Medicine Information

Criptine

Name: Criptine
Brand: Criptine
Rating: 4.5 (117 reviews)

Tablet25 mgDopamine Agonists, Prolactin InhibitorsATC: G02CB01

Generic Name

Bromocriptine-25-mg-tablet

Manufacturer

XYZ Pharma (Example Manufacturer)

Country

Bangladesh

Loading images...

Price Details

Current market pricing information

Variant	Unit Price	Strip Price
criptine 25 mg tablet	৳ 12.00	৳ 360.00

Description

Overview of the medicine

Bromocriptine is a dopamine agonist used in the treatment of various conditions including Parkinson's disease, hyperprolactinemia (e.g., amenorrhea, galactorrhea, infertility), acromegaly, and type 2 diabetes mellitus.

Uses & Indications

Parkinson's disease (adjunctive or monotherapy)

Hyperprolactinemia (amenorrhea, galactorrhea, infertility)

Acromegaly

Prolactin-secreting adenomas

Type 2 diabetes mellitus (Cycloset brand only)

Dosage

Adults

Dosage varies widely by indication. For hyperprolactinemia, initial dose typically 1.25 mg at bedtime, increasing gradually to 2.5-15 mg/day. For Parkinson's, initial dose 1.25 mg once or twice daily, titrated up to 20-100 mg/day depending on response. Always start low and titrate slowly.

Elderly

Start with lower doses and titrate gradually due to increased sensitivity to side effects.

Renal_impairment

No specific dosage adjustment for mild to moderate renal impairment, but caution is advised. Not studied in severe renal impairment.

How to Take

Take orally, usually with food to minimize gastrointestinal upset. Swallow tablets whole with water.

Mechanism of Action

Stimulates postsynaptic dopamine D2 receptors, inhibits prolactin secretion from the pituitary gland, and reduces growth hormone secretion in acromegaly.

Pharmacokinetics

Onset

Prolactin-lowering effects within 1-2 hours; peak plasma concentration in 1-3 hours.

Excretion

Mainly excreted via bile and feces (85%), with a small amount (5%) excreted renally.

Half life

Biphasic elimination with a terminal half-life of approximately 4.5-5 hours.

Absorption

Well absorbed orally, but undergoes extensive first-pass metabolism; bioavailability is about 28%.

Metabolism

Extensively metabolized in the liver, primarily by cytochrome P450 3A4 (CYP3A4).

Side Effects

Contraindications

Uncontrolled hypertension
Pre-eclampsia, eclampsia, or postpartum hypertension
Hypersensitivity to bromocriptine or other ergot alkaloids
Ischemic heart disease or severe peripheral vascular disease (for some indications)

Drug Interactions

Ergot alkaloids

Increased risk of adverse cardiovascular events.

Sympathomimetics

May increase the risk of hypertension.

Dopamine antagonists (e.g., antipsychotics)

May reduce the effectiveness of bromocriptine.

CYP3A4 inhibitors (e.g., erythromycin, ketoconazole)

Can increase bromocriptine plasma levels and adverse effects.

Storage

Store below 30°C (86°F), protected from light and moisture. Keep out of reach of children.

Overdose

Symptoms of overdose include nausea, vomiting, dizziness, orthostatic hypotension, hallucinations, and confusion. Management is supportive, focusing on symptomatic treatment and maintaining cardiovascular stability.

Pregnancy & Lactation

Contraindicated during pregnancy for the inhibition of physiological lactation. For other indications, use only if clearly needed and benefits outweigh risks. Bromocriptine inhibits lactation and should be avoided in nursing mothers.

Frequently Asked Questions

Common questions about this medicine

Pack Sizes

10 tablets per blister30 tablets per box

Shelf Life

2-3 years from manufacturing date.

Availability

Pharmacies, Hospitals

Approval Status

Approved (e.g., FDA/DGDA)

Patent Status

Generic available

WHO Essential Medicine

Yes

Clinical Trials

Extensively studied since its introduction for various endocrine and neurological disorders. Ongoing research explores its role in other conditions like obesity and addiction.

Lab Monitoring

Prolactin levels (for hyperprolactinemia)
Growth hormone/IGF-1 levels (for acromegaly)
Blood pressure (especially postpartum and with dose titration)
Renal and hepatic function tests (periodically)

Doctor Notes

Emphasize slow dose titration to minimize dopaminergic side effects.
Monitor blood pressure regularly, particularly in postpartum patients.
Counsel patients on orthostatic hypotension and potential for somnolence.
Consider drug interactions, especially with CYP3A4 inhibitors and dopamine antagonists.

Patient Guidelines

Take with food to reduce nausea and stomach upset.
Stand up slowly to avoid dizziness from orthostatic hypotension.
Report any unusual side effects, especially hallucinations, confusion, or severe headache.
Avoid alcohol while taking this medication.

Missed Dose Advice

If a dose is missed, take it as soon as you remember, unless it is almost time for your next scheduled dose. Do not double doses.

Driving Precautions

Bromocriptine may cause dizziness, somnolence, or sudden onset of sleep. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that bromocriptine therapy does not affect them adversely.