Medicine Information

Cloram

Name: Cloram
Brand: Cloram
Rating: 4.5 (117 reviews)

Eye Ointment1% w/wOphthalmic AntibioticsATC: S01AA01

Generic Name

Chloramphenicol

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cloram 1 eye ointment	৳ 13.00	N/A

Description

Overview of the medicine

Cloram 1% Eye Ointment contains Chloramphenicol, an antibiotic used to treat bacterial infections of the eye including bacterial conjunctivitis, keratitis, and blepharitis.

Uses & Indications

Treatment of superficial ocular infections involving the conjunctiva and/or cornea caused by chloramphenicol-susceptible bacteria.

Bacterial conjunctivitis

Bacterial keratitis

Blepharitis

Dosage

Adults

Apply a small amount (approximately 1 cm ribbon) into the conjunctival sac 3-4 times daily, or more frequently if required, for 5-7 days or as directed by a physician.

Elderly

No special dosage adjustment is generally required.

Renal_impairment

No special dosage adjustment is generally required for topical ophthalmic use.

How to Take

Wash hands thoroughly before and after application. Gently pull down the lower eyelid to form a pocket. Apply a thin strip of ointment into the pocket. Close the eye gently for a few seconds. Do not touch the tip of the tube to the eye or any other surface.

Mechanism of Action

Chloramphenicol is a broad-spectrum antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing peptide bond formation and bacterial growth.

Pharmacokinetics

Onset

Within hours (local effect)

Excretion

Excreted mainly in the urine as inactive metabolites if systemically absorbed.

Half life

Not well-defined for topical ophthalmic use; systemic half-life is 1.6-3.3 hours.

Absorption

Following topical ophthalmic administration, chloramphenicol penetrates the cornea and aqueous humor. Systemic absorption is minimal but can occur.

Metabolism

Primarily metabolized in the liver (glucuronidation) if systemically absorbed.

Side Effects

Contraindications

Hypersensitivity to chloramphenicol or any component of the formulation.
History of bone marrow depression or blood dyscrasias associated with chloramphenicol use.

Drug Interactions

No significant drug interactions have been reported for topical ophthalmic chloramphenicol.

However, systemic absorption is possible, albeit minimal, so caution should be exercised with drugs that may affect bone marrow or are metabolized by hepatic enzymes.

Storage

Store below 25°C. Protect from light. Do not freeze. Keep out of reach of children.

Overdose

Accidental ingestion of the eye ointment is unlikely to cause systemic toxicity due to the small amount of drug. Topical overdose may lead to increased local side effects such as stinging or irritation. Management should be supportive and symptomatic.

Pregnancy & Lactation

Chloramphenicol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is excreted in breast milk; therefore, caution should be exercised when administered to a nursing mother. Consult a physician.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

3.5g tube5g tube

Shelf Life

Typically 2-3 years for unopened product. Discard 28 days after opening.

Availability

Available in pharmacies nationwide.

Approval Status

Approved

Patent Status

Off-patent

WHO Essential Medicine

Yes

Clinical Trials

As Chloramphenicol is an established antibiotic, new large-scale clinical trials for its ophthalmic formulation are uncommon. Efficacy and safety are well-documented from historical data.

Lab Monitoring

Routine laboratory monitoring is generally not required for topical ophthalmic use.

Doctor Notes

Emphasize the importance of completing the full course of treatment to prevent antibiotic resistance and recurrence.
Advise patients on proper administration technique to minimize contamination.
Educate on symptoms of severe adverse reactions, especially signs of bone marrow suppression, and when to seek immediate medical attention.

Patient Guidelines

Complete the full course of treatment, even if symptoms improve.
Do not wear contact lenses during treatment for eye infection.
Do not share your eye ointment with others.
Wash your hands before and after applying the ointment.

Missed Dose Advice

If a dose is missed, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.

Driving Precautions

Cloram 1% Eye Ointment may cause temporary blurred vision or other visual disturbances. Patients should be advised not to drive or operate machinery until their vision is clear.