Medicine Information

Clinorel

Name: Clinorel
Brand: Clinorel
Rating: 4.5 (117 reviews)

Tablet100 mgAntibiotics (Lincosamides)ATC: J01FF01

Generic Name

clinorel-100-mg-tablet

Manufacturer

Specific manufacturer varies by region (e.g., Square Pharmaceuticals for Cleocin in Bangladesh)

Country

Global, widely manufactured

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
clinorel 100 mg tablet	৳ 5.00	৳ 50.00

Description

Overview of the medicine

Clinorel 100 mg Tablet is an antibiotic used to treat a wide variety of bacterial infections. It works by stopping the growth of bacteria.

Uses & Indications

Skin and soft tissue infections (e.g., cellulitis, abscesses)

Respiratory tract infections (e.g., pneumonia, bronchitis)

Dental infections (e.g., periodontal abscesses)

Bone and joint infections (e.g., osteomyelitis)

Gynecological infections (e.g., pelvic inflammatory disease)

Intra-abdominal infections

Dosage

Adults

150-450 mg every 6-8 hours, depending on the severity of infection.

Elderly

No specific dose adjustment is generally required, but monitor renal and hepatic function.

Renal_impairment

No dose adjustment needed for mild to moderate impairment; for severe impairment, consider lengthening dosing interval or reducing dose.

How to Take

Take orally with a full glass of water to prevent esophageal irritation. Can be taken with or without food.

Mechanism of Action

Clindamycin, the active ingredient, binds to the 50S ribosomal subunit of susceptible bacteria, thereby inhibiting protein synthesis. This action is primarily bacteriostatic.

Pharmacokinetics

Onset

Within 30-60 minutes after oral administration.

Excretion

Excreted in urine (about 10%) and feces (about 4%) as active drug and metabolites.

Half life

Approximately 2-3 hours in adults; prolonged in patients with severe renal or hepatic impairment.

Absorption

Rapidly and almost completely absorbed from the gastrointestinal tract (about 90%) after oral administration.

Metabolism

Primarily metabolized in the liver to active and inactive metabolites.

Side Effects

Contraindications

Hypersensitivity to clindamycin, lincomycin, or any component of the formulation
History of antibiotic-associated colitis (especially C. difficile-associated diarrhea)

Drug Interactions

Erythromycin

Antagonistic effects, concurrent use not recommended.

Oral typhoid vaccine

Antibiotics may decrease the therapeutic effect of the live oral typhoid vaccine.

Neuromuscular blockers

May enhance the action of neuromuscular blocking agents, leading to increased or prolonged muscle paralysis.

Storage

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Overdose

In case of overdose, symptomatic and supportive measures should be taken. Hemodialysis and peritoneal dialysis are not effective in removing clindamycin from the blood.

Pregnancy & Lactation

Pregnancy Category B. Use during pregnancy only if clearly needed. Clindamycin is excreted in breast milk; use with caution during lactation.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets30 tablets

Shelf Life

Typically 2-3 years from manufacturing date.

Availability

Available in pharmacies worldwide

Approval Status

Approved (Clindamycin is a well-established drug)

Patent Status

Off-patent (Generic available)

WHO Essential Medicine

Yes

Clinical Trials

Extensive clinical trials have established clindamycin's efficacy and safety for indicated bacterial infections since its introduction.

Lab Monitoring

Liver and kidney function tests for prolonged therapy
Complete blood count (CBC) for prolonged therapy

Doctor Notes

Emphasize the risk of C. difficile-associated diarrhea (CDAD) and instruct patients to report any persistent diarrhea.
Consider alternative antibiotics if patient has a history of gastrointestinal issues, especially colitis.
Monitor for signs of liver dysfunction during prolonged treatment.

Patient Guidelines

Complete the full course of treatment, even if symptoms improve.
Report severe or persistent diarrhea to your doctor immediately.
Take each dose with a full glass of water.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.