Medicine Information

Clobac

Name: Clobac
Brand: Clobac
Rating: 4.5 (117 reviews)

Pediatric Drop125 mg/5 mLAntibacterial (Penicillin class)ATC: J01CF02

Generic Name

Cloxacillin

Manufacturer

Acme Laboratories Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
clobac 125 mg pediatric drop	৳ 125.47	N/A

Description

Overview of the medicine

Cloxacillin is a penicillin antibiotic used to treat bacterial infections, particularly those caused by penicillinase-producing staphylococci. It is effective against various skin, soft tissue, respiratory, and bone infections.

Uses & Indications

Skin and soft tissue infections (e.g., cellulitis, carbuncles, furunculosis, impetigo)

Respiratory tract infections (e.g., pneumonia, bronchitis, tonsillitis)

Bone and joint infections (e.g., osteomyelitis)

Endocarditis

Septicemia caused by susceptible organisms

Dosage

Adults

Not applicable for pediatric drops. Adults typically use capsules or tablets.

Elderly

Not applicable for pediatric drops. Elderly patients using other forms may require renal dosage adjustment.

Renal_impairment

In severe renal impairment (creatinine clearance < 10 mL/min), dosage reduction or extended dosing interval may be necessary. Consult a physician.

Pediatric_general

For children under 2 years: 62.5 mg (2.5 mL) every 6 hours. For children 2-10 years: 125 mg (5 mL) every 6 hours. Doses may be increased in severe infections, as directed by a physician.

How to Take

Administer orally. Shake the bottle well before each use. Measure the dose accurately using the provided dropper or measuring spoon. It is best taken on an empty stomach (1 hour before or 2 hours after meals) for optimal absorption, but can be taken with food to minimize gastrointestinal upset.

Mechanism of Action

Cloxacillin is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death.

Pharmacokinetics

Onset

Rapid

Excretion

Primarily via renal excretion (urine) and bile.

Half life

0.5-1.5 hours in adults, may be prolonged in neonates.

Absorption

Well absorbed orally, but food reduces absorption. Peak plasma concentrations are achieved within 1-2 hours.

Metabolism

Partially metabolized in the liver to inactive metabolites.

Side Effects

Contraindications

Known hypersensitivity to penicillin antibiotics or any component of the formulation.
History of severe allergic reaction (e.g., anaphylaxis, Stevens-Johnson syndrome) to any beta-lactam antibiotic.

Drug Interactions

Warfarin

May increase the anticoagulant effect of warfarin, requiring monitoring of INR.

Probenecid

Increases and prolongs plasma concentrations of cloxacillin by inhibiting renal tubular secretion.

Methotrexate

Cloxacillin may decrease the renal excretion of methotrexate, leading to increased methotrexate toxicity.

Tetracyclines/Chloramphenicol

These bacteriostatic antibiotics may antagonize the bactericidal effect of penicillin.

Storage

Store the dry powder below 30°C, protected from light and moisture. Once reconstituted, store the suspension in a refrigerator (2-8°C) and discard after the recommended period (usually 7-14 days). Do not freeze.

Overdose

Overdose is generally associated with gastrointestinal symptoms (nausea, vomiting, diarrhea) and electrolyte imbalance. In very high doses, CNS excitation and convulsions may occur. Treatment is symptomatic and supportive; no specific antidote exists. Hemodialysis may be beneficial in severe cases.

Pregnancy & Lactation

Pregnancy Category B. Animal reproduction studies have shown no risk, but human data are limited. Use only if clearly needed. Cloxacillin is excreted in small amounts in breast milk; use with caution during lactation, monitoring the infant for adverse effects like diarrhea or candidiasis.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

15 mL bottle (after reconstitution)30 mL bottle (after reconstitution)

Shelf Life

Unreconstituted powder: 24-36 months. Reconstituted suspension: 7-14 days when refrigerated (2-8°C).

Availability

Pharmacies, Hospitals

Approval Status

Approved

Patent Status

Generic

WHO Essential Medicine

Yes

Clinical Trials

Cloxacillin has been extensively studied since its introduction in 1965, with numerous clinical trials establishing its efficacy and safety profile in treating staphylococcal infections.

Lab Monitoring

Liver function tests (LFTs) for prolonged therapy or in patients with hepatic impairment.
Renal function tests (e.g., creatinine, BUN) in patients with pre-existing renal impairment or on high doses.
Complete blood count (CBC) during prolonged therapy.

Doctor Notes

Emphasize the importance of completing the full prescribed course to prevent antibiotic resistance and ensure complete eradication of the infection.
Educate parents on proper reconstitution, accurate measurement, and storage of the pediatric drop.
Monitor for signs of allergic reactions, especially in patients with a history of penicillin allergy.

Patient Guidelines

Complete the entire course of medication as prescribed by the doctor, even if symptoms improve, to prevent recurrence and antibiotic resistance.
Shake the bottle well before administering each dose.
Use the provided measuring device to ensure accurate dosing for your child.
Store the reconstituted drop in the refrigerator and discard any unused portion after the recommended period (usually 7-14 days).

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your child's next dose. In that case, skip the missed dose and continue with the regular dosing schedule. Do not double the dose.

Driving Precautions

Cloxacillin is generally not known to impair the ability to drive or operate machinery. However, if side effects like dizziness occur, caution should be advised.