Medicine Information

Clindax-B

Name: Clindax-B
Brand: Clindax-B
Rating: 4.5 (117 reviews)

Topical GelClindamycin 1% & Benzoyl Peroxide 5%Anti-acne preparationsATC: D10AF51

Generic Name

Clindamycin Phosphate 1% & Benzoyl Peroxide 5% Topical Gel

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
clindax b 1 5 topical gel	৳ 350.00	N/A

Description

Overview of the medicine

Clindax-B 1%/5% Topical Gel is a combination medication containing an antibiotic (Clindamycin) and a keratolytic agent (Benzoyl Peroxide) used for the topical treatment of acne vulgaris. It works by reducing acne-causing bacteria and unclogging pores.

Uses & Indications

Treatment of acne vulgaris (mild to moderate)

Reduction of inflammatory and non-inflammatory acne lesions

Dosage

Adults

Apply a thin layer to the affected areas once daily, or as directed by a physician, after washing and drying the skin.

Elderly

No specific dosage adjustment required; use as per adult dosage.

Renal_impairment

Not applicable for topical use due to minimal systemic absorption.

How to Take

For topical use only. Wash the affected skin gently, pat dry, and apply a thin layer of gel to the entire affected area (not just individual pimples) once daily in the evening, or as directed by the doctor. Avoid contact with eyes, lips, mouth, and mucous membranes.

Mechanism of Action

Clindamycin is an antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby suppressing the growth of Propionibacterium acnes (now Cutibacterium acnes). Benzoyl Peroxide has bactericidal activity against C. acnes and also acts as a keratolytic agent, reducing follicular hyperkeratosis and promoting the shedding of dead skin cells.

Pharmacokinetics

Onset

Visible improvement typically within 2-5 weeks of consistent use.

Excretion

Primarily through sebaceous glands and skin surface. Systemically absorbed components are excreted via urine and feces.

Half life

Not well-defined for topical application due to minimal systemic absorption; systemic clindamycin half-life is about 2.4 hours.

Absorption

Minimal systemic absorption after topical application. Clindamycin absorption is approximately 4-5%, while Benzoyl Peroxide is metabolized to benzoic acid, with minimal systemic absorption (about 5%).

Metabolism

Topically applied clindamycin is minimally metabolized. Benzoyl Peroxide is metabolized to benzoic acid in the skin.

Side Effects

Contraindications

Hypersensitivity to clindamycin, lincomycin, benzoyl peroxide, or any component of the formulation.
History of regional enteritis, ulcerative colitis, or antibiotic-associated colitis.

Drug Interactions

Dapsone topical

May cause temporary orange-yellow skin discoloration when used with benzoyl peroxide.

Erythromycin topical

Concurrent use should be avoided as it may antagonize the effects of clindamycin.

Sulfonamide-containing products

May lead to temporary skin discoloration with benzoyl peroxide.

Storage

Store below 30°C in a cool, dry place, protected from light. Do not freeze. Keep out of reach of children.

Overdose

Topical overdose is unlikely to produce systemic effects. Excessive application may result in redness, peeling, or discomfort. In case of accidental ingestion, seek medical advice immediately.

Pregnancy & Lactation

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is unknown if clindamycin or benzoyl peroxide are excreted in human milk after topical administration. Use with caution in breastfeeding mothers. Consult a doctor.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 gm tube15 gm tube

Shelf Life

Usually 24-36 months from the manufacturing date, check product label.

Availability

Pharmacies nationwide

Approval Status

Approved

Patent Status

Generic product available (Clindamycin and Benzoyl Peroxide are off-patent)

Clinical Trials

Numerous clinical trials have established the efficacy and safety of topical clindamycin and benzoyl peroxide combination in treating acne vulgaris, demonstrating superiority over monotherapy with either agent.

Lab Monitoring

No specific lab monitoring is required for topical application.

Doctor Notes

Emphasize patient education on proper application technique and sun protection.
Monitor for signs of excessive irritation or allergic reactions.
Counsel patients on the potential for antibiotic resistance with prolonged use of clindamycin and the importance of adhering to treatment duration.

Patient Guidelines

Use only as directed by your doctor.
Avoid contact with eyes, mouth, nose, and other mucous membranes.
If accidental contact occurs, rinse thoroughly with water.
Discontinue use and consult your doctor if irritation or sensitivity develops.
Apply sunscreen daily as this product may increase sun sensitivity.

Missed Dose Advice

If a dose is missed, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.