Medicine Information

Cibact

Name: Cibact
Brand: Cibact
Rating: 4.5 (117 reviews)

Tablet500 mgFluoroquinolone antibioticsATC: J01MA02

Generic Name

Ciprofloxacin 500 mg tablet

Manufacturer

Acme Laboratories Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cibact 500 mg tablet	৳ 15.00	৳ 150.00

Description

Overview of the medicine

Ciprofloxacin is a broad-spectrum antibiotic from the fluoroquinolone class. It is used to treat a wide range of bacterial infections including urinary tract infections, respiratory tract infections, skin and soft tissue infections, bone and joint infections, and certain gastrointestinal infections.

Uses & Indications

Urinary tract infections (UTIs)

Respiratory tract infections (e.g., exacerbations of chronic bronchitis, pneumonia)

Skin and soft tissue infections

Bone and joint infections

Gastrointestinal infections (e.g., bacterial diarrhea)

Sexually transmitted infections (e.g., gonorrhea)

Dosage

Adults

The usual adult oral dose is 250 mg to 750 mg twice daily, depending on the severity and type of infection. For most moderate infections, 500 mg twice daily is common. Duration varies from 7 to 14 days.

Elderly

No specific dose adjustment is needed based on age alone, but renal function should be assessed, and dosage adjusted accordingly if renal impairment is present.

Renal_impairment

Dosage adjustment is necessary for patients with impaired renal function (creatinine clearance < 30 mL/min). A common recommendation is half the usual dose or extending the dosing interval.

How to Take

Take the tablet orally with a glass of water, with or without food. Do not take with dairy products (milk, yogurt) or calcium-fortified juices alone. Avoid taking antacids, sucralfate, or iron/zinc supplements within 2 hours of taking Ciprofloxacin.

Mechanism of Action

Ciprofloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication, transcription, repair, and recombination. This leads to disruption of bacterial DNA and cell death.

Pharmacokinetics

Onset

Therapeutic effects typically begin within 1-2 hours after administration.

Excretion

Primarily excreted via the kidneys (approximately 50-70% as unchanged drug) and to a lesser extent via feces (approximately 15% as unchanged drug).

Half life

Plasma elimination half-life is typically 3-5 hours.

Absorption

Rapidly and well-absorbed from the gastrointestinal tract after oral administration. Bioavailability is approximately 70-80%. Peak plasma concentrations are reached within 1-2 hours.

Metabolism

Approximately 15-30% of Ciprofloxacin is metabolized in the liver to several less active metabolites, primarily via CYP1A2.

Side Effects

Contraindications

Hypersensitivity to Ciprofloxacin or other fluoroquinolones
Concomitant use with Tizanidine (due to risk of severe hypotension and somnolence)
History of tendon disorders related to quinolone use

Drug Interactions

Warfarin

May enhance the anticoagulant effect of warfarin, increasing bleeding risk. Monitor INR/PT.

Tizanidine

Contraindicated due to significant increase in Tizanidine exposure, leading to hypotension and somnolence.

Cyclosporine

May increase serum creatinine levels. Monitor renal function.

Theophylline

Ciprofloxacin can increase theophylline plasma levels, leading to increased risk of toxicity. Monitor theophylline levels.

NSAIDs (Nonsteroidal Anti-inflammatory Drugs)

Concurrent use may increase the risk of CNS stimulation and convulsive seizures.

Antacids (containing aluminum/magnesium), Sucralfate, Didanosine, Iron/Zinc salts

Can significantly reduce Ciprofloxacin absorption. Administer Ciprofloxacin at least 2 hours before or 6 hours after these agents.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

In the event of an acute overdose, gastric emptying (e.g., gastric lavage, induced emesis) may be considered. Maintain adequate hydration. Symptomatic and supportive care should be instituted. Ciprofloxacin is not effectively removed by hemodialysis or peritoneal dialysis.

Pregnancy & Lactation

Pregnancy Category C. Ciprofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in human milk and may cause adverse effects in a nursing infant. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

1x10 tablets (blister pack)

Shelf Life

Typically 24 to 36 months from the date of manufacture.

Availability

Available in pharmacies and hospitals

Approval Status

Approved by regulatory authorities (e.g., DGDA, FDA)

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

Ciprofloxacin has undergone extensive clinical trials since its development, establishing its efficacy and safety for various bacterial infections. Ongoing research continues to explore its use in new indications and resistance patterns.

Lab Monitoring

Renal function (creatinine, BUN) in patients with pre-existing renal impairment.
Liver function tests (ALT, AST, ALP) if treatment is prolonged or if symptoms of hepatotoxicity occur.
Blood counts (CBC) if clinically indicated or for long-term therapy.
INR/PT if co-administered with warfarin.

Doctor Notes

Ensure proper diagnosis of bacterial infection before prescribing, as Ciprofloxacin is ineffective against viral infections.
Counsel patients on the importance of completing the full course of therapy to prevent resistance.
Advise patients about potential serious adverse effects such as tendinopathy and peripheral neuropathy, and to seek immediate medical attention if symptoms occur.
Caution with concomitant use of drugs that prolong the QT interval.

Patient Guidelines

Complete the entire course of medication even if symptoms improve to prevent antibiotic resistance.
Stay well-hydrated during treatment.
Avoid exposure to excessive sunlight or artificial UV light, as it may cause photosensitivity.
Report any new or worsening symptoms, especially tendon pain, numbness, tingling, or unusual mood changes, to your doctor immediately.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Ciprofloxacin may cause dizziness or lightheadedness, and rarely, visual disturbances. If you experience these effects, avoid driving or operating machinery until you know how the medicine affects you.