skin and soft tissue infections

Treatment of bone and joint infections

Treatment of gynecological infections (e.g., pelvic inflammatory disease)

Treatment of intra-abdominal infections (e.g., peritonitis)

Surgical prophylaxis

Dosage

Adults

Usual adult dosage: 1-2 grams intravenously (IV) or intramuscularly (IM) every 6-8 hours. For moderate to severe infections, up to 12 grams/day in divided doses. For uncomplicated gonorrhea, 2 grams IM as a single dose with 1 gram oral probenecid.

Elderly

Dosage adjustment may be necessary in elderly patients with impaired renal function. Monitor renal function closely.

Renal_impairment

Dosage should be adjusted based on creatinine clearance. For CrCl 30-50 mL/min, 1-2 g every 8-12 hours. For CrCl 10-29 mL/min, 1-2 g every 12-24 hours. For CrCl <10 mL/min, 0.5-1 g every 24-48 hours. Hemodialysis patients require a supplementary dose after dialysis.

How to Take

Cefoxguard 500 mg Injection is administered intravenously (IV) or intramuscularly (IM). For IV administration, reconstitute the powder with sterile water for injection, and further dilute if needed for infusion. For IM administration, reconstitute with sterile water for injection or 0.5% lidocaine HCl solution.

Mechanism of Action

Cefoxitin acts by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) located in the bacterial cell wall, which prevents the cross-linking of peptidoglycan chains, leading to cell lysis and bacterial death. It is resistant to many beta-lactamases produced by both aerobic and anaerobic bacteria.

Pharmacokinetics

Onset

Rapid, within minutes for IV administration and 20-30 minutes for IM administration.

Excretion

Approximately 85% of an administered dose is excreted unchanged in the urine within 6 hours by glomerular filtration and tubular secretion.

Half life

Approximately 41-59 minutes in adults with normal renal function, significantly prolonged in renal impairment.

Absorption

Cefoxitin is rapidly absorbed after intramuscular (IM) injection, reaching peak plasma concentrations within 20 to 30 minutes. Intravenous (IV) administration provides immediate and complete systemic availability.

Metabolism

Cefoxitin is minimally metabolized in the liver; primarily excreted unchanged.

Side Effects

Contraindications

Known hypersensitivity to cefoxitin or any other cephalosporin antibiotics
History of severe hypersensitivity reaction to penicillin (due to potential cross-reactivity)

Drug Interactions

Probenecid

Increases and prolongs cefoxitin plasma concentrations by decreasing renal tubular secretion.

Aminoglycosides

Concurrent use may increase the risk of nephrotoxicity.

Oral Anticoagulants

May enhance the anticoagulant effect by altering gut flora; monitor INR/PT.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. Reconstituted solution should be used immediately or stored as per specific instructions (e.g., refrigerated for a short period).

Overdose

Symptoms of overdose may include neurological effects such as seizures, especially in patients with renal impairment. Treatment is symptomatic and supportive. Hemodialysis may be useful to remove the drug from the blood.

Pregnancy & Lactation

Pregnancy Category B. Studies in animals have shown no evidence of harm to the fetus, but adequate and well-controlled studies in pregnant women are lacking. Use during pregnancy only if clearly needed. Cefoxitin is excreted in breast milk in small amounts; use caution when administered to a nursing mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1 vial per pack

Shelf Life

2-3 years from manufacturing date when stored correctly.

Availability

Hospitals, retail pharmacies

Approval Status

Approved

Patent Status

Off-patent

Clinical Trials

Extensive clinical trials have established cefoxitin's efficacy and safety in various bacterial infections and surgical prophylaxis. Ongoing surveillance helps monitor emerging resistance patterns.

Lab Monitoring

Monitor renal function (creatinine, BUN) periodically, especially in patients with pre-existing renal impairment or during prolonged therapy.
Monitor liver function tests (ALT, AST) periodically.
Periodic blood counts (CBC) may be advisable during prolonged therapy.

Doctor Notes

Cross-allergenicity with penicillin is approximately 5-10%; use with caution in penicillin-allergic patients.
Adjust dose in renal impairment.
Monitor for pseudomembranous colitis, which can occur during or after treatment.
Not effective against MRSA.

Patient Guidelines

Complete the full course of treatment as prescribed by your doctor, even if you start to feel better.
Report any severe or persistent side effects to your doctor immediately.
Do not share this medicine with others.
Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Generally considered safe to drive or operate machinery, but be aware of potential rare side effects like dizziness or seizures, especially with very high doses or in patients with renal impairment. If you experience such effects, avoid driving.