Medicine Information

Codvit

Name: Codvit
Brand: Codvit
Rating: 4.5 (117 reviews)

Capsule600 IUVitamin D & Analogues, VitaminsATC: A11CC05

Generic Name

Cholecalciferol (Vitamin D3)

Manufacturer

Popular Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
codvit 600 iu capsule	৳ 2.00	৳ 20.00

Description

Overview of the medicine

Codvit 600 IU Capsule contains Cholecalciferol (Vitamin D3), essential for calcium and phosphate absorption, bone health, and immune system support. It is used to prevent and treat Vitamin D deficiency.

Uses & Indications

Prevention and treatment of Vitamin D deficiency

Osteoporosis (as an adjunct to specific therapy)

Rickets and Osteomalacia

Hypoparathyroidism

Dosage

Adults

For Vitamin D deficiency prevention, typically 600-800 IU daily. For treatment, higher doses may be prescribed by a physician based on serum 25(OH)D levels. Usually, 1 capsule once daily.

Elderly

Similar to adults, sometimes higher doses (e.g., 800-1000 IU daily) due to reduced skin synthesis and impaired absorption.

Renal_impairment

Use with caution and monitor serum calcium and phosphate levels. Doses may need adjustment based on severity and concomitant therapies.

How to Take

Take orally, preferably with the largest meal of the day to enhance absorption, as it is a fat-soluble vitamin. Do not crush or chew the capsule; swallow it whole with water.

Mechanism of Action

Cholecalciferol is converted in the liver to 25-hydroxycholecalciferol (calcifediol) and then in the kidneys to 1,25-dihydroxycholecalciferol (calcitriol), the active form of Vitamin D. Calcitriol promotes calcium and phosphate absorption from the intestine, enhances bone mineralization, and helps maintain calcium homeostasis.

Pharmacokinetics

Onset

Therapeutic effects may take several days to weeks to manifest, as conversion to active metabolites and subsequent physiological changes occur gradually.

Excretion

Mainly excreted in bile and feces, with a small amount excreted renally.

Half life

Cholecalciferol (parent compound) has a plasma half-life of approximately 15-24 hours. The main circulating metabolite, 25-hydroxyvitamin D [25(OH)D], has a half-life of 2-3 weeks.

Absorption

Absorbed from the small intestine, primarily in the jejunum and ileum. Absorption is enhanced by the presence of bile salts and dietary fat.

Metabolism

Initially hydroxylated in the liver by CYP2R1 and CYP27A1 to 25-hydroxycholecalciferol [25(OH)D]. This is then further hydroxylated in the kidneys by CYP27B1 to the active form, 1,25-dihydroxycholecalciferol [1,25(OH)2D] (calcitriol).

Side Effects

Contraindications

Hypercalcemia (high calcium levels in blood)
Hypervitaminosis D (excessive Vitamin D levels)
Severe renal impairment (without proper monitoring)
Known hypersensitivity to Vitamin D or any component of the formulation

Drug Interactions

Corticosteroids

Can reduce the effects of Vitamin D.

Thiazide Diuretics

May increase the risk of hypercalcemia.

Digitalis Glycosides

Hypercalcemia caused by Vitamin D can potentiate the effects of digitalis, leading to cardiac arrhythmias.

Cholestyramine, Colestipol, Orlistat

May impair the absorption of Vitamin D.

Anticonvulsants (e.g., Phenytoin, Carbamazepine)

May increase the metabolism of Vitamin D, reducing its effectiveness.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Symptoms of Vitamin D overdose (hypervitaminosis D) include hypercalcemia, which can lead to nausea, vomiting, loss of appetite, thirst, polyuria (frequent urination), constipation, muscle weakness, fatigue, headache, and in severe cases, kidney damage, cardiac arrhythmias, and coma. Management involves discontinuing Vitamin D, reducing calcium intake, and hydration. Medical supervision is essential.

Pregnancy & Lactation

Recommended daily allowances of Vitamin D are safe during pregnancy and lactation. Higher doses should only be used if prescribed by a doctor, as excessive doses can be harmful to the fetus or infant.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 capsules30 capsules60 capsules

Shelf Life

Typically 2-3 years from the date of manufacture.

Availability

Pharmacies, supermarkets, online stores

Approval Status

Approved (Generally available over-the-counter or by prescription)

Patent Status

Off-patent

Clinical Trials

Extensive clinical trials and research have established the efficacy and safety of Cholecalciferol (Vitamin D3) for bone health, calcium homeostasis, and immune function across various populations.

Lab Monitoring

Serum 25(OH)D levels (to assess Vitamin D status)
Serum calcium and phosphate levels (to monitor for hypercalcemia)

Doctor Notes

Emphasize the importance of adequate calcium intake alongside Vitamin D.
Advise patients on lifestyle modifications including diet and sun exposure.
Monitor serum 25(OH)D, calcium, and phosphate levels, especially in high-risk patients or those on higher doses.

Patient Guidelines

Take the capsule as directed by your doctor or pharmacist.
Do not exceed the recommended dose without consulting a healthcare professional.
Inform your doctor about all other medications and supplements you are taking.
Ensure adequate dietary calcium intake alongside Vitamin D supplementation.

Missed Dose Advice

If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.

Driving Precautions

Codvit 600 IU Capsule is not known to affect the ability to drive or operate machinery.

Lifestyle Advice

Maintain a balanced diet rich in calcium and Vitamin D sources.
Get regular, moderate sun exposure (if appropriate) for natural Vitamin D synthesis.
Engage in weight-bearing exercises for bone health.