Medicine Information

Cosarin

Name: Cosarin
Brand: Cosarin
Rating: 4.5 (117 reviews)

Tablet750 mgDrugs for osteoarthritisATC: M01AX05

Generic Name

Glucosamine Sulphate 750 mg

Manufacturer

Square Pharmaceuticals Ltd.

Country

Bangladesh

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Price Details

Current market pricing information

Variant	Unit Price	Strip Price
cosarin 750 mg tablet	৳ 14.00	৳ 84.00

Description

Overview of the medicine

Cosarin 750 mg Tablet contains Glucosamine Sulphate, which is primarily used to treat the symptoms of osteoarthritis. It helps in the formation and repair of cartilage, thereby improving joint function and reducing pain.

Uses & Indications

Osteoarthritis of the knee

Osteoarthritis of the hip

Osteoarthritis of the spine (spondylosis)

Other joint pains associated with degenerative joint disease

Dosage

Adults

One 750 mg tablet twice daily, or as directed by the physician. Some regimens suggest 1500 mg once daily.

Elderly

No specific dose adjustment is required for the elderly. Dosage as for adults.

Renal_impairment

No specific dose adjustment is required for mild to moderate renal impairment. Use with caution in severe renal impairment, consult physician.

How to Take

Cosarin tablets should be swallowed whole with water. It can be taken with or without food, but taking it with food may help to reduce gastrointestinal discomfort.

Mechanism of Action

Glucosamine is an amino sugar that plays a crucial role in cartilage formation. It stimulates the synthesis of proteoglycans and collagen, inhibiting the degradation of cartilage by enzymes and free radicals. This action helps to rebuild damaged cartilage and improve joint lubrication.

Pharmacokinetics

Onset

Symptomatic relief usually occurs after 2-3 weeks of treatment; full effect may take 4-8 weeks.

Excretion

Mainly excreted via urine (approximately 10%), with some excretion via feces and exhaled CO2.

Half life

Approximately 15 hours.

Absorption

Well absorbed orally, with bioavailability ranging from 25-30%.

Metabolism

Primarily metabolized in the liver, with some metabolism in the intestinal wall. It is incorporated into glycoproteins and proteoglycans.

Side Effects

Contraindications

Hypersensitivity to Glucosamine or any component of the tablet
Allergy to shellfish (if Glucosamine is sourced from shellfish)
Pregnancy and lactation (due to insufficient data)
Severe liver or kidney disease (use with caution)

Drug Interactions

Warfarin

Glucosamine may potentiate the effects of Warfarin, increasing the risk of bleeding. Close monitoring of INR is recommended.

Antidiabetic medications

Glucosamine may affect glucose metabolism. Diabetics should monitor blood glucose levels closely.

Tetracycline antibiotics

May increase the absorption of tetracyclines.

Storage

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.

Overdose

Glucosamine Sulphate is generally well-tolerated, even at higher doses. In case of an overdose, symptomatic and supportive measures should be taken. Gastric lavage may be considered if a large amount is ingested.

Pregnancy & Lactation

Cosarin is not recommended during pregnancy or lactation due to insufficient data on safety. Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

Box containing 3x10 tablets in blister stripsBox containing 5x10 tablets in blister strips

Shelf Life

3 years from manufacturing date

Availability

Pharmacies nationwide

Approval Status

Approved by DGDA

Patent Status

Generic

Clinical Trials

Numerous clinical trials have investigated the efficacy and safety of Glucosamine Sulphate in osteoarthritis, showing varying degrees of benefit, particularly in mild to moderate cases. Some studies suggest it may have a disease-modifying effect.

Lab Monitoring

Blood glucose levels (for diabetic patients)
INR (International Normalized Ratio) for patients on Warfarin

Doctor Notes

Advise patients on the delayed onset of action and the importance of continuous therapy for optimal results.
Inquire about shellfish allergies before prescribing, as some Glucosamine products are derived from shellfish.
Monitor INR in patients co-administered with Warfarin and blood glucose in diabetic patients.

Patient Guidelines

Take the medicine as prescribed by your doctor, do not exceed the recommended dose.
It may take several weeks to notice the full benefits of this medicine.
Inform your doctor if you experience any unusual side effects or if your symptoms do not improve.

Missed Dose Advice

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.