Medicine Information

Clinacyn

Name: Clinacyn
Brand: Clinacyn
Rating: 4.5 (117 reviews)

Capsule150 mgLincosamide antibioticsATC: J01FF01

Generic Name

Clindamycin

Manufacturer

General Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
clinacyn 150 mg capsule	৳ 8.00	৳ 80.00

Description

Overview of the medicine

Clinacyn 150 mg Capsule contains Clindamycin, a lincosamide antibiotic, used to treat a wide range of bacterial infections including those of the skin, bone, joints, lungs, abdomen, and female reproductive organs.

Uses & Indications

Bacterial vaginosis

Acne vulgaris (severe cases)

Dental infections

Bone and joint infections

Respiratory tract infections

Skin and soft tissue infections

Intra-abdominal infections

Pelvic inflammatory disease

Dosage

Adults

150-300 mg every 6-8 hours, depending on the severity of infection. Maximum 450 mg every 6-8 hours for severe infections.

Elderly

No specific dose adjustment is usually required based on age alone; monitor renal/hepatic function.

Renal_impairment

No dosage adjustment needed for mild to moderate renal impairment. For severe impairment, consider reducing dose or extending dosing interval.

How to Take

Take orally with a full glass of water, with or without food, to prevent esophageal irritation. Do not lie down for at least 30 minutes after taking.

Mechanism of Action

Clindamycin binds to the 50S ribosomal subunit of susceptible bacteria, inhibiting bacterial protein synthesis. This action makes it primarily bacteriostatic, although it can be bactericidal at higher concentrations or against highly susceptible organisms.

Pharmacokinetics

Onset

Effect typically seen within a few hours of administration.

Excretion

Approximately 10-20% excreted in urine and 4% in faeces as active drug, with the remainder excreted as metabolites.

Half life

Approximately 2-3 hours in adults with normal renal and hepatic function. Can be prolonged in patients with severe renal or hepatic impairment.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract (about 90%) after oral administration. Peak plasma concentrations are reached within 45-60 minutes.

Metabolism

Primarily metabolized in the liver to active and inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to clindamycin, lincomycin, or any component of the formulation
History of antibiotic-associated colitis

Drug Interactions

Erythromycin

Concurrent use may result in antagonism as both drugs bind to the 50S ribosomal subunit.

Kaolin-pectin antidiarrheals

May reduce the absorption of oral clindamycin. Administer clindamycin at least 2 hours before these agents.

Neuromuscular blocking agents

Clindamycin may potentiate the action of these agents, leading to prolonged neuromuscular blockade.

Storage

Store below 30°C in a cool, dry place, away from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose may include gastrointestinal distress. Management is supportive and symptomatic. Hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the blood.

Pregnancy & Lactation

Pregnancy Category B. Use during pregnancy only if clearly needed. Clindamycin is excreted in breast milk; caution should be exercised when administered to a nursing woman.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules (1x10 strip)30 capsules (3x10 strips)

Shelf Life

Typically 24-36 months from the date of manufacture, specific to manufacturer and formulation.

Availability

Available in pharmacies, hospitals

Approval Status

Approved by regulatory authorities worldwide

Patent Status

Generic available, original patent expired

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established the efficacy and safety of clindamycin across various bacterial infections.

Lab Monitoring

Periodic liver and kidney function tests for prolonged therapy
Complete blood count (CBC) for prolonged therapy
Monitor for signs and symptoms of C. difficile-associated diarrhea

Doctor Notes

Counsel patients about the risk of C. difficile-associated diarrhea and to report persistent diarrhea immediately.
Advise patients to take with plenty of water to minimize esophageal irritation.
Consider alternative antibiotics if patient has a history of severe gastrointestinal issues with prior antibiotic use.

Patient Guidelines

Complete the full course of antibiotics, even if symptoms improve.
Take with a full glass of water to prevent throat irritation.
Report any severe diarrhea, abdominal pain, or bloody stools immediately.
Do not use for viral infections.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

Driving Precautions

Generally, clindamycin does not impair the ability to drive or operate machinery. However, if side effects like dizziness occur, avoid such activities.

Lifestyle Advice

Maintain good hygiene to prevent infections.
Consume probiotics (e.g., yogurt) to help maintain gut flora balance during antibiotic use, but not at the same time as the antibiotic.